Survival of Patients with Lung Cancer, Yazd, Iran

  • Zahir, Shokouh Taghipour (Shokouh Taghipour zahir, Asssociate professor of clinical and surgical pathology, shahid sadoughi university of medical sciences) ;
  • Mirtalebi, Maryammosadate (Maryammosadate Mirtalebi, Resident in pathology, Isfahan university of medical sciences)
  • Published : 2012.09.30


Background: Lung carcinoma is the leading cause of cancer mortality worldwide. Although the 5-year survival rate nearly tripled from 5-15% over the last 25 years, the estimated number of deaths still exceeds 1.3 million annually. The overall 5-year survival of lung cancer is only 10% in Europe and 15% in the United States. The aim of the current study was to determine the long-term survival and the effect of certain prognostic factors on survival of patients with lung cancer in Yazd city, Iran. Methods: In this cross-sectional descriptive study, we retrospectively reviewed hospital records and follow-up data of 148 patients with histological proven lung cancer using the cancer data registered between 1998 and 2005 in the pathology department of Shahid Sadoughi educational hospital, Yazd, Iran. Data were extracted from patient documents that included sex, age, clinical manifestations, histopathological report of the tumor and type of treatment given. Results: Overall survival time in all patients was 8.5 months after diagnosis and there was no significant difference in survival according to sex (p=0.958). Histological analysis revealed that squamous cell carcinoma was the most common histologic type (35%). Kaplan-Meier statistical methods estimated the average survival time for SCC to be better (22.6 months) in comparison with the other types of histology (all of them below 10 months). There was a trend towards significance between type of histology and duration of survival (p=0.08). Conclusion: It is reasonable to expect that early lung cancer detection, and appropriated treatment, may improve surgical morbidity and mortality. Low survival of lung cancer in our center patients show our shortages in screening programs for early diagnosis. Designing studies with larger sample size that take some other variables like staging of patients is now necessary.


