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Effects of Stressful Life Events on Patients with Recurrent Ahthous Ulcer.

SRRS를 이용한 재발성 아프타성 구내궤양 환자의 생활변화에 관한 연구

  • Ko, Myung-Yun (Department of Oral Medicine, School of Dentistry, Busan National University) ;
  • Kim, Young-Ae (Department of Oral Medicine, School of Dentistry, Busan National University) ;
  • Ok, Soo-Min (Department of Oral Medicine, School of Dentistry, Busan National University) ;
  • Heo, Jun-Young (Department of Oral Medicine, School of Dentistry, Busan National University) ;
  • Jeong, Sung-Hee (Department of Oral Medicine, School of Dentistry, Busan National University) ;
  • Ahn, Yong-Woo (Department of Oral Medicine, School of Dentistry, Busan National University)
  • 고명연 (부산대학교 치의학전문대학원 구강내과학 교실) ;
  • 김영애 (부산대학교 치의학전문대학원 구강내과학 교실) ;
  • 옥수민 (부산대학교 치의학전문대학원 구강내과학 교실) ;
  • 허준영 (부산대학교 치의학전문대학원 구강내과학 교실) ;
  • 정성희 (부산대학교 치의학전문대학원 구강내과학 교실) ;
  • 안용우 (부산대학교 치의학전문대학원 구강내과학 교실)
  • Received : 2012.11.11
  • Accepted : 2012.11.27
  • Published : 2012.12.30

Abstract

Recurrent aphthous ulcer(RAU) is the most frequent form of oral ulceration with a prevalence in the general population ranging between 5% and 60%. The peak age of onset is between 10 and 19 years of age, and it can persist into adulthood and throughout the patient's lifespan, with no gender predilection. The disease is characterized clinically into three types: minor aphthous ulcer, major aphthous ulcer and herpeticform ulcers. The cause of RAU is unknown and thought to be multifactorial with many triggers or precipitating factors that include familial tendency or genetic predisposition, allergy, medications, hormones, stress or anxiety, and immunologic abnormalities. The need for consideration of psychological factors in the pathogenesis of oral disease has been increasingly acknowledged over the last decades and many studies have highlighted the psycho-social impact of oral conditions. In this study, we tried to evaluate the influence of emotional stress in RAU. There were thirty patients with a clinical diagnosis of RAU and other subjects who did not show any signs of systemic disorders include RAU. They are evaluated by using modified Holmes and Rahe's Social Readjustment Rating Scale (SRRS). As a result, a significantly higher level of stress was found in the RAU patients than the control group. Therefore it can be concluded that psychological stressors play an important role in the RAU.

Keywords

Recurrent aphthous ulcer;Social readjustment rating scale (SRRS);Stressful life events

