- Volume 13 Issue 12
DOI QR Code
SNPs of Excision Repair Cross Complementing Group 5 and Gastric Cancer Risk in Chinese Populations
- Yang, Wan-Guang (Department of Emergency, the First Affiliated Hospital) ;
- Zhang, Shan-Feng (School of Basic Medicine, Zhengzhou University) ;
- Chen, Ju-Wu (Department of Emergency, the First Affiliated Hospital) ;
- Li, Li (Department of Emergency, the First Affiliated Hospital) ;
- Wang, Wan-Peng (Department of Emergency, the First Affiliated Hospital) ;
- Zhang, Xie-Fu (Department of Gastrointestinal Surgery, the First Affiliated Hospital)
- Published : 2012.12.31
We conducted a case-control study to determine the association between several potential SNPs of excision repair cross complementing group 5 (XPG) and gastric cancer susceptibility, and roles of XPG polymorphisms in combination with H.pylori infection in determining risk of gastric cancer. In our study, we collected 337 newly diagnosed gastric cancer cases and 347 health controls. Three SNPs of XPG, rs2296147T>C, rs2094258C>T and rs873601G>A, were genotyped using the Taqman real-time PCR method with a 7900 HT sequence detector system. H. pylori infection was diagnosed by ELISA. By multivariate logistic regression analysis, the rs2296147 CC genotype was associated with a decreased risk of gastric cancer (OR=0.52, 95% CI=0.27-0.97), and rs2094258 TT was associated with elevated risk (OR=2.13, 95% CI=1.22-3.35). Positive H.pylori individuals with rs2094258 TT genotypes demonstrated increased risk of gastric cancer (OR=2.13, 95% CI=1.22-3.35), while rs2296147 CC was associated with lower risk among patients with negative H.pylori (OR=0.45, 95%CI=0.22-0.89). Our findings suggested that XPG polymorphisms might contribute to risk of gastric cancer among Chinese populations, but the effect needs to be further validated by larger sample size studies.
XPG;SNP;gastric cancer;H.pylori;Chinese populations
- Hussain SK, Mu LN, Cai L, et al (2009). Genetic variation in immune regulation and DNA repair pathways and stomach cancer in China. Cancer Epidemiol Biomarkers Prev, 18, 2304-9. https://doi.org/10.1158/1055-9965.EPI-09-0233
- International Agency for Research on Cancer (1994). Schistostomes, liver flukes and Helicobacter pylori. IARC monographs on the evaluation of cancer risks to humans, vol 61. International Agency for Research on Cancer, Lyon.
- International Agency for Research on Cancer (2008). Globocan 2008: Stomach Cancer incidence, Mortality and Prevalence Worldwide in 2008. IARC.
- Kiyohara C, Yoshimasu K (2007). Genetic polymorphisms in the nucleotide excision repair pathway and lung cancer risk: a metaanalysis. Int J Med Sci, 4, 59-71.
- Klungland A, Hoss M, Gunz D, et al (1999). Base excision repair of oxidative DNA damage activated by XPG protein. Mol Cell, 3, 33-42. https://doi.org/10.1016/S1097-2765(00)80172-0
- Liu D, Wu HZ, Zhang YN, et al (2012). DNA repair genes XPC, XPG polymorphisms: Relation to the risk of colorectal carcinoma and therapeutic outcome with oxaliplatin-based adjuvant chemotherapy. Mol Carcinog, 1, E83-93.
- Lu HT, Ouyang WM, Huang CS (2006). Inflammation, a key event in cancer development. Mol Cancer Res, 4, 221-33. https://doi.org/10.1158/1541-7786.MCR-05-0261
- Ma H, Yu H, Liu Z, et al (2012). Polymorphisms of XPG/ERCC5 and risk of squamous cell carcinoma of the head and neck. Pharmacogenet Genomics, 22, 50-7. https://doi.org/10.1097/FPC.0b013e32834e3cf6
- Mueser TC, Nossal NG, Hyde CC (1996). Structure of bacteriophage T4 RNase H, a 50 to 30 RNA-DNA and DNA-DNA exonuclease with sequence similarity to the RAD2 family of eukaryotic proteins. Cell, 85, 1101-12. https://doi.org/10.1016/S0092-8674(00)81310-0
- Pan J, Lin J, Izzo JG, et al (2009). Genetic susceptibility to esophageal cancer: the role of the nucleotide excision repair pathway. Carcinogenesis, 30, 785-92 https://doi.org/10.1093/carcin/bgp058
- Parsonnet J, Friedman GD, Orentreich N, et al (1997). Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection. Gut, 40, 297-301. https://doi.org/10.1136/gut.40.3.297
- Price AB (1991). The Sydney system: histological division. J Gastroenterol Hepatol, 6, 209-22. https://doi.org/10.1111/j.1440-1746.1991.tb01468.x
- Rouissi K, Bahria IB, Bougatef K, et al (2011). The effect of tobacco, XPC, ERCC2 and ERCC5 genetic variants in bladder cancer development. BMC Cancer, 11, 101. https://doi.org/10.1186/1471-2407-11-101
- Singh K, Ghoshal UC (2006). Causal role of Helicobacter pylori infection in gastric cancer: an Asian enigma. World J Gastroenterol, 12, 1346-51.
