- Volume 13 Issue 9
DOI QR Code
Meta-analysis of the Relation Between the VDR Gene TaqIpolymorphism and Genetic Susceptibility to Prostate Cancer in Asian Populations
- Guo, Ya-Jie (College of Materials and Chemistry & Chemical Engineering, Chengdu University of Technology) ;
- Shi, Ze-Ming (College of Materials and Chemistry & Chemical Engineering, Chengdu University of Technology) ;
- Liu, Jun-Da (College of Materials and Chemistry & Chemical Engineering, Chengdu University of Technology) ;
- Lei, Ning (College of Materials and Chemistry & Chemical Engineering, Chengdu University of Technology) ;
- Chen, Qiu-Hong (College of Materials and Chemistry & Chemical Engineering, Chengdu University of Technology) ;
- Tang, Ying (College of Materials and Chemistry & Chemical Engineering, Chengdu University of Technology)
- Published : 2012.09.30
Background: Polymorphisms of the Taq I gene have been associated with prostate cancer risk. Methods:We applied a fixed-effects model to combine odds ratios (ORs) and 95% confidence intervals (95% CI). The Egger's test was carried out to evaluate potential publication bias. Results: A total of 10 case-control studies enrolling 1,141 prostate cancer patients and 1,685 controls were included in this meta-analysis. Compared with the T allele, the OR for the C allele was 0.81 (0.70-0.94). The ORs for CT and CC+CT genotypes were 0.86 (0.74-1.01) and 0.84 (0.73-0.97) compared to wide type genotype (homozygote TT). Conclusions: The present meta-analysis suggests that the TF gene Taq I polymorphism may reduce the prostate cancer risk in Asian populations.
- Bao BY, Yeh SD, Lee YF (2006). 1alpha,25-dihydroxyvitamin D3 inhibits prostate cancer cell invasion via modulation of selective proteases.Carcinogenesis, 27, 32-42.
- Bai Y, Yu Y, Yu B, et al (2009). Association of vitamin D receptor polymorphisms with the risk of prostate cancer in the Han population of Southern China. BMC Med Genet, 10, 125.
- Bid HK, Mishra DK, Mittal RD (2005). Vitamin-D receptor (VDR) gene (Fok-I, Taq-I and Apa-I) polymorphisms in healthy individuals from north Indian population. Asian Pac J Cancer Pre, 6, 147-52.
- Campbell MJ, Elstner E, Holden S, et al (1997). Inhibition of proliferation of prostate cancer cells by a 19-nor-hexafluoride vitamin D3 analogue involves the induction of p21waf1, p27kip1 and Ecadherin. J Mol Endocrinol, 19, 15-27. https://doi.org/10.1677/jme.0.0190015
- Cariati F, Negri A, Pivonello C, et al (2012). Vitamin D from genetics to the clinical in prostate cancer. Endocrine Abstracts, 29, P836.
- Chaimuangraj S, Thammachoti R, Ongphiphadhanakul B, et al (2006). Lack of association of VDR polymorphisms with Thai prostate cancer as compared with benign prostate hyperplasia and controls. Asian Pac J Cancer Prev, 7, 136-9.
- Corder EH, Guess HA, Hulka BS et al (1993).Vitamin D and prostate cancer: a prediagnostic study with stored sera. Cancer Epidemiol Biomarkers Prev, 2, 467-72.
- Dersimonian R, Laird N (1986). Meta-analysis in clinical trials. Control Clin Trials, 7, 177-88. https://doi.org/10.1016/0197-2456(86)90046-2
- Habuchi T, Suzuki T, Sasaki R, et al (2000). Association of vitamin D receptor gene polymorphism with prostate cancer and benign prostatic hyperplasia in a Japanese population. Cancer Res, 60, 305-8.
- Hamasaki T, Inatomi H, Katoh T, et al (2001).Clinical and pathological significance of vitamin D receptor gene polymorphism for prostate cancer which is associated with a higher mortality in Japanese. Endocr J, 48, 543-9. https://doi.org/10.1507/endocrj.48.543
- Hamasaki T, Inatomi H, Katoh T, et al (2002). Significance of vitamin D receptor gene polymorphism for risk and disease severity of prostate cancer and benign prostatic hyperplasia in Japanese. Urol Int, 68, 226-31. https://doi.org/10.1159/000058440
- Hidalgo AA, Paredes R, Garcia VM, et al (2007). Altered VDRmediated transcriptional activity in prostate cancer stroma. J Steroid Biochem Mol Biol, 103, 731-6. https://doi.org/10.1016/j.jsbmb.2006.12.072
- Huang SP, Chou YH, Wayne Chang WS, et al (2004).Association between vitamin D receptor polymorphisms and prostate cancer risk in a Taiwanese population. Cancer Lett, 207, 69-77. https://doi.org/10.1016/j.canlet.2003.12.006
- Jemal A, Siegel R, Ward E, et al (2009). Cancer statistics, 2009. CA Cancer J Clin, 59, 225-49. https://doi.org/10.3322/caac.20006
- Jose S, George PS, Mathew A (2008). Assessment of confounding and interaction using the mantel-haenszel risk estimation method. Asian Pac J Cancer Prev, 9, 323-5.
