Prognostic Significance of HER-2/neu and Survival of Breast Cancer Patients Attending a Specialized Breast Clinic in Kolkata, Eastern India

  • Jana, Debarshi (Breast Cancer Research Unit, Breast Service) ;
  • Mandal, Syamsundar (Department of Epidemiology and Biostatistics, Chittaranjan National Cancer Institute) ;
  • Mukhopadhyay, Madhumita (Department of Pathology, Institute of Post Graduate Medical Education & Research (IPGME&R) and Seth Sukhlal Karnani Memorial Hospital (SSKM)) ;
  • Mitra, Debabrata (Department of Radiotherapy, Medical College) ;
  • Mukhopadhyay, Sunit K. (Department of Veterinary Pathology, West Bengal University of Animal and Fishery Sciences) ;
  • Sarkar, Diptendra Kumar (Department of Surgery, Institute of Post Graduate Medical Education & Research (IPGME&R) and Seth Sukhlal Karnani Memorial Hospital (SSKM))
  • 발행 : 2012.08.31


Introduction: The worldwide incidence of breast cancer has increased rapidly in recent years. The scenario of Eastern India is also showing the same trend. It is necessary to study the utility of HER-2/neu as a prognostic factor in breast cancer survival. However, there have not been detailed studies in this respect with the breast cancer patients of Eastern India. Thus this study was conducted. Materials and Methods: In this hospital-based study 86 breast cancer patients attending a breast clinic of a reputed institute of Eastern India and having invasive ductal carcinomas were observed for a period of 5 years after surgery. Associations between 5 years observed survival and status of ER, PR and HER-2/neu of the patients were critically evaluated. Results: There was statistically significant association between survival pattern for 5 years and the HER-2/neu status (p=0.00001). Better survival was observed for the patients with HER-2/neu negative tumors 67(100%) compared to HER-2/neu positive tumors 7(36.8%). Conclusions: There is strong interaction between survival and HER-2/neu expression of breast cancer patients. Thus the patients with HER-2/neu positive tumors need to be treated aggressively.


Breast cancer;prognosis;HER-2/neu;survival;follow-up;Eastern India


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