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Association between Mismatch Repair Gene MSH3 codons 1036 and 222 Polymorphisms and Sporadic Prostate Cancer in the Iranian Population

  • Jafary, Fariba (Young Researcher Club. I.A.U. Falavarjan University) ;
  • Salehi, Mansoor (Division of Genetics, Department of Biomedical Sciences, Isfahan University of Medical Sciences) ;
  • Sedghi, Maryam (Medical Genetics Laboratory, Alzahra Hospital. Medical University of Medical Sciences) ;
  • Nouri, Nayereh (Medical Genetics Laboratory, Alzahra Hospital. Medical University of Medical Sciences) ;
  • Jafary, Farzaneh (Biology Department, Faculty of Basic Science, Alzahra Univercity) ;
  • Sadeghi, Farzaneh (Department of Anatomical Sciences, Medical School, Isfahan University of Medical Sciences) ;
  • Motamedi, Shima (School of Veterinary Medicine, Razi University) ;
  • Talebi, Maede (Young Researcher Club. I.A.U. Falavarjan University)
  • Published : 2012.12.31

Abstract

The mismatch repair system (MMR) is a post-replicative DNA repair mechanism whose defects can lead to cancer. The MSH3 protein is an essential component of the system. We postulated that MSH3 gene polymorphisms might therefore be associated with prostate cancer (PC). We studied MSH3 codon 222 and MSH3 codon 1036 polymorphisms in a group of Iranian sporadic PC patients. A total of 60 controls and 18 patients were assessed using the polymerase chain reaction and single strand conformational polymorphism. For comparing the genotype frequencies of patients and controls the chi-square test was applied. The obtained result indicated that there was significantly association between G/A genotype of MSH3 codon 222 and G/G genotype of MSH3 codon 1036 with an increased PC risk (P=0.012 and P=0.02 respectively). Our results demonstrated that MSH3 codon 222 and MSH3 codon 1036 polymorphisms may be risk factors for sporadic prostate cancer in the Iranian population.

Keywords

Sporadic prostate cancer;polymorphism;DNA mismatch repair;MSH3;Iran

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