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Identification of Genetic and Non-genetic Risk Factors for Nasopharyngeal Carcinoma in a Southeast Asian Population

  • Hashim, Nikman Adli Nor (Molecular Research and Services Laboratory, INFOVALLEY(R) Life Sciences Sdn. Mines Resort City) ;
  • Ramzi, Nurul Hanis (Molecular Research and Services Laboratory, INFOVALLEY(R) Life Sciences Sdn. Mines Resort City) ;
  • Velapasamy, Sharmila (Molecular Research and Services Laboratory, INFOVALLEY(R) Life Sciences Sdn. Mines Resort City) ;
  • Alex, Livy (Molecular Research and Services Laboratory, INFOVALLEY(R) Life Sciences Sdn. Mines Resort City) ;
  • Chahil, Jagdish Kaur (Molecular Research and Services Laboratory, INFOVALLEY(R) Life Sciences Sdn. Mines Resort City) ;
  • Lye, Say Hean (Molecular Research and Services Laboratory, INFOVALLEY(R) Life Sciences Sdn. Mines Resort City) ;
  • Munretnam, Khamsigan (Molecular Research and Services Laboratory, INFOVALLEY(R) Life Sciences Sdn. Mines Resort City) ;
  • Haron, Mohd Roslan (Department of Radiotherapy and Oncology, Hospital Sultan Ismail) ;
  • Ler, Lian Wee (Molecular Research and Services Laboratory, INFOVALLEY(R) Life Sciences Sdn. Mines Resort City)
  • Published : 2012.12.31

Abstract

Background: Nasopharyngeal carcinoma (NPC) is endemic in Southern Chinese and Southeast Asian populations. Geographical and ethnic clustering of the cancer is due to genetic, environmental, and lifestyle risk factors. This case-control study aimed to identify or confirm both genetic and non-genetic risk factors for NPC in one of the endemic countries, Malaysia. Materials and Methods: A panel of 768 single-nucleotide polymorphisms (SNPs) previously associated with various cancers and known non-genetic risk factors for NPC were selected and analyzed for their associations with NPC in a case-control study. Results: Statistical analysis identified 40 SNPs associated with NPC risk in our population, including 5 documented previously by genome-wide association studies (GWAS) and other case-control studies; the associations of the remaining 35 SNPs with NPC were novel. In addition, consistent with previous studies, exposure to occupational hazards, overconsumption of salt-cured foods, red meat, as well as low intake of fruits and vegetables were also associated with NPC risk. Conclusions: In short, this study confirmed and/or identified genetic, environmental and dietary risk factors associated with NPC susceptibility in a Southeast Asian population.

Keywords

SNP;nasopharyngeal carcinoma;association study;cancer risk;Southeast Asia

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