- Volume 13 Issue 9
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Anal Cancer Screening by Modified Liquid-Based Cytology in an HIV Clinic
- Patarapadungkit, Natcha (Department of Pathology, Faculty of Medicine, Khon Kaen University) ;
- Koonmee, Supinda (Department of Pathology, Faculty of Medicine, Khon Kaen University) ;
- Pasatung, Emorn (Department of Pathology, Faculty of Medicine, Khon Kaen University) ;
- Pisuttimarn, Pornrith (Department of Medicine, Faculty of Medicine, Khon Kaen University) ;
- Mootsikapun, Piroon (Department of Medicine, Faculty of Medicine, Khon Kaen University)
- Published : 2012.09.30
This study aimed to screen for anal cancer and to determine its cytomorphology using liquid-based cytology (LBC) with specimens preserved in 95% ethyl alcohol. Anal swabs were collected for cytological examination from 177 adult, HIV-infected patients. After collection, sample slides were reviewed and classified according to their cytomorphology using the modified Bethesda 2001 system. An abnormal anal Pap smear was found in 26.0% of the patients. The diagnoses were: 66.7% negative for intraepithelial lesions (NIL), 14.1% with atypical squamous cells of undetermined significance (ASC-US), 10.7% (19) with low-grade squamous intraepithelial lesions (LSIL), and 1.13% with high-grade squamous intraepithelial lesions (HSIL). The cytological evaluation was an unsatisfactory result only with 6.67%. The present modified LBC using 95% ethyl alcohol as the preservative could thus be used for anal cancer screening. The number of SILs in Thai HIV-infected patients is lower than that in Western countries. We found anal cytology a satisfactory tool for early screening and detection of anal dysplasia commonly found in high-risk, HIV-infected patients.
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