DOI QR코드

DOI QR Code

The NQO1 rs1800566 Polymorphism and Risk of Bladder Cancer: Evidence from 6,169 Subjects

  • Guo, Zhan-Jing (Shijiazhuang Municipal Center for Disease Control and Prevention) ;
  • Feng, Chang-Long (Bethune Military Medical College of PLA)
  • Published : 2012.12.31

Abstract

Objective: The NAD(P)H:quinone oxidoreductase 1 (NQO1) rs1800566 polymorphism, leading to proline-toserine amino-acid and enzyme activity changes, has been implicated in bladder cancer risk, but individually published studies showed inconsistent results. We therefore here conducted a meta-analysis to summarize the possible association. Methods: A systematic literature search up to August 27, 2012 was carried out in PubMed, EMBASE and Wanfang databases, and the references of retrieved articles were screened. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were analyzed for homozygote contrast (TT vs. CC), additive model (T vs. C), dominant model (TT+CT vs. CC), and recessive model (TT vs. CC+CT) to assess the association using fixed- or random-effect models. Results: We identified 12 case-control studies including 3,041 cases and 3,128 controls for the present meta-analysis. Significant association between NQO1 rs1800566 genetic polymorphism and risk of bladder cancer was observed in the additive model (OR = 1.15, 95% CI = 1.01-1.30, p = 0.030). Moreover, in the subgroup analysis stratified by ethnicity, significant associations were observed in Asians (OR = 1.26, 95% CI = 1.08-1.47, p = 0.003 for T vs. C; OR = 1.68, 95% CI = 1.21-2.32, p = 0.002 for TT vs. CC; OR = 1.50, 95% CI = 1.13-1.98, p = 0.005 for TT vs. CT+CC) but not in Caucasians. Conclusions: The results suggest that NQO1 rs1800566 genetic polymorphism may contribute to bladder cancer development, especially in Asians.