- Krishnan AV, Peehl DM, Feldman D (2003). Inhibition of prostate cancer growth by vitamin D: Regulation of target gene expression. J Cell Biochem, 88, 363-71. https://doi.org/10.1002/jcb.10334
- Li M, Zhang S, Ma J, et al (2009). A comparative study on incidence trends of prostate cancer in part of cities and counties in China. Chin J Urol, 30, 368-70. (article in China)
- Liu J, Li H, Gu L, et al (2004a). Association between VDRG 3' polymorphisms and prostate cancer in Chinese population. Chin J Clin Rehab, 8, 3429-32. (article in China)
- Liu J, Li H, Tong M, et al (2004b). Susceptibility gene polymorphism and risk of prostate cancer in Chinese population. Nat Med J China, 84, 364-8. (article in China)
- Moon SJ, Fryer AA, Strange RC (2005). Ultraviolet radiation: effects on risks of prostate cancer and other internal cancers. Mutat Res, 571, 207-19. https://doi.org/10.1016/j.mrfmmm.2004.09.015
- Onsory K, Sobti RC, Al-Badran AI, et al (2008). Hormone receptor-related gene polymorphisms and prostate cancer risk in North Indian population.Mol Cell Biochem,314,25-35. https://doi.org/10.1007/s11010-008-9761-1
- Schaid DJ(2004).The complex genetic epidemiology of prostate cancer. Hum Mol Genet, 13, R103-21. https://doi.org/10.1093/hmg/ddh072
- Schwartz GG (2012). Circulating vitamin D and risk of prostate cancer--letter. Cancer Epidemiol Biomarkers Prev, 21, 246. https://doi.org/10.1158/1055-9965.EPI-11-0910
- Schwartz GG, Hulka BS (1990). Is vitamin D deficiency a risk factor for prostate cancer? (Hypothesis). Anticancer Res, 10, 1307-11.
- Suzuki K, Matsui H, Ohtake N, et al (2003).Vitamin D receptor gene polymorphism in familial prostate cancer in a Japanese population. Int J Urol, 10, 261-6. https://doi.org/10.1046/j.1442-2042.2003.00617.x
- Vieira AR (2006). Association between the transforming growth factor alpha gene and nonsyndromic oral clefts: a HuGE review. Am J Epidemiol, 163, 790-810. https://doi.org/10.1093/aje/kwj103
- Watanabe M, Fukutome K, Murata M, et al (1999).Significance of vitamin D receptor gene polymorphism for prostate cancer risk in Japanese. Anticancer Res, 19, 4511-4.
- Williamson PR, Gamble C, Altman DG, et al (2005). Outcome selection bias in meta-analysis. Stat Methods Med Res, 14, 515-24. https://doi.org/10.1191/0962280205sm415oa
- Ylikomi T, Laaksi I, Lou YR, et al (2002).Antiproliferative action of vitamin D. Vitam Horm, 64, 357-406. https://doi.org/10.1016/S0083-6729(02)64010-5
- Zhang WB, Zhang JH, Pan ZQ, et al (2012). The MTHFR C677T Polymorphism and Prostate Cancer Risk: New Findings from a Meta-analysis of 7306 Cases and 8062 Controls. Asian Pac J Cancer Prev, 13, 2597-604. https://doi.org/10.7314/APJCP.2012.13.6.2597
- Zmuda JM, Cauley JA, Ferrell RE (2000).Molecular epidemiology of vitamin D receptor gene variants. Epidemiol Rev, 22, 203-17. https://doi.org/10.1093/oxfordjournals.epirev.a018033
- Association of Benign Prostate Hyperplasia with Polymorphisms in VDR, CYP17, and SRD5A2 Genes among Lebanese Men vol.15, pp.3, 2014, https://doi.org/10.7314/APJCP.2014.15.3.1255
- An Integrated Approach to Defining Genetic and Environmental Determinants for Major Clinical Outcomes Involving Vitamin D vol.18, pp.3, 2014, https://doi.org/10.1007/s40291-014-0087-2
- Systematic review and meta-analysis on vitamin D receptor polymorphisms and cancer risk vol.35, pp.5, 2014, https://doi.org/10.1007/s13277-013-1544-y
- The Effects of Various Chemical Factors on Prostate Tumor Cells of Cx43 and the Significance of the Cancer Treatment vol.05, pp.01, 2015, https://doi.org/10.12677/WJCR.2015.51002