Acknowledgement

Supported by : 부산대학교병원

References

  1. Soto Araya, M., Rojas Aleayaga, G. & Esguep, A. Association between psychological disorders and the presence of Oral lichen planus, Burning mouth syndrome and Recurrent aphthous stomatitis. Med Oral 2004;9:1-7. https://doi.org/10.3353/omp.9.1
  2. 정현숙, 강규숙, 황애란. 정신 사회적 스트레스와 스트 레스질환. 대한간호 1988;26(5):25-28.
  3. 백기청, 홍강의. 스트레스 요인으로서의 생활사건과 통재소재 빛 불안의 관계에 대한 연구. 신경정신의학회지 1987;78(1):75-77.
  4. Stein S, Hart DL, Loft G, Davis H. Symptoms of TMJ dysfunction or related to stress measured by the social readjustment rating scale. J Prosthet Dent 1982;47:545-546. https://doi.org/10.1016/0022-3913(82)90307-9
  5. Jurge S, Kuffer R, Scully C, Porter SR. Mucosal disease series. Number VI. Recurrent aphthous stomatitis. Oral Dis 2006;12(1):1-21.
  6. Ship JA, Chavez EM, Doerr PA, Henson BS, Sarmadi M. Recurrent aphthous stomatitis. Quintessence Int 2000;31(2):95-112.
  7. Bagan JV, Sanchis JM, Milan MA, Penarrocha M, Silvestre FJ. Recurrent aphthous stomatitis: a study of the clinical characteristics of lesions in 93 cases. J Oral Patho Med 1991;20(8):395-397. https://doi.org/10.1111/j.1600-0714.1991.tb00952.x
  8. Thornhill MH, Baccaglini L, Theaker E, Pemberton MN. A randomized, double-blind, placebo-controlled trial of pentoxifylline for the treatment of recurrent aphthous stomatitis. Arch Dermatol 2007;143(4): 460-470.
  9. Zunt SL. Recurrent aphthous stomatitis. Dermatol Clin 2003;21:33-39.
  10. Al-Omiri MK, Karasneh J, Linch E. Psychological profiles in patients with recurrent aphthous ulcers Int J Oral Maxillofac Surg 2012;41:384-388. https://doi.org/10.1016/j.ijom.2011.12.024
  11. Albanidou-Farmaki E, Poulopoulos AK, Epivatianos A, Farmakis K, Karamouzis M, Antoniades D. Increased anxiety level and high salivary and serum cortisol concentrations in patients with recurrent aphthous stomatitis. Tohoku J Exp Med 2008;214: 291-296. https://doi.org/10.1620/tjem.214.291
  12. McCartan BE, Lamey P-J, Wallace AM. Salivary cortisol and anxiety in recurrent aphthous stomatitis. J Oral Pathol Med 1996;25:357-359. https://doi.org/10.1111/j.1600-0714.1996.tb00278.x
  13. Redwine L, Snow S, Mills P, Irwin M. Acute psychological stress: effects on chemotaxis and cellular adhesion molecule expression. Psychosom Med 2003;65:598-603. https://doi.org/10.1097/01.PSY.0000079377.86193.A8
  14. Scully C, Gorsky M, Lozada-Nur F. The diagnosis and management of recurrent aphthous stomatitis: a consensus approach. J Am Dent Assoc 2003;134:200-207. https://doi.org/10.14219/jada.archive.2003.0134
  15. Gallo Cde B, Mimura MA, Sugaya NN. Psychological stress and recurrent aphthous stomatitis. Clinics 2009;64:645-648.
  16. Andrews VH, Hall HR. The effects of relaxation/ imagery training on recurrent aphthous stomatitis: a preliminary study. Psychosom Med 1990;52:526-535. https://doi.org/10.1097/00006842-199009000-00005
  17. Pedersen A. Psychologic stress and recurrent aphthous ulceration. J Oral Pathol Med 1989;18: 119-122. https://doi.org/10.1111/j.1600-0714.1989.tb00747.x
  18. Sherman JJ, Barach R, Whitcomb KK, Haley J, Martin MD. Pain and pain-related interference associated with recurrent aphthous ulcers. J Orofac Pain 2007;21:99-106.
  19. Heft M, Wray D. Anxiety levels in recurrent aphthous stomatitis (RAS) patients. J Dent Res 1982:61:264.
  20. Ferguson MM, Carter J, Boyle P. An epidemiological study of factors associated with recurrent aphthae in women. J Oral Pathol Med 1984;39:212-217.
  21. Holmes TH, Rahe RH,. The social readjustment rating scale. J Psychosom. Res 1967;11:213-217. https://doi.org/10.1016/0022-3999(67)90010-4
  22. 백기청, 홍강의. 스트레스 요인으로서의 생활사건과 통재소재 빛 불안의 관계에 대한 연구. 신경정신의학회지 1987;78(1):75-77.
  23. Wyler AR, Masuda M, Holmes T.H. Magnitude of life events and serious of illness. Psychosom Med 1967;33:115-117.
  24. 고병학, 송옥헌, 신윤오. 한국인의 생활사건에 관한 예비적 연구. 신경정신의학회지 1981;20(1):62-63.
  25. 최태진, 강병조. 한국에서의 사회 재적응평가척도에 관한 예비적 연구. 신경정신의학회지 1981;55(2):131-132.
  26. 홍강의, 정도언. 사회 재적응평가척도 제작. 신경정신의학회지 1982;21(1):123-135.
  27. 이평숙. 생활사건과 관련된 스트레스양 측정에 관한 방법론적 연구. 연세대학교 박사학위논문집 1984;1-138.
  28. 조대경, 이관용, 김기중. 정신위생, 초판, 서울, 1984, 중앙적성출판부, pp.75-101.
  29. 이승우 외. 측두하악장애의 진단과 치료. 초판, 서울, 1986, 고문사, pp.9-22, 111-137.
  30. 박준상, 고명연. SRRS를 이용한 측두하악장애 환자의 생활변화에 관한 연구. 구강내과학회지 1987;12:63-74.
  31. Barrons RW. Treatment strategies for recurrent oral aphthous ulcers. Am J Health Syst Pharm 2001;58: 41-50.