Keywords

NQO1;polymorphism;bladder cancer;meta-analysis

References

  1. Zhang Y, Wang ZT, Zhong J (2012). Meta-analysis demonstrates that the NAD(P)H: quinone oxidoreductase 1 (NQO1) gene 609 C>T polymorphism is associated with increased gastric cancer risk in Asians. Genet Mol Res, 11, 2328-37. https://doi.org/10.4238/2012.August.13.6
  2. Ross D, Siegel D (2004). NAD(P)H:quinone oxidoreductase 1 (NQO1, DT-diaphorase), functions and pharmacogenetics. Methods Enzymol, 382, 115-44. https://doi.org/10.1016/S0076-6879(04)82008-1
  3. Ryk C, Kumar R, Sanyal S, et al (2006). Influence of polymorphism in DNA repair and defence genes on p53 mutations in bladder tumours. Cancer Lett, 241, 142-9. https://doi.org/10.1016/j.canlet.2005.10.025
  4. Sanyal S, Festa F, Sakano S, et al (2004). Polymorphisms in DNA repair and metabolic genes in bladder cancer. Carcinogenesis, 25, 729-34.
  5. Sanyal S, Ryk C, De Verdier PJ, et al (2007). Polymorphisms in NQO1 and the clinical course of urinary bladder neoplasms. Scand J Urol Nephrol, 41, 182-90. https://doi.org/10.1080/00365590600991946
  6. Schulz WA, Krummeck A, Rosinger I, et al (1997). Increased frequency of a null-allele for NAD(P)H: quinone oxidoreductase in patients with urological malignancies. Pharmacogenetics, 7, 235-9. https://doi.org/10.1097/00008571-199706000-00008
  7. Siegel D, McGuinness SM, Winski SL, Ross D (1999). Genotypephenotype relationships in studies of a polymorphism in NAD(P)H:quinone oxidoreductase 1. Pharmacogenetics, 9, 113-21. https://doi.org/10.1097/00008571-199902000-00015
  8. Siegel D, Gustafson DL, Dehn DL, et al (2004). NAD(P) H:quinone oxidoreductase 1: role as a superoxide scavenger. Mol Pharmacol, 65, 1238-47. https://doi.org/10.1124/mol.65.5.1238
  9. Terry PD, Umbach DM, Taylor JA (2005). No association between SOD2 or NQO1 genotypes and risk of bladder cancer. Cancer Epidemiol Biomarkers Prev, 14, 753-4. https://doi.org/10.1158/1055-9965.EPI-04-0574
  10. Thakkinstian A, McKay GJ, McEvoy M, et al (2011). Systematic review and meta-analysis of the association between complement component 3 and age-related macular degeneration: a HuGE review and meta-analysis. Am J Epidemiol, 173, 1365-79. https://doi.org/10.1093/aje/kwr025
  11. Tsvetkov P, Reuven N, Shaul Y (2010). Ubiquitin-independent p53 proteasomal degradation. Cell Death Differ, 17, 103-8. https://doi.org/10.1038/cdd.2009.67
  12. Vineis P, Veglia F, Garte S, et al (2007). Genetic susceptibility according to three metabolic pathways in cancers of the lung and bladder and in myeloid leukemias in nonsmokers. Ann Oncol, 18, 1230-42. https://doi.org/10.1093/annonc/mdm109
  13. Wacholder S, Chanock S, Garcia-Closas M, et al (2004). Assessing the probability that a positive report is false: an approach for molecular epidemiology studies. J Natl Cancer Inst, 96, 434-42. https://doi.org/10.1093/jnci/djh075
  14. Wang YH, Lee YH, Tseng PT, et al (2008). Human NAD(P) H:quinone oxidoreductase 1 (NQO1) and sulfotransferase 1A1 (SULT1A1) polymorphisms and urothelial cancer risk in Taiwan. J Cancer Res Clin Oncol, 134, 203-9.
  15. Wen H, Ding Q, Fang ZJ, et al (2009). Population study of genetic polymorphisms and superficial bladder cancer risk in Han- Chinese smokers in Shanghai. Int Urol Nephrol, 41, 855-64. https://doi.org/10.1007/s11255-009-9560-y
  16. Workman P (1994). Enzyme-directed bioreductive drug development revisited: a commentary on recent progress and future prospects with emphasis on quinone anticancer agents and quinone metabolizing enzymes, particularly DTdiaphorase. Oncol Res, 6, 461-75.
