- Volume 13 Issue 12
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Pretreatment Thrombocytosis as a Prognostic Factor in Women with Gynecologic Malignancies: a Meta-analysis
- Yu, Min (Department of Cancer Center, State Key Laboratory of Biotherapy) ;
- Liu, Lei (Department of Cancer Center, State Key Laboratory of Biotherapy) ;
- Zhang, Bing-Lan (Department of Cancer Center, State Key Laboratory of Biotherapy) ;
- Chen, Qi (Department of Cancer Center, State Key Laboratory of Biotherapy) ;
- Ma, Xue-Lei (Department of Cancer Center, State Key Laboratory of Biotherapy) ;
- Wu, Yu-Ke (Department of Cancer Center, State Key Laboratory of Biotherapy) ;
- Liang, Chun-Shui (Department of Cancer Center, State Key Laboratory of Biotherapy) ;
- Niu, Zhi-Min (Department of Cancer Center, State Key Laboratory of Biotherapy) ;
- Qin, Xin (Department of Cancer Center, State Key Laboratory of Biotherapy) ;
- Niu, Ting (Department of Hematology, West China Hospital, Sichuan University)
- Published : 2012.12.31
Background: This study was performed to analyze the prognostic implications of pretreatment or preoperative thrombocytosis in women with gynecologic malignancies. Material and Methods: We surveyed 2 medical databases, PubMed and EMBASE, to identified all relevant studies. A total of 14 (n=3,490) that evaluated the link between thrombocytosis and 5-year survival were included. REVMAN version 5.1 was used for our analysis and publication bias was evaluated using the Begg's funnel plot and tested by STATA 11.0. Risk ratios (RRs) with 95% confidence intervals (CIs) generated by the random effect model were used to assess the strength of any association. Results: 709(20.3%) of the 3,490 patients exhibited thrombocytosis (platelet counts >
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