- Volume 13 Issue 9
DOI QR Code
Lack of Association of Glutathione S-transferase M3 Gene Polymorphism with the Susceptibility of Lung Cancer
- Feng, Xu (Department of Cardio-Thoracic Surgery, The First Affiliated Hospital of Guangxi Medical University) ;
- Dong, Chun-Qiang (Department of Pediatric Surgery, The First Affiliated Hospital of Guangxi Medical University) ;
- Shi, Jun-Jie (Department of Cardio-Thoracic Surgery, The First Affiliated Hospital of Guangxi Medical University) ;
- Zhou, Hua-Fu (Department of Cardio-Thoracic Surgery, The First Affiliated Hospital of Guangxi Medical University) ;
- He, Wei (Department of Cardio-Thoracic Surgery, The First Affiliated Hospital of Guangxi Medical University) ;
- Zheng, Bao-Shi (Department of Cardio-Thoracic Surgery, The First Affiliated Hospital of Guangxi Medical University)
- Published : 2012.09.30
Objective: The conclusions of published reports on the relationship between the glutathione S-transferase M3 (GSTM3) A/B gene polymorphism and the risk of lung cancer are still debated. This meta-analysis was performed to evaluate the association between GSTM3 and the risk of lung cancer. Methods: Association investigations were identified from PubMed, Embase, and Cochrane Library, and eligible studies were included and synthesized using a meta-analysis method. Results: Eight reports were included into this meta-analysis for the association of GSTM3 A/B gene polymorphism and lung cancer susceptibility, covering 1,854 patients with lung cancer and 1,926 controls. No association between the GSTM3 A/B gene polymorphism and lung cancer was found in this meta-analysis (B allele: OR = 1.25, 95% CI: 0.89-1.76, P = 0.20; BB genotype: OR = 1.53, 95% CI: 0.71-3.32, P = 0.28; AA genotype: OR = 0.85, 95% CI: 0.59-1.23, P = 0.39). Conclusions: The GSTM3 A/B gene polymorphism is not associated with lung cancer susceptibility. However, more studies on the relationship between GSTM3 A/B gene polymorphism and the risk of lung cancer should be performed in the future.
- Begg CB, Mazumdar M (1994). Operating characteristics of a rank correlation test for publication bias. Biometrics, 50, 1088-101. https://doi.org/10.2307/2533446
- Dai L, Duan F, Wang P, et al (2012). XRCC1 gene polymorphisms and lung cancer susceptibility: a meta-analysis of 44 casecontrol studies. Mol Biol Rep, 39, 9535-47. https://doi.org/10.1007/s11033-012-1818-2
- Egger M, Davey SG, Schneider M, et al (1997). Bias in metaanalysis detected by a simple, graphical test. BMJ, 315, 629-34. https://doi.org/10.1136/bmj.315.7109.629
- Gong M, Dong W, An R (2012). Glutathione S-transferase T1 Polymorphism Contributes to Bladder Cancer Risk: A Meta- Analysis Involving 50 Studies. DNA Cell Biol, 31, 1187-97. https://doi.org/10.1089/dna.2011.1567
- Guan P, Huang D, Yin Z, et al (2011). Association of the hOGG1 Ser326Cys polymorphism with increased lung cancer susceptibility in Asians: a meta-analysis of 18 studies including 7592 cases and 8129 controls. Asian Pac J Cancer Prev, 12, 1067-72.