  17. Yu H, Liu H, Wang LE, Wei Q (2012). A functional NQO1 609C>T polymorphism and risk of gastrointestinal cancers: a metaanalysis. PLoS One, 7, e30566. https://doi.org/10.1371/journal.pone.0030566
  18. Hung RJ, Boffetta P, Brennan P, et al (2004). Genetic polymorphisms of MPO, COMT, MnSOD, NQO1, interactions with environmental exposures and bladder cancer risk. Carcinogenesis, 25, 973-8. https://doi.org/10.1093/carcin/bgh080
  19. Iskander K, Gaikwad A, Paquet M, et al (2005). Lower induction of p53 and decreased apoptosis in NQO1-null mice lead to increased sensitivity to chemical-induced skin carcinogenesis. Cancer Res, 65, 2054-8. https://doi.org/10.1158/0008-5472.CAN-04-3157
  20. Jamieson D, Wilson K, Pridgeon S, et al (2007). NAD(P) H:quinone oxidoreductase 1 and nrh:quinone oxidoreductase 2 activity and expression in bladder and ovarian cancer and lower NRH:quinone oxidoreductase 2 activity associated with an NQO2 exon 3 single-nucleotide polymorphism. Clin Cancer Res, 13, 1584-90. https://doi.org/10.1158/1078-0432.CCR-06-1416
  21. Jemal A, Bray F, Center MM, et al (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90. https://doi.org/10.3322/caac.20107
  22. Lichtenstein P, Holm NV, Verkasalo PK, et al (2000). Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland. N Engl J Med, 343, 78-85. https://doi.org/10.1056/NEJM200007133430201
  23. Long DJ, 2nd, Waikel RL, Wang XJ, et al (2000). NAD(P) H:quinone oxidoreductase 1 deficiency increases susceptibility to benzo(a)pyrene-induced mouse skin carcinogenesis. Cancer Res, 60, 5913-5.
  24. Mantel N and Haenszel W (1959). Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst, 22, 719-48.
  25. Martone T, Vineis P, Malaveille C, Terracini B (2000). Impact of polymorphisms in xeno(endo)biotic metabolism on pattern and frequency of p53 mutations in bladder cancer. Mutat Res, 462, 303-9. https://doi.org/10.1016/S1383-5742(00)00013-2
  26. Moore LE, Wiencke JK, Bates MN, et al (2004). Investigation of genetic polymorphisms and smoking in a bladder cancer case-control study in Argentina. Cancer Lett, 211, 199-207. https://doi.org/10.1016/j.canlet.2004.04.011
  27. Murta-Nascimento C, Schmitz-Drager BJ, Zeegers MP, et al (2007). Epidemiology of urinary bladder cancer: from tumor development to patient's death. World J Urol, 25, 285-95. https://doi.org/10.1007/s00345-007-0168-5
  28. Nebert DW, Roe AL, Vandale SE, et al (2002). NAD(P)H:quinone oxidoreductase (NQO1) polymorphism, exposure to benzene, and predisposition to disease: a HuGE review. Genet Med, 4, 62-70. https://doi.org/10.1097/00125817-200203000-00003
  29. O'Brien PJ (1991). Molecular mechanisms of quinone cytotoxicity. Chem Biol Interact, 80, 1-41. https://doi.org/10.1016/0009-2797(91)90029-7
  30. Pandith AA, Khan NP, Shah ZA, et al (2011). Association of bladder cancer risk with an NAD(P)H:quinone oxidoreductase polymorphism in an ethnic Kashmiri population. Biochem Genet, 49, 417-26. https://doi.org/10.1007/s10528-011-9418-8
  31. Paonessa JD, Munday CM, Mhawech-Fauceglia P, et al (2009). 5,6-Dihydrocyclopenta[c][1,2]-dithiole-3(4H)-thione is a promising cancer chemopreventive agent in the urinary bladder. Chem Biol Interact, 180, 119-26. https://doi.org/10.1016/j.cbi.2008.12.001
  32. Park SJ, Zhao H, Spitz MR, et al (2003). An association between NQO1 genetic polymorphism and risk of bladder cancer. Mutat Res, 536, 131-7. https://doi.org/10.1016/S1383-5718(03)00041-X
  33. Ploeg M, Aben KK and Kiemeney LA (2009). The present and future burden of urinary bladder cancer in the world. World J Urol, 27, 289-93. https://doi.org/10.1007/s00345-009-0383-3
