- Volume 13 Issue 12
DOI QR Code
MMP1 rs1799750 Single Nucleotide Polymorphism and Lung Cancer Risk: A Meta-analysis
- Hu, Jiang (Department of Oncology, Taihe Hospital Affiliated with Hubei University of Medicine) ;
- Pan, Jun (Department of Oncology, Taihe Hospital Affiliated with Hubei University of Medicine) ;
- Luo, Zhi-Guo (Department of Oncology, Taihe Hospital Affiliated with Hubei University of Medicine)
- Published : 2012.12.31
Background: Numerous studies have investigated the association of matrix metalloproteinase 1 (MMP1) rs1799750 single nucleotide polymorphism with lung cancer susceptibility, but the findings are inconsistent. Therefore, we performed a meta-analysis to comprehensively evaluate any possible association. Methods: We searched publications from MEDLINE, EMBASE and CNKI databases which assessed links between the MMP1 rs1799750 polymorphism and lung cancer risk. We calculated the pooled odds ratio (OR) and its 95% confidence interval (95%CI) using either fixed-effects or random-effects models. Results: The meta-analysis was based on 9 publications encompassing 4,823 cases and 4,298 controls. The overall results suggested there was a significant association between the MMP1 rs1799750 polymorphism and lung cancer risk (1G vs. 2G: OR = 0.83, 95%CI = 0.73-0.94; 1G1G vs. 2G2G: OR = 0.73, 95%CI = 0.59-0.92; 1G1G vs. 1G2G/2G2G: OR = 0.87, 95%CI = 0.79-0.97; 1G1G/1G2G vs. 2G2G: OR = 0.78, 95%CI = 0.64-0.95). In the subgroup analysis by ethnicity, the association was still obvious in Asians (all P values < 0.05), but there was no association in Caucasians (all P values > 0.05). Conclusions: The MMP1 rs1799750 polymorphism is associated with decreased lung cancer risk, and a race-specific effect may exist in this association.
MMP1;lung cancer;single nucleotide polymorphism;meta;analysis;ethnic groups
- Zhang WQ, Lin H, Zhou YA, et al (2006). [Association of MMP1 -1607(1G>2G) single nucleotide polymorphism with susceptibility to lung cancer in Northwestern Chinese population of Han nationality]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 23, 313-5.
- Zhou J, Brinckerhoff C, Lubert S, et al (2011). Analysis of matrix metalloproteinase-1 gene polymorphisms and expression in benign and malignant breast tumors. Cancer Invest, 29, 599-607. https://doi.org/10.3109/07357907.2011.621915
- Zhou Y, Yu C, Miao X, et al (2005). Functional haplotypes in the promoter of matrix metalloproteinase-2 and lung cancer susceptibility. Carcinogenesis, 26, 1117-21. https://doi.org/10.1093/carcin/bgi057
- Zhu Y, Spitz MR, Lei L, et al (2001). A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter enhances lung cancer susceptibility. Cancer Res, 61, 7825-9.
- Gonzalez-Arriaga P, Lopez-Cima MF, Fernandez-Somoano A, et al (2008). Polymorphism +17 C/G in matrix metalloprotease MMP8 decreases lung cancer risk. BMC Cancer, 8, 378. https://doi.org/10.1186/1471-2407-8-378
- Hart K, Landvik NE, Lind H, et al (2011). A combination of functional polymorphisms in the CASP8, MMP1, IL10 and SEPS1 genes affects risk of non-small cell lung cancer. Lung Cancer, 71, 123-9. https://doi.org/10.1016/j.lungcan.2010.04.016
- Herbst RS, Heymach JV, Lippman SM (2008). Lung cancer. N Engl J Med, 359, 1367-80. https://doi.org/10.1056/NEJMra0802714
- Higgins JP, Thompson SG, Deeks JJ, et al (2003). Measuring inconsistency in meta-analyses. BMJ, 327, 557-60. https://doi.org/10.1136/bmj.327.7414.557
- Jemal A, Bray F, Center MM, et al (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90. https://doi.org/10.3322/caac.20107
- Kimman M, Norman R, Jan S, et al (2012). The Burden of Cancer in Member Countries of the Association of Southeast Asian Nations (ASEAN). Asian Pac J Cancer Prev, 13, 411-20. https://doi.org/10.7314/APJCP.2012.13.2.411
- Liu D, Duan W, Guo H, et al (2011). Meta-analysis of associations between polymorphisms in the promoter regions of matrix metalloproteinases and the risk of colorectal cancer. Int J Colorectal Dis, 26, 1099-105. https://doi.org/10.1007/s00384-011-1198-4
- Liu D, Guo H, Li Y, et al (2012). Association between polymorphisms in the promoter regions of matrix metalloproteinases (MMPs) and risk of cancer metastasis: a meta-analysis. PLoS One, 7, e31251. https://doi.org/10.1371/journal.pone.0031251
- Liu L, Wu J, Wu C, et al (2011). A functional polymorphism (-1607 1G-->2G) in the matrix metalloproteinase-1 promoter is associated with development and progression of lung cancer. Cancer, 117, 5172-81. https://doi.org/10.1002/cncr.26154
- Mantel N, Haenszel W (1959). Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst, 22, 719-48.
