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Human Papilloma Virus Attributable Head and Neck Cancer in the Sudan Assessed by p16INK4A Immunostaining

  • Ahmed, Hussain Gadelkarim (Department of Pathology, College of Medicine, University of Hail) ;
  • Mustafa, Saadalnour Abusail (Department of Histopathology and Cytology, Faculty of Medical laboratory Sciences, Elneelain University) ;
  • Warille, Eyman (Department of Pathology, College of Medicine, University of Hail)
  • Published : 2012.12.31

Abstract

Background: The aim of this study was to screen for human papillomavirus (HPV) infections in head and neck squamous cell carcinomas (HNSCCs) using P16 immunostaining. Materials and Methods: A retrospective study was performed on 150 samples from patients diagnosed with HNSCCs. HPV status was determined using $p16^{INK4A}$. Results: 31 of the 150 (20.7%) HNSCCs were HPV positive. Conclusions: A large proportion of HNSCCs in Sudan are associated with HPV infection. The fact that the prevalence of HPV is high among Sudanese patients with head and neck cancers (HNC) has obvious implications for vaccine therapy.

Keywords

Head and neck cancer;human papillomavirus;$p16^{INK4A}$;Sudan

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