  34. Anwar A, Dehn D, Siegel D, et al (2003). Interaction of human NAD(P)H:quinone oxidoreductase 1 (NQO1) with the tumor suppressor protein p53 in cells and cell-free systems. J Biol Chem, 278, 10368-73. https://doi.org/10.1074/jbc.M211981200
  35. Asher G, Lotem J, Kama R, et al (2002). NQO1 stabilizes p53 through a distinct pathway. Proc Natl Acad Sci USA, 99, 3099-104. https://doi.org/10.1073/pnas.052706799
  36. Basu S, Brown JE, Flannigan GM, et al (2004). NAD(P) H:Quinone oxidoreductase-1 C609T polymorphism analysis in human superficial bladder cancers: relationship of genotype status to NQO1 phenotype and clinical response to Mitomycin C. Int J Oncol, 25, 921-7.
  37. Begg CB and Mazumdar M (1994). Operating characteristics of a rank correlation test for publication bias. Biometrics, 50, 1088-101. https://doi.org/10.2307/2533446
  38. Broberg K, Bjork J, Paulsson K, et al (2005). Constitutional short telomeres are strong genetic susceptibility markers for bladder cancer. Carcinogenesis, 26, 1263-71.
  39. Burger M, Catto JW, Dalbagni G, et al (2012). Epidemiology and risk factors of urothelial bladder cancer. Eur Urol, 63, 234-41.
  40. Chao C, Zhang ZF, Berthiller J, et al (2006). NAD(P)H:quinone oxidoreductase 1 (NQO1) Pro187Ser polymorphism and the risk of lung, bladder, and colorectal cancers: a meta-analysis. Cancer Epidemiol Biomarkers Prev, 15, 979-87. https://doi.org/10.1158/1055-9965.EPI-05-0899
  41. Choi JY, Lee KM, Cho SH, et al (2003). CYP2E1 and NQO1 genotypes, smoking and bladder cancer. Pharmacogenetics, 13, 349-55. https://doi.org/10.1097/00008571-200306000-00006
  42. Danson S, Ward TH, Butler J and Ranson M (2004). DTdiaphorase: a target for new anticancer drugs. Cancer Treat Rev, 30, 437-49. https://doi.org/10.1016/j.ctrv.2004.01.002
  43. DerSimonian R and Laird N (1986). Meta-analysis in clinical trials. Control Clin Trials, 7, 177-88. https://doi.org/10.1016/0197-2456(86)90046-2
  44. Dhaini H, Bassma H, Kobeissi L, Jabbour M (2012). CYP2E1 and NQO1 genotypes in bladder cancer - A lebanese case-control study. Eur J Cancer, 48, S277.
  45. Ding R, Lin S and Chen D (2012). Association of NQO1 rs1800566 polymorphism and the risk of colorectal cancer: a meta-analysis. Int J Colorectal Dis, 27, 885-92. https://doi.org/10.1007/s00384-011-1396-0
  46. Egger M, Davey Smith G, Schneider M, Minder C (1997). Bias in meta-analysis detected by a simple, graphical test. BMJ, 315, 629-34. https://doi.org/10.1136/bmj.315.7109.629
  47. Ersoy Tunali N, Tiryakioglu NO (2011). Polymorphisms in the xenobiotic genes and susceptibility to bladder cancer. J Cell Mol Biol, 9, 5-13.
  48. Ersoy Tunali N, Tiryakioglu NO, Cakir OO (2012). Role of xenobiotic metabolizing gene variants in bladder cancer susceptibility. Eur J Cancer, 48, S281.
  49. Figueroa JD, Malats N, Garcia-Closas M, et al (2008). Bladder cancer risk and genetic variation in AKR1C3 and other metabolizing genes. Carcinogenesis, 29, 1955-62. https://doi.org/10.1093/carcin/bgn163
  50. Gonzalez FJ (1997). The role of carcinogen-metabolizing enzyme polymorphisms in cancer susceptibility. Reprod Toxicol, 11, 397-412. https://doi.org/10.1016/S0890-6238(96)00154-2

Cited by

  1. The NAD(P)H: Quinine Oxidoreductase 1 (NQO1) Gene 609 C>T Polymorphism is Associated with Gastric Cancer Risk: Evidence from a Case-control Study and a Meta-analysis vol.15, pp.5, 2014, https://doi.org/10.7314/APJCP.2014.15.5.2363
  2. The Association between NQO1 Pro187Ser Polymorphism and Bladder Cancer Susceptibility: A Meta-Analysis of 15 Studies vol.10, pp.1, 2015, https://doi.org/10.1371/journal.pone.0116500
  3. Gene C609T Polymorphism (dbSNP: rs1800566) and Digestive Tract Cancer Risk: A Meta-Analysis.” vol.70, pp.4, 2018, https://doi.org/10.1080/01635581.2018.1460674