- Nelson AR, Fingleton B, Rothenberg ML, et al (2000). Matrix metalloproteinases: biologic activity and clinical implications. J Clin Oncol, 18, 1135-49.
- Peng B, Cao L, Wang W, et al (2010). Polymorphisms in the promoter regions of matrix metalloproteinases 1 and 3 and cancer risk: a meta-analysis of 50 case-control studies. Mutagenesis, 25, 41-8. https://doi.org/10.1093/mutage/gep041
- Sauter W, Rosenberger A, Beckmann L, et al (2008). Matrix metalloproteinase 1 (MMP1) is associated with early-onset lung cancer. Cancer Epidemiol Biomarkers Prev, 17, 1127-35. https://doi.org/10.1158/1055-9965.EPI-07-2840
- Su L, Zhou W, Asomaning K, et al (2006). Genotypes and haplotypes of matrix metalloproteinase 1, 3 and 12 genes and the risk of lung cancer. Carcinogenesis, 27, 1024-9. https://doi.org/10.1093/carcin/bgi283
- Wei W, Liang X, Weng X (2007). The association of MMP-1-1607(1 G-2G) single nucleotide polymorpllism with the susceptibility to non-small cell lung carcinoma in Guizhou Han Nationality. JOURNAL OF GUIYANG MEDICAL COLLEGE, 32, 267-70.
- Xiao H, Ding J, Gao S, et al (2011). Never smokers with lung cancer: analysis of genetic variants. Asian Pac J Cancer Prev, 12, 2807-9.
- Yamamura T, Nakanishi K, Hiroi S, et al (2002). Expression of membrane-type-1-matrix metalloproteinase and metalloproteinase-2 in nonsmall cell lung carcinomas. Lung Cancer, 35, 249-55. https://doi.org/10.1016/S0169-5002(01)00431-7
- Attia J, Thakkinstian A, D'Este C (2003). Meta-analyses of molecular association studies: methodologic lessons for genetic epidemiology. J Clin Epidemiol, 56, 297-303. https://doi.org/10.1016/S0895-4356(03)00011-8
- Brennan P, Hainaut P, Boffetta P (2011). Genetics of lung-cancer susceptibility. Lancet Oncol, 12, 399-408. https://doi.org/10.1016/S1470-2045(10)70126-1
- Cheng X (2007). Correlation of single nucleotide polymorphism in the matrix metallola'oteinase-1 promoter region (-1607)1G/2G with risk of lung cancer. J Shangxi Med Univ, 38, 777-9.
- Chen Y, Nixon NB, Dawes PT, et al (2012). Influence of variations across the MMP-1 and -3 genes on the serum levels of MMP- 1 and -3 and disease activity in rheumatoid arthritis. Genes Immun, 13, 29-37. https://doi.org/10.1038/gene.2011.46
- DerSimonian R, Laird N (1986). Meta-analysis in clinical trials. Control Clin Trials, 7, 177-88. https://doi.org/10.1016/0197-2456(86)90046-2
- Egeblad M, Werb Z (2002). New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer, 2, 161-74. https://doi.org/10.1038/nrc745
- Fang S, Jin X, Wang R, et al (2005). Polymorphisms in the MMP1 and MMP3 promoter and non-small cell lung carcinoma in North China. Carcinogenesis, 26, 481-6.
- Goldstraw P, Ball D, Jett JR, et al (2011). Non-small-cell lung cancer. Lancet, 378, 1727-40. https://doi.org/10.1016/S0140-6736(10)62101-0
- Matrix metalloproteinases and genetic mouse models in cancer research: a mini-review vol.36, pp.1, 2015, https://doi.org/10.1007/s13277-014-2747-6
- The polymorphism MMP1 −1607 (1G>2G) is associated with a significantly increased risk of cancers from a meta-analysis vol.36, pp.3, 2015, https://doi.org/10.1007/s13277-014-2769-0