- Volume 13 Issue 8
DOI QR Code
Association Between the GSTP1 Codon 105 Polymorphism and Gastric Cancer Risk: an Updated Meta-analysis
- Bao, Li-Dao (Department of Pharmacy, Affiliated Hospital of Inner Mongolia Medical University) ;
- Niu, Jian-Xiang (Department of General Surgery Affiliated Hospital of Inner Mongolia Medical University) ;
- Song, Hui (Department of Medicine of Jinan Central Hospital, and Medical School of Shandong University) ;
- Wang, Yi (Department of Pharmacy, Affiliated Hospital of Inner Mongolia Medical University) ;
- Ma, Rui-Lian (Department of Pharmacy, Affiliated Hospital of Inner Mongolia Medical University) ;
- Ren, Xian-Hua (Department of Pharmacy, Affiliated Hospital of Inner Mongolia Medical University) ;
- Wu, Xin-Lin (Department of General Surgery Affiliated Hospital of Inner Mongolia Medical University)
- Published : 2012.08.31
Objective: The current meta-analysis was performed to address a more accurate estimation of the association between glutathione S-transferase P1 (GSTP1) codon 105 polymorphism and risk of gastric cancer (GC), which has been widely reported with conflicting results. Methods: A comprehensive literature search was conducted to identify all the relevant studies. Fixed or random effect models were selected based on the heterogeneity test. Publication bias was estimated using Begg's funnel plots and Egger's regression test. Results: A total of 20 studies containing 2,821 GC cases and 6,240 controls were finally included in the analyses. Overall, no significant association between GSTP1 polymorphism and GC risk was observed in worldwide populations. However, subgroup analysis stratified by ethnicity showed that GSTP1 polymorphism was significantly associated with increased risk of GC in Asians (G vs. A, OR = 1.273, 95%CI=1.011-1.605; GG vs. AA, OR=2.103, 95%CI=1.197-3.387; GG vs. AA+AG, OR =2.103, 95%CI=1.186-3.414). In contrast, no significant association was found in Caucasians in any genetic models, except for with AG vs. AA (OR=0.791, 95%CI=0.669-0.936). Furthermore, the GSTP1 polymorphism was found to be significantly associated with GC in patients with H. pylori infection and in those with a cardiac GC. Subgroup analysis stratified by Lauren's classification and smoking status showed no significant association with any genetic model. No studies were found to significantly influence the pooled effects in each genetic mode, and no potential publication bias was detected. Conclusion: This meta-analysis suggested that the GSTP1 polymorphism might be associated with increased risk of GC in Asians, while GSTP1 heterozygote genotype seemed to be associated with reduced risk of GC. Since potential confounders could not be ruled out completely, further studies are needed to confirm these results.
- Ali-Osman F, Akande O, Antoun G, Mao JX, Buolamwini J (1997). Molecular cloning, characterization, and expression in Escherichia coli of full-length cDNAs of three human glutathione S-transferase Pi gene variants. Evidence for differential catalytic activity of the encoded proteins. J Biol Chem, 272, 10004-12. https://doi.org/10.1074/jbc.272.15.10004
- Alves C, Silva F, Gusmao L, et al (2000). Extended structural variation of a pentanucleotide repeat in the GSTP1 gene: characterisation in a normal population and in thyroid and gastric tumours. Eur J Hum Genet, 8, 540-4. https://doi.org/10.1038/sj.ejhg.5200486
- Brenner H, Rothenbacher D, Arndt V (2009). Epidemiology of stomach cancer. Meth Mol Biol, 2, 467-78.
- Catalano V, Graziano F (2011). Management of Advanced Gastric Cancer. Chemotherapy, ?, 28-43.
- Crew KD, Neugut AI (2006). Epidemiology of gastric cancer. World J Gastroenterol, 12, 354-62. https://doi.org/10.3748/wjg.v12.i3.354
- Deng SL, Yuan T, Chen M, et al (2011). Relationship between the polymorphism of GSTP1 and susceptibility to gastric cancer in southwest Chinese. China J Mod Med, 21, 73-4.
