- Volume 13 Issue 8
DOI QR Code
Association of Poor Prognosis Subtypes of Breast Cancer with Estrogen Receptor Alpha Methylation in Iranian Women
- Izadi, Pantea (Department of Medical Genetics, Medical School, Tehran University of Medical Sciences) ;
- Noruzinia, Mehrdad (Department of Medical Genetics, School of Medical Sciences, Tarbiat Modares University) ;
- Fereidooni, Foruzandeh (Pathology Department, Cancer Institute, Tehran University of Medical Sciences) ;
- Nateghi, Mohammad Reza (Iranian Biological Resources Center(IBRC), ACECR)
- Published : 2012.08.31
Breast cancer is a prevalent heterogeneous malignant disease. Gene expression profiling by DNA microarray can classify breast tumors into five different molecular subtypes: luminal A, luminal B, HER-2, basal and normal-like which have differing prognosis. Recently it has been shown that immunohistochemistry (IHC) markers including estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (Her2), can divide tumors to main subtypes: luminal A (ER+; PR+/-; HER-2-), luminal B (ER+;PR+/-; HER-2+), basal-like (ER-;PR-;HER2-) and Her2+ (ER-; PR-; HER-2+). Some subtypes such as basal-like subtype have been characterized by poor prognosis and reduced overall survival. Due to the importance of the ER signaling pathway in mammary cell proliferation; it appears that epigenetic changes in the
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