DOI QR코드

DOI QR Code

Apoptosis in Cancer - An Update

  • Sankari, S. Leena ;
  • Masthan, K.M.K. ;
  • Babu, N. Aravindha ;
  • Bhattacharjee, Tathagata ;
  • Elumalai, M.
  • 발행 : 2012.10.31

초록

Apoptosis is programmed cell death which is essential for development and survival of living organisms. It is a sequentially regulated suicidal programme where cells activate certain enzymes which dissolute their own nuclear component and various protein component of nucleus and cytoplasm. Disturbance of this regulatory pathway may lead to various diseases like autoimmune diseases, neurodegenerative diseases and cancers. The potential mechanisms of apoptosis and its role in cancer are discussed. The ability of apoptosis to modulate the life or death of a cell is also recognized for its immense therapeutic potential. Understanding the mechanisms from this review will give us better insight to the pathogenesis of various diseases including cancer and will open new horizons to therapeutic approaches.

키워드

Apoptosis;caspases;cancer;detection

참고문헌

  1. Abou-Nassar K, Brown JR (2010). Novel agents for the treatment of chronic lymphocytic leukaemia. Clin Adv Haematol Oncol, 8, 886-95.
  2. Apoptosis Detection Guide (2010). Enzo Life Sciences Inc. International edition. pp1-14.
  3. Ataur Rahman, Tipu Sultan, Rokibul Islam (2012). Apoptosis and cancer: insights molecular mechanisms and treatments. Int J Biomol and Biomed, 2,1-16.
  4. Boeckler FM, Joerger AC, Jaggi G, et al (2008). Targeted rescue of a destabilised mutant of p53 by an in silico screened drug. Proc Natl Acad Sci USA, 105, 10360-5. https://doi.org/10.1073/pnas.0805326105
  5. Cheung H-H, Liu X, Rennert OM (2012). Apoptosis: Reprogramming and the fate of mature cells, ISRN Cell Biology, 2012, 1-8.
  6. Curtin JF, Cotter TG (2003). Apoptosis: historical perspectives. Essays Biochem, 39, 1-10.
  7. Deveraux QL, Takahashi R, Salvesen GS, et al (1997). X-linked IAP is a direct inhibitor of cell-death proteases. Nature, 388, 300-4. https://doi.org/10.1038/40901
  8. Dai Y, Lawrence TS, Xu L (2009). Overcoming cancer therapy resistance by targeting inhibitors of apoptosis proteins and nuclear factor-kappa B. Am J Tranl Res, 1, 1-15.
  9. Dewson G, Kluc RM,(2010) Bcl-2 family-regulated apoptosis in health and disease. Cell Hlth and Cytoskeleton, 2, 9-22.
  10. Elmore S (2007). Apoptosis: a review of programmed cell death. Toxicol Pathol, 35, 495-516. https://doi.org/10.1080/01926230701320337
  11. Gewies A (2003). Apo Review - Introduction to Apoptosis: pp1-26
  12. Hanahan D, Weinberg RA (2000). The hallmarks of cancer. Cell, 100, 57-70. https://doi.org/10.1016/S0092-8674(00)81683-9
  13. Hassen S, Ali N, Chowdhury P (2012) Molecular signaling mechanisms of apoptosis in hereditary non-polyposis colorectal cancer. World J Gastrointest Pathophysiol, 3, 7-79. https://doi.org/10.4239/wjd.v3.i1.7
  14. Horvitz HR (1999). Genetic control of programmed cell death in the nematode Caenorhabditis elegans. Cancer Res, 59, 1701-6.
  15. Holdenrieder S, Stieber P (2004). The potential of apoptotic markers in diagnostic oncology: as featured in CLI December 2004.
  16. Imawati B, Holt O, Michael L, et al (1999). Biochemical pathways of caspase activation during apoptosis annu. Rev Cell Dev Biol, 15, 269-90. https://doi.org/10.1146/annurev.cellbio.15.1.269
  17. Kerr JF, Wyllie AH, Currie AR (1972). Apoptosis: a basic, biological phenomenon with wide ranging implications, in tissue kinetics. Br J Cancer, 26, 239-57. https://doi.org/10.1038/bjc.1972.33