- Fuchs CS, Mayer RJ (1995). Gastric carcinoma. N Engl J Med, 333, 32-41. https://doi.org/10.1056/NEJM199507063330107
- Graham DY, Adam E, Reddy GT, et al (1991). Seroepidemiology ofHelicobacter pylori infection in India. Digestive Dis Sci, 36, 1084-8. https://doi.org/10.1007/BF01297451
- Harbord RM, Egger M, Sterne JA (2006). A modified test for small-study effects in meta-analyses of controlled trials with binary endpoints. Stat Med, 25, 3443-57. https://doi.org/10.1002/sim.2380
- Higgins JP, Thompson SG (2002). Quantifying heterogeneity in a meta-analysis. Stat Med, 21, 1539-58. https://doi.org/10.1002/sim.1186
- Hong SH, Kim JW, Kim HG., et al (2006). Glutathione S-transferases (GSTM1, GSTT1 and GSTP1) and N-acetyltransferase 2 polymorphisms and the risk of gastric cancer. J Prev Med Public Health, 39, 135-40.
- Humans IWGotEoCRt (1994). Schistosomes, Liver Flukes and Helicobacter pylori. Lyon, France.
- Jiang YL, Zhu XQ, Xu L (2011). Relationship between gastric cancer and glutathione S-transferase P1 gene polymorphism in the elderly. Chin J Geriatr, 30, 651-3.
- Johansson AS, Stenberg G, Widersten M, Mannervik B (1998). Structure-activity relationships and thermal stability of human glutathione transferase P1-1 governed by the H-site residue 1051. J Mol Biol, 278, 687-98. https://doi.org/10.1006/jmbi.1998.1708
- Kang JM, Kim N, Cho SI, et al (2008). Effects of Genetic Polymorphisms of Glutathione S-transferase P1 on Helicobacter pylori-associated Gastric Cancer. Gut Liver, 2, 23-9. https://doi.org/10.5009/gnl.2008.2.1.23
- Katoh T, Kaneko S, Takasawa S, et al (1999). Human glutathione S-transferase P1 polymorphism and susceptibility to smoking related epithelial cancer; oral, lung, gastric, colorectal and urothelial cancer. Pharmacogenetics, 9, 165-9.
- Ketterer B (1988). Protective role of glutathione and glutathione transferases in mutagenesis and carcinogenesis. Mutat Res, 202, 343-61. https://doi.org/10.1016/0027-5107(88)90197-2
- Lan Q, Chow WH, Lissowska J, et al (2001). Glutathione S-transferase genotypes and stomach cancer in a population-based case-control study in Warsaw, Poland. Pharmacogenetics, 11, 655-61. https://doi.org/10.1097/00008571-200111000-00003
- Lau J, Antman EM, Jimenez-Silva J, et al (1992). Cumulative meta-analysis of therapeutic trials for myocardial infarction. N Engl J Med, 327, 248-54. https://doi.org/10.1056/NEJM199207233270406
- Malik MA, Upadhyay R, Mittal RD, et al (2009). Role of xenobiotic-metabolizing enzyme gene polymorphisms and interactions with environmental factors in susceptibility to gastric cancer in Kashmir Valley. J Gastrointest Cancer, 40, 26-32. https://doi.org/10.1007/s12029-009-9072-0
- Martinez C, Martin F, Fernandez JM, et al (2006). Glutathione S-transferases mu 1, theta 1, pi 1, alpha 1 and mu 3 genetic polymorphisms and the risk of colorectal and gastric cancers in humans. Pharmacogenomics, 7, 711-8. https://doi.org/10.2217/146224188.8.131.521
- Mu LN, Lu QY, Yu SZ, et al (2005). Green tea drinking and multigenetic index on the risk of stomach cancer in a Chinese population. Int J Cancer, 116, 972-83. https://doi.org/10.1002/ijc.21137
- Neugut AI, Hayek M, Howe G (1996). Epidemiology of gastric cancer. Semin Oncol, 23, 281-91.
- Nguyen TV, Janssen MJ, van Oijen MG, et al (2010). Genetic polymorphisms in GSTA1, GSTP1, GSTT1, and GSTM1 and gastric cancer risk in a Vietnamese population. Oncol Res, 18, 349-55. https://doi.org/10.3727/096504010X12626118080064
- Parsonnet J, Friedman G, Orentreich N, Vogelman H (1997). Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection. Gut, 40, 297-301. https://doi.org/10.1136/gut.40.3.297
- Rebbeck TR (1997). Molecular epidemiology of the human glutathione S-transferase genotypes GSTM1 and GSTT1 in cancer susceptibility. Cancer Epidemiol Biomarkers Prev, 6, 733-43.