- Sipponen P, Marshall BJ (2000). Gastritis and gastric cancer. Western countries. Gastroenterol Clin North Am, 29, 579-92. https://doi.org/10.1016/S0889-8553(05)70131-X
- Zhu ML, Shi TY, Hu HC, et al (2012). Polymorphisms in the ERCC5 gene and risk of esophageal squamous cell carcinoma (ESCC) in Eastern Chinese populations. PLoS One, 7, e41500. https://doi.org/10.1371/journal.pone.0041500
- Zhu ML, Wang M, Cao ZG, et al (2012). Association between the ERCC5 Asp1104His polymorphism and cancer risk: a metaanalysis. PLoS One, 7, e36293. https://doi.org/10.1371/journal.pone.0036293
- Chang JS, Wrensch MR, Hansen HM, et al (2008). Nucleotide excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African Americans. Int J Cancer, 123, 2095-104. https://doi.org/10.1002/ijc.23801
- Correa P (1992). Human Gastric carcinogenesis: a multistep and multifactorial process: first American Cancer Society award lecture on cancer epidemiology and prevention. Cancer Res, 52, 6735-40.
- Correa P (1997). Helicobacter pylori as a pathogen and carcinogen. J Physiol Pharmacol, 48, 19-24.
- Coussens LM, Werb Z (2002). Inflammation and cancer. Nature, 420, 860-7. https://doi.org/10.1038/nature01322
- Dixon MF, Genta RM, Yardley JH, et al (1996). Classification and grading of gastritis: the updated Sydney system. Am J Surg Pathol, 20, 1161-81.
- Duan Z, He C, Gong Y, et al (2012). Promoter polymorphisms in DNA repair gene ERCC5 and susceptibility to gastric cancer in Chinese. Gene, 511, 274-9. https://doi.org/10.1016/j.gene.2012.09.025
- Farinati F, Cardin R, Cassaro M, et al (2008). Helicobacter pylori, inflammation, oxidative damage and gastric cancer: a morphological, biological and molecular pathway. Eur J Cancer Prev, 17, 195-200. https://doi.org/10.1097/CEJ.0b013e3282f0bff5
- Friedberg EC, Bond JP, Burns DK, et al (2000). Defective nucleotide excision repair in XPC mutant mice and its association with cancer predisposition. Mutat Res, 459, 99-108. https://doi.org/10.1016/S0921-8777(99)00068-3
- Ghoshal UC, Tiwari S, Dhingra S, et al (2008). Frequency of Helicobacter pylori and CagA antibody in patients with gastric neoplasm and controls: the Indian enigma. Dig Dis Sci, 53, 1215-22. https://doi.org/10.1007/s10620-008-0229-7
- Ghoshal UC, Tripathi S, Ghoshal U (2007). The Indian enigma of frequent H. pylori infection but infrequent gastric cancer: is the magic key in Indian diet, host's genetic make up, or friendly bug? Am J Gastroenterol, 102, 2113-4. https://doi.org/10.1111/j.1572-0241.2007.01324_13.x
- Graham DY, Adam E, Reddy GT, et al (1991). Seroepidemiology of Helicobacter pylori infection in India; comparison of developing and developing countries. Dig Dis Sci, 36, 1084-8. https://doi.org/10.1007/BF01297451
- He J, Qiu LX, Wang MY, et al (2012). Polymorphisms in the XPG gene and risk of gastric cancer in Chinese populations. Hum Genet, 131, 1235-44. https://doi.org/10.1007/s00439-012-1152-8
- polymorphisms and stomach cancer susceptibility in a Chinese population vol.20, pp.5, 2016, https://doi.org/10.1111/jcmm.12773
- gene with neuroblastoma risk in a Chinese population vol.20, pp.8, 2016, https://doi.org/10.1111/jcmm.12836
- The association between XPG polymorphisms and cancer susceptibility vol.96, pp.32, 2017, https://doi.org/10.1097/MD.0000000000007467
- Association between the polymorphisms in XPG gene and gastric cancer susceptibility in Chinese populations vol.96, pp.42, 2017, https://doi.org/10.1097/MD.0000000000008213
- Association between the XPG gene rs2094258 polymorphism and risk of gastric cancer vol.32, pp.8, 2018, https://doi.org/10.1002/jcla.22564