  1. Kasper DL (2007). Cecil Essentials of Medicine/7th edition.W.B.Saunders, 1234.
  2. Arrieta O, Núñez-Valencia C, Reynoso-Erazo L, et al (2012). Health-related quality of life in patients with lung cancer: validation of the mexican-spanish version and association with prognosis of the EORTC QLQ-LC13 questionnaire. Lung Cancer, 77, 205-11.
  3. Armandas-Gil L, Vaque-Rafart J, Rossello J, et al (1999). cigarette smoking and male lung cancer risk with special regard to type of tobacco, Int J Epidemiol, 28, 614-19.
  4. Battafarano RJ, Piccirillo JF, Meyers BF, et al (2002). Impact of comorbidity on survival after surgical resection in patients with stage I non-small cell lung cancer. J Thorac Cardiovasc Surg, 123, 280-7.
  5. Bepler G (1999). Lung Cancer Epidemiology and Genetics. J Thorac Imaging, 14, 228-34.
  6. Berghmans T, Paesmans M, Meert AP, et al (2005). Survival improvement in resectable non-small cell lung cancer with (neo)adjuvant chemotherapy: results of a meta-analysis of the literature. Lung Cancer, 49,13-23.
  7. Berrino F, Capocaccia R, Estève J, et al (1999). survival of cancer patients in europe: the eurocare-2 study. iarc scientific publications no. 151. Lyon, International Agency for Research on Cancer, 1-572.
  8. Boffetta P, Ahrens W, Nyberg F, et al (1999), exposure to envirnomental tobacco smoke and risk of adenocarcinoma of the lung, Int J Cancer, 83, 635-39.<635::AID-IJC12>3.0.CO;2-E
  9. Charloux A, Quoix E, Wolkove N, et al (1997). the increasing incidence of lung adenocarcinoma: reality or artefact? a review of theepidemiology of lung adenocarcinoma. Int J Epidemiol, 26, 14-23.
  10. Choi NC, Mathisen DJ, Huberman MS et al (1990). cancer manual. (osteen rt), 8 th ed. Am Cancer Society, Massachusetts Division, 188-201.
  11. Cristiano LM (1997), Public health concerns about lung cancer. Chest, 112, 214-5.
  12. Droste JH, Weyler JJ, Van Meerbeeck JP, et al (1999), occupational risk factors of lung cancer: a hospital based case-control study. Occup Environ Med, 56, 322-7.
  13. Eberhardt WE, Stamatis G, Stuschke M (2009). Surgery in stage III non-small-cell lung cancer. Lancet,374, 359-60.
  14. Ehteshamifar A, Mousavi SAJ, Aram N, et al (2001). Prevalence of different histopathologic types of lung cancer in patients of tehran city hospitals during 1992-1999. Razi Medical journal. 26, 373-81.
  15. Ernester VE, Mustacchi P, Osann KE (1994). textbook of respiratory medicine. (murray jf), 2 nd edition. W.B. Saunders Company, 1485-1631.
  16. Fraser RS, Pare JAP, Fraser RG (1994). Synopsis of diseases of the chest. second edition. W.B. Saunders Company, 445-539.
  17. Gilbert S, Zhang H, Villeneuve PJ, et al (2012). Optimizing health care resource utilization in the surgical management of patients with suspected lung cancer. Ann Thorac Surg.
  18. Greenberg M (1999), A study of lung cancer mortality in asbestosis workers: doll, Am J Ind Med, 36, 331-47.<331::AID-AJIM1>3.0.CO;2-3
  19. Haraguchi S, Koizumi K, Mikami I, et al (2011), Clinicopathological characteristics and prognosis of nonsmall cell lung cancer patients associated with a family history of lung cancer. Int J Med Sci, 9, 68-73.
  20. Honnorat J, Antoine JC (2007). "Paraneoplastic neurological syndromes". orphanet journal of rare diseases (BioMed Central), 2, 22.
  21. Horn L, Pao W, Johnson DH (2012). "89". Harrison's principles of internal medicine (18th ed.), McGraw-Hill.
  22. Jahn I, Ahrens W, Bruske-hohlfeld I, et al (1999). Occupational risk factors for lung cancer in women results of a case-control study in Germany, Am J Ind Med, 36, 90-100.<90::AID-AJIM13>3.0.CO;2-V
  23. Kawaguchi T, Takada M, Kubo A, et al (2010). Gender, histology, and time of diagnosis are important factors for prognosis: analysis of 1499 never-smokers with advanced non-small cell lung cancer in Japan.J Thorac Oncol, 5, 1011-17.
  24. Kefeli U, Kaya S, Ustaalioglu BO, et al (2011). Prognostic factors in elderly patients with non-small cell lung cancer: a two-center experience. Med Oncol, 28, 661-6.
  25. Lee IM, Sesso HD,Paffenbarger RS (1999). Physical activity and risk of lung cancer. Int J Epidemiol, 28, 620-25.
  26. Leonard CT, Sachs DP (1999). Environmental tobacco smoke and lung cancer incidence. Curr Opin Pulm Med, 5, 189-93.
  27. Linder J (2000). Lung cancer cytology. something old, something new. Am J Clin Pathol, 114, 169-71.
  28. Marra A, Richardsen G, Wagner W, et al (2011). Prognostic factors of resected node-positive lung cancer: location, extent of nodal metastases, and multimodal treatment. Thorac Surg Sci, 8, 1.
  29. Mayne ST, Buenconsejo J, janerich dt (1999). previous lung disease and risk of lung cancer among men and women nonsmoker, Am J Epidemiol, 149, 13-20.
  30. Misciasci T (2004). Noninvasive staging of lung cancer. Rays, 29, 363-71.
  31. Morinaga K, Nakamura K, Kohyama N, et al (1999). A retrospective cohort study of male workers exposed to pva fibers. Ind Health, 37, 18-21.
  32. Najafi F, Jafari R, Mozaffari HR et al (2010). Incidance of lung cancer in kermanshah province. Behbood (journal of Kermanshah University of Medical Sciences), 14,342-48.
  33. Pellegrini S, Bertacca G, Buttitta F, et al (1999). Lung tumors from non-smoking subjects: a p53- related genetic instability in subset of cases, Int J Mol Med, 4, 419-24.
  34. Pezzotto SM, Poletto L (1999). Occupation and histopathology of lung cancer: a case-control study in rosario, Argentina. Am J Ind Med, 36, 437-43.<437::AID-AJIM4>3.0.CO;2-C
  35. Prescott E, Gronbaek M, Becker U, et al (1999). Alcohol intake and the risk of lung cancer: influence of type of alcoholic beverage. Am J Epidemiol, 149, 463-70.
  36. Postmus PE (2005). Bronchoscopy for lung cancer. Chest, 128, 16-18.
  37. Puri V, Garg N, Engelhardt EE, Kreisel D, et al (2010). Tumor location is not an independent prognostic factor in early stage non-small cell lung cancer. Ann Thorac Surg, 89, 1053-9.
  38. Rapiti E, Jindal SK, Gupta D, et al (1999). Passive smoking and lung cancer in chandigarh, India, Lung Cancer, 23, 183-89.
  39. Read WL, Page NC, Tierney RM, et al (2004). The epidemiology of bronchioloalveolar carcinoma over the past two decades: analysis of the SEER database. Lung Cancer, 45, 137-42.
  40. Ronneberg A, Haldorsen T, Romunstad P, et al (1999). Occupational exposure and cancer incidence among workers from an aluminum smelter in western norway, Scand J Work Environ Health, 25, 207-17.
  41. Santoro IL, Ramos RP, Franceschini J, et al (2011). Non-small cell lung cancer in never smokers: a clinical entity to beidentified. Clinics (Sao Paulo), 66, 1873-7.
  42. Schneider J (2006). Tumor markers in detection of lung cancer. Adv Clin Chem, 42, 1-41.
  43. Speizer FE, Colditz GA, Hunter DJ, et al (1999), intake, and lung cancer in middle-aged women (USA). Cancer Causes Control, 10, 475-82.
  44. Strauss CM (1997), Women and lung cancer. Chest, 112, 229- 234.
  45. Wakai K, Ohno Y, Genka K, et al (1999). Risk modification in lung cancer by a dietary intake of preserved foods and soyfoods: finding from a case-control study in okinava, Japan. Lung Cancer, 25, 147-59.
  46. WHO Histological Typing of lung cancers (1981), 2nd ed. Geneva/London.
  47. Zhou B, Wang T, Sun G, et al (1999). A case- control study of relationship between dietary factors and risk of lung cancer in women of shenyang, China. Oncol Rep, 6, 139-43.

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