- Roth MJ, Abnet CC, Johnson LL, et al (2004). Polymorphic variation of Cyp1A1 is associated with the risk of gastric cardia cancer: a prospective case-cohort study of cytochrome P-450 1A1 and GST enzymes. Cancer Causes Control, 15, 1077-83. https://doi.org/10.1007/s10552-004-2233-3
- Ruzzo A, Canestrari E, Maltese P, et al (2007). Polymorphisms in genes involved in DNA repair and metabolism of xenobiotics in individual susceptibility to sporadic diffuse gastric cancer. Clin Chem Lab Med, 45, 822-8.
- Setiawan VW, Zhang ZF, Yu GP, et al (2001).GSTP1 polymorphisms and gastric cancer in a high-risk Chinese population. Cancer Causes Control, 12, 673-81. https://doi.org/10.1023/A:1011261602940
- Singh K, Ghoshal UC (2006).Causal role of Helicobacter pylori infection in gastric cancer: an Asian enigma. World J Gastroenterol, 12, 1346-51. https://doi.org/10.3748/wjg.v12.i9.1346
- Tamer L, Ates NA, Ates C, et al (2005).Glutathione S-transferase M1, T1 and P1 genetic polymorphisms, cigarette smoking and gastric cancer risk. Cell Biochem Funct, 23, 267-72. https://doi.org/10.1002/cbf.1148
- Tobias A (1999). Assessing the influence of a single study in the meta-analysis estimate. Stata Tech Bull, 7, 15-7.
- Tripathi S, Ghoshal U, Ghoshal UC, et al (2008). Gastric carcinogenesis: Possible role of polymorphisms of GSTM1, GSTT1, and GSTP1 genes. Scand J Gastroenterol, 43, 431-9. https://doi.org/10.1080/00365520701742930
- Tripathi S, Ghoshal U, Mittal B, et al (2011). Association between gastric mucosal glutathione-S-transferase activity, glutathione-S-transferase gene polymorphisms and Helicobacter pylori infection in gastric cancer. Indian J Gastroenterol, 30, 257-63. https://doi.org/10.1007/s12664-011-0144-2
- Wideroff L, Vaughan TL, Farin FM, et al (2007). GST, NAT1, CYP1A1 polymorphisms and risk of esophageal and gastric adenocarcinomas. Cancer Detect Prev, 31, 233-6. https://doi.org/10.1016/j.cdp.2007.03.004
- Yadav DS, Devi TR, Ihsan R, et al (2010). Polymorphisms of glutathione-S -transferase genes and the risk of aerodigestive tract cancers in the Northeast Indian population. Genet Test Mol Biomarkers, 14, 715-23. https://doi.org/10.1089/gtmb.2010.0087
- Zendehdel K, Bahmanyar S, McCarthy S, et al (2009). Genetic polymorphisms of glutathione S-transferase genes GSTP1, GSTM1, and GSTT1 and risk of esophageal and gastric cardia cancers. Cancer Causes Control, 20, 2031-8. https://doi.org/10.1007/s10552-009-9399-7
- Zhang A, Liu B, Wang L, et al (2011). Glutathione S-transferase Gene Polymorphisms and Risk of Gastric Cancer in a Chinese Population. Asian Pac J Cancer Prev, 12, 3421-5.
- Zhang Y, Sun LP, Chen W, et al (2007). A molecular epidemiological study on the relationship between the polymorphism of GSTP1 and susceptibility to gastric cancer in northern Chinese. Yi Chuan, 29, 293-300. https://doi.org/10.1360/yc-007-0299
- Zhou Y, Li N, Zhuang W, et al (2009). Glutathione S-transferase P1 gene polymorphism associated with gastric cancer among Caucasians. Eur J Cancer, 45, 1438-42. https://doi.org/10.1016/j.ejca.2008.12.020
- Association of DNA repair and xenobiotic pathway gene polymorphisms with genetic susceptibility to gastric cancer patients in West Bengal, India vol.37, pp.7, 2016, https://doi.org/10.1007/s13277-015-4780-5
- Relationship between epithelial cell adhesion molecule (EpCAM) overexpression and gastric cancer patients: A systematic review and meta-analysis vol.12, pp.4, 2017, https://doi.org/10.1371/journal.pone.0175357