  18. Krejci P, Pejchalova K, Rosenbloom BE, et al (2007). The antiapoptotic protein Api5, and its partner, high molecular weight FGF2, are up-regulated in B cell chronic lymphoid leukemia. J Leukoc Bio, 82, 1363-4. https://doi.org/10.1189/jlb.0607425
  19. Masthan KMK, AravindhaBabu N, Kailash CD, et al (2012) Advanced diagnostic aids in oral cancer. Asian Pac J Cancer Prev, 13, 1-4. https://doi.org/10.7314/APJCP.2012.13.8.3573
  20. Morris EJ, Michaud WA, Ji JY, et al (2006). Functional identification of Api5 as a suppressor of E2Fdependent apoptosis in vivo. PLoS Genetics, 2, 196. https://doi.org/10.1371/journal.pgen.0020196
  21. Quinn L, Deveraux, John C Reed (1999). IAP family proteins-suppressors of apoptosis. Genes Dev, 13, 239-52. https://doi.org/10.1101/gad.13.3.239
  22. Rai KR, Moore J, Wu J, et al (2008). Effect of the addition of oblimersen (Bcl-2 antisense) to fludarabine/cyclophosphamide for replased/refractory chronic lymphocytic leukaemia (CLL) on survival in patients who achieve CR/nPR: Five-year follow-up from a randomized phase III study. J Clin Oncol, 26, 7008.
  23. Ramirez CR, Carracedo AJ, Moreno Aguilary FC, et al (1999). Apoptosis and disease. Alergol Inmunol Clin, 14, 367-4.
  24. Rebecca SY Wong (2011). Apoptosis in cancer: from pathogenesis to treatment. J Exp Clin Cancer Res, 30, 1-14. https://doi.org/10.1186/1756-9966-30-1
  25. Roy N, Deveraux QL, Takahashi R, et al (1997). The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. EMBOJ, 16, 6914-25. https://doi.org/10.1093/emboj/16.23.6914
  26. Rigou P,Piddubnyak V,Faye A et al (2009). The antiapoptotic protein AAC-11 interacts with and regulates Acinusmediated DNA fragmentation: The EMBO Journal, 28, 1576-88. https://doi.org/10.1038/emboj.2009.106
  27. Sasaki H, Moriyama S, Yukiue H, et al (2001). Expression of theantiapoptosis gene, AAC-11, as a prognosis marker in non-small cell lung cancer. Lung Cancer, 34, 53-7.
  28. Schroder M, Kaufman RJ (2005). The mammalian unfolded protein response. Annu Rev Biochem, 74, 739-89. https://doi.org/10.1146/annurev.biochem.73.011303.074134
  29. Searle J, Kerr JFR, Bishop CJ (1982). Necrosis and apoptosis: distinct modes of cell death with fundamentally different significance. Pathol Annu, 17, 229-59.
  30. Seshagiri S, Miller LK (1997). Baculovirus inhibitors of apoptosis (IAPs) block activation of Sf-caspase-1. Proc Natl Acad Sci USA, 94, 13606-11. https://doi.org/10.1073/pnas.94.25.13606
  31. Szegezdi E, Fitzgerald U, Samali A (2003). Caspase-12 and ER-stress-mediated apoptosis: the story so far. Ann NY Acad Sci, 1010, 186-94. https://doi.org/10.1196/annals.1299.032
  32. Szegezdi E, Logue SE, Gorman AM, et al (2006). Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep, 7, 880-5. https://doi.org/10.1038/sj.embor.7400779
  33. Tewari M, Yu M, Ross B, et al (1997). AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal. Cancer Res, 57, 4063-9.
  34. Tiwari.(2012) Journal of Cancer Therapeutics and Research, pp1 -10)http://www.hoajonline.com/journals/jctr/content/pdf/3.pdf.
  35. Van den Berghe L, Laurell H, Huez I et al (2000). FIF [fibroblast growth factor-2 (FGF-2)-interacting-factor],a nuclear putatively antiapoptotic factor, interacts specifically with FGF-2. Mol Endocrinol (Baltimore, Md), 14, 1709-24. https://doi.org/10.1210/me.14.11.1709
  36. World Health Organization (2010). Cancers the problem, NMH Fact sheet January.
  37. Zinszner H, Kuroda M, Wang X, et al (1998). CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes Dev, 12, 982-95 https://doi.org/10.1101/gad.12.7.982

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