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Prevalence and Co-infection of Intestinal Parasites among Thai Rural Residents at High-risk of Developing Cholangiocarcinoma: A Cross-sectional Study in a Prospective Cohort Study

  • Songserm, Nopparat (Department of Epidemiology, Faculty of Public Health, Khon Kaen University) ;
  • Promthet, Supannee (Department of Epidemiology, Faculty of Public Health, Khon Kaen University) ;
  • Wiangnon, Surapon (Department of Paediatrics, Faculty of Medicine, Khon Kaen University) ;
  • Sithithaworn, Paiboon (Department of Parasitology, Faculty of Medicine, Khon Kaen University)
  • Published : 2012.12.31

Abstract

Intestinal parasitic infections (IPIs) are still important to the health of Thai rural residents. IPIs are the cause of many chronic diseases with, for example, opisthorchiasis resulting in progression to cholangiocarcinoma (CCA). This cross-sectional study in a prospective cohort study aimed to examine the prevalence and co-infection of intestinal parasites among Northeastern Thai rural residents, recruited into the Khon Kaen Cohort Study (KKCS), and who were residing in areas of high-risk for developing CCA. On recruitment, subjects had completed questionnaires and provided fecal samples for IPI testing using the formalin ethyl acetate concentration technique. Data on selected general characteristics and the results of the fecal tests were analysed. IPI test results were available for 18,900 of cohort subjects, and 38.50% were found to be positive for one or more types of intestinal parasite. The prevalence of Opisthorchis viverrini (O. viverrini) infection was the highest (45.7%), followed by intestinal flukes (31.9%), intestinal nematodes (17.7%), intestinal protozoa (3.02%), and intestinal cestodes (1.69%). The pattern of different infections was similar in all age groups. According to a mapping analysis, a higher CCA burden was correlated with a higher prevalence of O. viverrini and intestinal flukes and a greater intensity of O. viverrini. Both prevention and control programs against liver fluke and other intestinal parasites are needed and should be delivered simultaneously. We can anticipate that the design of future control and prevention programmes will accommodate a more community-orientated and participatory approach.

