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Lack of Increased P15INK4B Protein Expression in Basal Cell Carcinomas

  • Moad, Ahmed Ismail Hassan (Advanced Medical and Dental Institute, University Sains Malaysia) ;
  • Tan, Mei Lan (Advanced Medical and Dental Institute, University Sains Malaysia) ;
  • Kaur, Gurjeet (Institute for Research in Molecular Medicine, Universiti Sains Malaysia) ;
  • Mabruk, Mohamed (APRSP Institute of health Sciences, University of Brunei Darussalam)
  • Published : 2012.12.31

Abstract

Background: The basal cell carcinoma (BCC) is the most common non-melanoma skin cancer (NMSK). BCC might develop because of the faulty cell cycle arrest. $p15^{INK4b}$ is a tumor suppressor gene, involved in cell cycle arrest and inactivated in most human cancers. The role of $p15^{INK4b}$ protein expression in the genesis of BCC is as yet unknown. In a previous study we showed the absence of $p15^{INK4b}$ expression in the majority of tissue microarray cores of cutaneous squamous cell carcinoma (SCCs), another type of non-melanoma skin cancer, indicating that $p15^{INK4b}$ could possibly be involved in the pathogenesis of cutaneous SCC. The aim of this study was to investigate $p15^{INK4b}$ protein expression in BCCs. Materials and Method: Protein expression of $p15^{INK4b}$ in 35 cases of BCC tissue arrays and 19 cases of normal human skin tissue was studied using an immunohistochemical approach. Results: The expression of $p15^{INK4b}$ was not significantly different in the BCC cases as compared with normal human skin (p=0.356; p>0.05). In addition, there were no significant relationship between clinicopathologic variables of patients (age and sex) and $p15^{INK4b}$ protein expression. Conclusions: Our finding may indicate that $p15^{INK4b}$ protein expression does not play a role in the genesis of BCC.

Keywords

Basal cell carcinoma;$p15^{INK4b}$;immunohistichemistry

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