- Volume 13 Issue 12
DOI QR Code
Statistical Approach to Discovery of Factors Impacting on Emergence of Blood Cancers in Iran
- Zand, Ali Mohammad (Department of Biology, Basic Science Faculty, IHU) ;
- Imani, Saber (Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences) ;
- Saadati, Mojtaba (Department of Biology, Basic Science Faculty, IHU) ;
- Ziaei, Robabeh (Blood Department, Hematology and Oncology Research Center) ;
- Borna, Hojat (Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences) ;
- Zaefizadeh, Mohammad (Ardabil Branch, Islamic Azad University) ;
- Shazad, Babak (Imam Khomeini Hospital)
- Published : 2012.12.31
Cancer is now the main cause of increasing mortality throughout the world. Minor alterations in the cell cycle which are inherited and not removed by apoptosis are important rsik factors. Blood cancers are asmong the types which most readily cause death. Here in this study, usual but important factors such as age, gender, Rh and ABO blood typing, weight, and platelet counts are analyzed for impact on blood cancers. Frequencies and distributions, correlations and chi-square test were utilized in order to clarify the perspective of important factors. Our statistical results show males and females to have same risk in blood cancer but A blood type (40%) along with positive Rh (73%) had the highest risk. Low platelet counts are related to more than 80% of cases. Obesity has a statistically ignorable role in blood cancer prevalence. The fact that blood cancer cases increase during the second decade of life (45.7%) which might be because of involvement of maturation processes.
Blood cancer;statistical approach;age;gender
- Sandler DP, (1995). Recent studies in leukemia epidemiology. Curr Opin Oncol, 7, 12-8. https://doi.org/10.1097/00001622-199501000-00003
- SEER Cancer Statistics Review 1975-2008 (2011). http://seer.cancer.gov/csr/1975_2008/, based on November 2010 SEER data submission, posted to the SEER web site.
- World Health Organization (2009). Global health risks: mortality and burden of disease attributable to selected major risks. ISBN: 978-92-4-156387-1.
- Zand AM, Imani S, Sa'adati M, et al (2010). Effect of age, gender and blood group on different types of leukemia. Kowsar Med J, 15, 111-4.
- American Cancer Society, (2011). Cancer Facts and Figures 2011, Atlanta, Ga: American Cancer Society.
- Greaves MF, Colman SM, Beard ME, et al (1993). Geographical distribution of acute lymphoblastic leukaemia subtypes: second report of the collaborative group study. Leukemia, 7, 27-34.
- Howlader N, Noone AM, Krapcho M, et al (2008). SEER Cancer Statistics Review, National Cancer Institute.
- Jackson N, Menon BS, Zarina W, Zawiwi N (1999). Why is acute leukemia more common in males? A possible gender determined risk linked to the ABO blood group genes. Ann Hematol J, 78, 233-6. https://doi.org/10.1007/s002770050507
- Jemal A, Thun MJ, Ries LA, et al (2008). Annual report to the nation on the status of cancer, 1975-2005, featuring trends in lung cancer, tobacco use and tobacco control. J Natl Canc Inst, 100, 1672-94. https://doi.org/10.1093/jnci/djn389
- Lowenberg B (2008). Acute myeloid leukemia: the challenge of capturing disease variety. Hematology, 10, 1-11.
- Nishi M, Miyake H, Takeda T, Shimada M (1996). Epidemiology of childhood leukemia in Hokkaido, Japan. Int J Cancer, 67, 323-6. https://doi.org/10.1002/(SICI)1097-0215(19960729)67:3<323::AID-IJC3>3.0.CO;2-T
- Rai KR, Holland JF, Glidewell OJ, et al (1981). Treatment of acute myelocytic leukemia: a study by cancer and leukemia group B. Blood, 58, 1203-12.
- Ron E, Preston DL, Mabuchiad K, Desmond E, Sodaf M (1994). Cancer incidence in atomic bomb survivors Part IV: Comparison of cancer incidence and mortality. Radiat Res, 137, 98-112. https://doi.org/10.2307/3578894
- Assessment of Relationship between Wilms' Tumor Gene (WT1) Expression in Peripheral Blood of Acute Leukemia Patients and Serum IL-12 and C3 Levels vol.16, pp.16, 2015, https://doi.org/10.7314/APJCP.2015.16.16.7303