- Volume 13 Issue 8
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MTHFR C677T Polymorphism and Ovarian Cancer Risk: A Meta-analysis
- Ding, Xiao-Ping (Department of Obstetrics and Gynecology, the Second Artillery General Hospital) ;
- Feng, Li (Department of Obstetrics and Gynecology, the Second Artillery General Hospital) ;
- Ma, Li (Department of Obstetrics and Gynecology, the Second Artillery General Hospital)
- Published : 2012.08.31
Background: Many studies have investigated possible association between the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and ovarian cancer risk, but the impact is still unclear owing to the obvious inconsistencies. This study was performed to quantify the strength of the association with a metaanalysis. Methods: We searched the PubMed, Embase, and CNKI databases for studies relating the association between MTHFR C677T polymorphism and ovarian cancer risk and estimated summary odds ratios (ORs) with confidence intervals (CIs) for assessment. Results: Finally, eight studies with a total of 3,379 ovarian cancer cases and 4,078 controls were included into this meta-analysis. Overall the showed that MTHFR C677T polymorphism was not associated with ovarian cancer risk under all genetic models (
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