- Jourenkova-Mironova N, Wikman H, Bouchardy C, et al (1998). Role of glutathione S-transferase GSTM1, GSTM3, GSTP1 and GSTT1 genotypes in modulating susceptibility to smoking-related lung cancer. Pharmacogenetics, 8, 495-502. https://doi.org/10.1097/00008571-199812000-00006
- Kesarwani P, Singh R, Mittal RD (2009). Association of GSTM3 intron 6 variant with cigarette smoking, tobacco chewing and alcohol as modifier factors for prostate cancer risk. Arch Toxicol, 83, 351-6. https://doi.org/10.1007/s00204-008-0343-5
- Ladero JM, Martinez C, Fernandez JM, et al (2007). Glutathione S-transferases pi 1, alpha 1 and M3 genetic polymorphisms and the risk of hepatocellular carcinoma in humans. Pharmacogenomics, 8, 895-9. https://doi.org/10.2217/146224126.96.36.1995
- Liu F, He Y, Peng X, et al (2010). Association of the 8473T>C cyclooxygenase-2 (COX-2) gene polymorphism with lung cancer risk in Asians. Asian Pac J Cancer Prev, 11, 1257-62.
- Loft S, Svoboda P, Kasai H, et al (2007). Prospective study of urinary excretion of 7-methylguanine and the risk of lung cancer: Effect modification by mu class glutathione-Stransferases. Int J Cancer, 121, 1579-84. https://doi.org/10.1002/ijc.22863
- Lou J, Xue J, Lin Q (2011). Transcriptome-wide network analysis of squamous lung cancer reveals potential methylation genes. Asian Pac J Cancer Prev, 12, 2349-52.
- Malik MA, Upadhyay R, Mittal RD, et al (2010). Association of xenobiotic metabolizing enzymes genetic polymorphisms with esophageal cancer in Kashmir Valley and influence of environmental factors. Nutr Cancer, 62, 734-42. https://doi.org/10.1080/01635581003605904
- Reszka E, Wasowicz W, Gromadzinska J (2007). Antioxidant defense markers modulated by glutathione S-transferase genetic polymorphism: results of lung cancer case-control study. Genes Nutr, 2, 287-94. https://doi.org/10.1007/s12263-007-0057-y
- Risch A, Wikman H, Thiel S, et al (2001). Glutathione-Stransferase M1, M3, T1 and P1 polymorphisms and susceptibility to non-small-cell lung cancer subtypes and hamartomas. Pharmacogenetics, 11, 757-64. https://doi.org/10.1097/00008571-200112000-00003
- Saarikoski ST, Voho A, Reinikainen M, et al (1998). Combined effect of polymorphic GST genes on individual susceptibility to lung cancer. Int J Cancer, 77, 516-21. https://doi.org/10.1002/(SICI)1097-0215(19980812)77:4<516::AID-IJC7>3.0.CO;2-X
- Singh H, Sachan R, Devi S, et al (2008). Association of GSTM1, GSTT1, and GSTM3 gene polymorphisms and susceptibility to cervical cancer in a North Indian population. Am J Obstet Gynecol, 198, 303-6.
- Sorensen M, Autrup H, Tjonneland A, et al (2004). Glutathione S-transferase T1 null-genotype is associated with an increased risk of lung cancer. Int J Cancer, 110, 219-24. https://doi.org/10.1002/ijc.20075
- Tian T, Zhang E, Fei F, et al (2011). Up-regulation of GTSE1 lacks a relationship with clinical data in lung cancer. Asian Pac J Cancer Prev, 12, 2039-43.
- Tsai YY, McGlynn KA, Hu Y, et al (2003). Genetic susceptibility and dietary patterns in lung cancer. Lung Cancer-J Iaslc, 41, 269-81. https://doi.org/10.1016/S0169-5002(03)00238-1
- Wang JJ, Zheng Y, Sun L, et al (2011). TP53 codon 72 polymorphism and colorectal cancer susceptibility: a metaanalysis. Mol Biol Rep, 38, 4847-53. https://doi.org/10.1007/s11033-010-0619-8
- Ye Z, Song H, Higgins JP, et al (2006). Five glutathione s-transferase gene variants in 23,452 cases of lung cancer and 30,397 controls: meta-analysis of 130 studies. PLoS Med, 3, 91. https://doi.org/10.1371/journal.pmed.0030091
- Zienolddiny S, Campa D, Lind H, et al (2008). A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of non-small cell lung cancer in smokers. Carcinogenesis, 29, 1164-9. https://doi.org/10.1093/carcin/bgn020