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A 10-year Study of Esophageal Cancer in Guilan Province, Iran: The Guilan Cancer Registry Study (GCRS)

  • Mansour-Ghanaei, Fariborz (Medicine Department, Guilan University of Medical Sciences) ;
  • Heidarzadeh, Abtin (Gastrointestinal and Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences) ;
  • Naghipour, Mohammad Reza (Gastrointestinal and Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences) ;
  • Joukar, Farahnaz (Gastrointestinal and Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences) ;
  • Valeshabad, Ali Kord (Gastrointestinal and Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences) ;
  • Fallah, Mohammad-Sadegh (Gastrointestinal and Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences) ;
  • Rezvani, Seyed Mahmoud (Health Department, Guilan University of Medical Sciences) ;
  • Sedigh-Rahimabadi, Massih (Gastrointestinal and Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences) ;
  • Rokhshad, Hasan (Health Department, Guilan University of Medical Sciences) ;
  • Dadashi, Arsalan (Health Department, Guilan University of Medical Sciences)
  • Published : 2012.12.31

Abstract

Background: Northern Iran counts as one of the highest prevalence regions for esophageal cancer (EC) worldwide. This study was designed to assess the epidemiologic aspects of EC in north central and northwest Iran over a 10 year period. Materials and Methods: The Guilan cancer registry study (GCRS) is a population-based cancer registry study featuring retrospective (1996-2003) and prospective (2004-2005) phases. A detailed questionnaire based on WHO standards for cancer registratration was applied to gather the required information. Two trained physicians coded information using ICD-O-3 in close coordination with an expert pathologist. Results: A total of 19,936 cases of malignancy (mean age $55.4{\pm}18.0$ years, range: 1-98 years) were registered, including 1,147 cases (670 males, 447 female; mean age: $64.0{\pm}11.5$ years) of EC. In 1996 the male/female ratio among patients with EC was 1.25 which increased to 1.53 in 2005. The lower third of the esophagus still remained the most common site of tumors. The average age-standardized rate (ASR) was 6.9 and 4.1 per $10^5$ men and women, respectively. In 1996, the ASRs were 7.2 and 5.2 per $10^5$ men and women which decreased to 6.9 and 4.1 per $10^5$ in 2004-2005. Squamous cell carcinoma (SCC) was the most prevalent histological subtype of EC accounting over 80% of cases. Conclusions: However the prevalence of adenocarcinoma (ADC) showed an increase to 18.4%. Guilan province may be considered a relatively low incidence region for EC.

Keywords

Esophageal cancer;cancer registry study (GCRS);Guilan;Iran

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