Keywords

Prevalence;co-infection;intestinal parasites;cholangiocarcinoma;Thailand

References

  1. Srivatanakul P, Ohshima H, Khlat M, et al (1991). Opisthorchis viverrini infestation and endogenous nitrosamines as risk factors for cholangiocarcinoma in Thailand. Int J Cancer, 48, 821-5. https://doi.org/10.1002/ijc.2910480606
  2. Steketee RW (2003). Pregnancy, nutrition and parasitic diseases. J Nutr, 133, 1661-7.
  3. Vatanasapt V, Uttaravichien T, Mairiang EO, et al (1990). Cholangiocarcinoma in north-east Thailand. Lancet, 335, 116-7.
  4. Haswell-Elkins MR, Mairiang E, Mairiang P, et al (1994). Cross-sectional study of Opisthorchis viverrini infection and cholangiocarcinoma in communities within a high-risk area in northeast Thailand. Int J Cancer, 59, 505-9. https://doi.org/10.1002/ijc.2910590412
  5. Intapan PM, Maleewong W, Wongsaroj T, Singthong S, Morakote N (2005). Comparison of the quantitative formalin ethyl acetate concentration technique and agar plate culture for diagnosis of human strongyloidiasis. J Clin Microbiol, 43, 1932-3. https://doi.org/10.1128/JCM.43.4.1932-1933.2005
  6. Jongsuksuntigul P, Imsomboon T (1998). Epidemiology of opisthorchiasis and national control program in Thailand. Southeast Asian J Trop Med Public Hlth, 29, 327-32.
  7. Jongsuksuntigul P, Imsomboon T (2003). Opisthorchiasis control in Thailand. Acta Trop, 88, 229-32. https://doi.org/10.1016/j.actatropica.2003.01.002
  8. Koukounari A, Estambale BB, Njagi JK, et al (2008). Relationships between anaemia and parasitic infections in Kenyan schoolchildren: a Bayesian hierarchical modelling approach. Int J Parasitol, 38, 1663-71. https://doi.org/10.1016/j.ijpara.2008.05.013
  9. Kurathong S, Brockelman WY, Lerdverasirikul P, et al (1984). Consistency of fecal egg output in patients with Opisthochiasis viverrini. Am J Trop Med Hyg, 33, 73-5.
  10. Mehraj V, Hatcher J, Akhtar S, Rafique G, Beg MA (2008). Prevalence and factors associated with intestinal parasitic infection among children in an urban slum of Karachi. PLoS ONE, 3, 3680. https://doi.org/10.1371/journal.pone.0003680
  11. Nyarango RM, Aloo PA, Kabiru EW, Nyanchongi BO (2008). The risk of pathogenic intestinal parasite infections in Kisii Municipality, Kenya. BMC Public Hlth, 8, 237. https://doi.org/10.1186/1471-2458-8-237
  12. Parkin DM, Oshima H, Srivatanakul P, Vatanasapt V (1993). Cholangiocarcinoma: epidemiology, mechanism of carcinogenesis and prevention. Cancer Epidemiol Biomarkers Prev, 2, 537-44.
  13. Parkin DM, Srivatanakul P, Khlat M, et al (1991). Liver cancer in Thailand. I. A case-control study of cholangiocarcinoma. Int J Cancer, 48, 323-8. https://doi.org/10.1002/ijc.2910480302
  14. Sayasone S, Vonghajack Y, Vanmany M, et al (2009). Diversity of human intestinal helminthiasis in Lao PDR. Trans R Soc Trop Med Hyg, 103, 247-54. https://doi.org/10.1016/j.trstmh.2008.10.011
  15. Sithithaworn P, Andrews RH, Nguyen VD, et al (2012). The current status of opisthorchiasis and clonorchiasis in the Mekong Basin. Parasitol Int, 61, 10-6. https://doi.org/10.1016/j.parint.2011.08.014
  16. Sithithaworn P, Sukavat K, Vannachone B, et al (2006). Epidemiology of food-borne trematodes and other parasite infections in a fishing community on the Nam Ngum reservoir, Lao PDR. Southeast Asian J Trop Med Public Hlth, 37, 1083-90.
  17. Sriamporn S, Parkin DM, Pisani P, et al (2005). A prospective study of diet, lifestyle, and genetic factors and the risk of cancer in Khon Kaen Province, northeast Thailand: description of the cohort. Asian Pac J Cancer Prev, 6, 295-303.
  18. Sriamporn S, Pisani P, Pipitgool V, et al (2004). Prevalence of Opisthorchis viverrini infection and incidence of cholangiocarcinoma in Khon Kaen, Northeast Thailand. Trop Med Int Hlth, 9, 588-94. https://doi.org/10.1111/j.1365-3156.2004.01234.x
  19. Sripa B, Kaewkes S, Sithithaworn P, et al (2007). Liver fluke induces cholangiocarcinoma. PLoS Med, 4, 201. https://doi.org/10.1371/journal.pmed.0040201
  20. Albonico M, De Carneri I, Di Matteo L, et al (1993). Intestinal parasitic infections of urban and rural children on Pemba Island: implications for control. Ann Trop Med Parasitol, 87, 579-83.
  21. Carme B, Motard A, Bau P, et al (2002). Intestinal parasitoses among Wayampi Indians from French Guiana. Parasite, 9, 167-74. https://doi.org/10.1051/parasite/2002092167
  22. Carvalho-Costa FA, Goncalves AQ, Lassance SL, et al (2007). Giardia lamblia and other intestinal parasitic infections and their relationships with nutritional status in children in Brazilian Amazon. Rev Inst Med Trop Sao Paulo, 49, 147-53. https://doi.org/10.1590/S0036-46652007000300003
  23. Curtale F, Pezzotti P, Sharbini AL, et al (1998). Knowledge, perceptions and behaviour of mothers toward intestinal helminths in Upper Egypt: implications for control. Hlth Policy Plan, 13, 423-32. https://doi.org/10.1093/heapol/13.4.423
  24. Elkins DB, Haswell-Elkins MR, Mairiang E, et al (1990). A high frequency of hepatobiliary disease and suspected cholangiocarcinoma associated with heavy Opisthorchis viverrini infection in a small community in north-east Thailand. Trans R Soc Trop Med Hyg, 84, 715-9. https://doi.org/10.1016/0035-9203(90)90159-C
  25. Grundy-Warr C, Andrews RH, Sithithaworn P, et al (2012). Raw attitudes, wetland cultures, life-cycles: socio-cultural dynamics relating to Opisthorchis viverrini in the Mekong Basin. Parasitol Int, 61, 65-70. https://doi.org/10.1016/j.parint.2011.06.015
  26. Harinasuta C, Sornamani S, Migasena P, et al (1976). Socioeconomic, health and nutritional status of the villagers in the Nong Wai irrigation area, Khon Kaen, Northeast Thailand. Southeast Asian J Trop Med Public Hlth, 7, 601-21.

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