- Volume 13 Issue 8
DOI QR Code
XRCC1 Arg399Gln Gene Polymorphism and Hepatocellular Carcinoma Risk in the Chinese Han Population: A Meta-analysis
- Duan, Wei-Hong (Institute of Hepatobiliary and Gastrointestinal Disease, Erpao General Hospital) ;
- Zhu, Zhen-Yu (Institute of Hepatobiliary and Gastrointestinal Disease, Erpao General Hospital) ;
- Liu, Jun-Gui (Institute of Hepatobiliary and Gastrointestinal Disease, Erpao General Hospital) ;
- Dong, Mao-Sheng (Institute of Hepatobiliary and Gastrointestinal Disease, Erpao General Hospital) ;
- Chen, Jun-Zhou (Institute of Hepatobiliary and Gastrointestinal Disease, Erpao General Hospital) ;
- Liu, Quan-Dda (Institute of Hepatobiliary and Gastrointestinal Disease, Erpao General Hospital) ;
- Xie, Yu (Institute of Hepatobiliary and Gastrointestinal Disease, Erpao General Hospital) ;
- Sun, Ti-Ye (Institute of Hepatobiliary and Gastrointestinal Disease, Erpao General Hospital) ;
- Gao, Ze-Feng (Shanxi Province Tumor Hospital) ;
- Zhou, Ning-Xin (Institute of Hepatobiliary and Gastrointestinal Disease, Erpao General Hospital)
- Published : 2012.08.31
Purpose: Numerous studies have evaluated the association between XRCC1 Arg399Gln gene polymorphism and hepatocellular carcinoma risk in the Chinese Han population. However, the results have been inconsistent. We therefore here examined whether the XRCC1 Arg399Gln gene polymorphism confers hepatocellular carcinoma risk by conducting a meta-analysis. Methods: PubMed, Google scholar and China National Knowledge Infrastructure databases were searched for eligible articles in English and Chinese that were published before April 2012. Results: 6 studies involving 1,246 patients with hepatocellular carcinoma and 1,953 controls were included. The association between XRCC1 Arg399Gln gene polymorphism and hepatocellular carcinoma in the Chinese Han population was significant under GG vs AA (OR = 1.48, 95% CI = 1.13 to 1.94). Limiting the analysis to the studies with controls in the Hardy-Weinberg equilibrium, the results were persistent and robust. Conclusions: In the Chinese Han population, the XRCC1 Arg399Gln gene polymorphism is associated with an increased hepatocellular carcinoma risk.
- Chen CC, Yang SY, Liu CJ, et al (2005). Association of cytokine and DNA repair gene polymorphisms with hepatitis Brelated hepatocellular carcinoma. Int J Epidemiol, 34, 1310-8. https://doi.org/10.1093/ije/dyi191
- Cui Z, Yin Z, Li X, et al (2012). Association between polymorphisms in XRCC1 gene and clinical outcomes of patients with lung cancer: a meta-analysis. BMC Cancer, 12, 71. https://doi.org/10.1186/1471-2407-12-71
- Dufloth RM, Costa S, Schmitt F, et al (2005). DNA repair gene polymorphisms and susceptibility to familial breast cancer in a group of patients from Campinas, Brazil. Genet Mol Res, 30, 771-82.
- Ferlay J, Shin HR, Bray F, et al (2010). Estimates of worldwide burden of cancer in 2008: GLOBOCAN. Int J Cancer, 127, 2893-917. https://doi.org/10.1002/ijc.25516
- Forner A, Llovet JM, Bruix J (2012). Hepatocellular carcinoma. Lancet, 379, 1245-55. https://doi.org/10.1016/S0140-6736(11)61347-0
- Geng J, Zhang YW, Huang GC, et al (2008). XRCC1 genetic polymorphism Arg399Gln and gastric cancer risk: A metaanalysis. World J Gastroenterol, 14, 6733-7. https://doi.org/10.3748/wjg.14.6733
- Higgins JP, Thompson SG (2002). Quantifying heterogeneity in a meta-analysis. Stat Med, 21, 1539-58. https://doi.org/10.1002/sim.1186
- Kirk GD, Turner PC, Gong Y, et al (2005). Hepatocellular carcinoma and polymorphisms in carcinogen-metabolizing and DNA repair enzymes in a population with aflatoxin exposure and hepatitisBvirus endemicity. Cancer Epidemiol Biomarkers Prev, 14, 373-9. https://doi.org/10.1158/1055-9965.EPI-04-0161
- Lindahl T, Wood RD (1999). Wood.Quality control by DNA repair. Science, 286, 1897-905. https://doi.org/10.1126/science.286.5446.1897
- Liu Y, Chen H, Chen L, et al (2012). Prediction of genetic polymorphisms of DNA repair genes XRCC1 and XRCC3 in the survival of colorectal cancer receiving chemotherapy in the Chinese population. Hepatogastroenterology, 59, 977-80.
- Long XD, Ma Y, Wei YP, et al (2005). X-ray repair crosscomplementing group 1(XRCC1) Arg 399 GIn polymorphism and aflatoxin B1(AFB1)-related hepatocellular carcinoma(HCG) in Guangxi population. Chin J Cancer Res, 17, 17-21. https://doi.org/10.1007/s11670-005-0004-7
- Long XD, Ma Y, Wei YP, et al (2006). The polymorphisms of GSTM1, GSTT1, HYL1_2, and XRCC1, and aflatoxin B1- related hepatocellular carcinoma in Guangxi population, China. Hepatol Res, 36, 48-55. https://doi.org/10.1016/j.hepres.2006.06.004
- Ren Y, Wang DS, Li Z, et al (2008). Study on the relationship between Gene XRCC1 Codon 399 S ingle Nucleotide Polymorphisms and Primary Hepatic Carcinoma in Han Nationality. Chin J Clin Hepatol, 24, 361-4 (article in Chinese).
- Shen MR, Jones IM, Mohrenweiser H (1998). Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans. Cancer Res, 58, 604-8.
- Tang YT, Li XP, Liu TQ, et al (2011). Genetic poIymorphisms of DNA repair genes in patients with hepatocellular carcinoma. J Shandong Med, 51,19-20 (article in Chinese).
- Tahara T, Shibata T, Nakamura M, et al (2009). Effect of polymorphisms in the 3' untranslated region (3'- UTR) of vascular endothelial growth factor gene on gastric cancer and peptic ulcer diseases in Japan. Mol Carcinog, 48, 1030-7. https://doi.org/10.1002/mc.20554
- Thompson LH, West MG (2000). XRCC1 keeps DNA from getting stranded. Mutat Res, 459, 1-18. https://doi.org/10.1016/S0921-8777(99)00058-0
- Wang Y, Spitz MR, Zhu Y, et al (2003). From genotype to phenotype: correlating XRCC1 polymorphisms with mutagen sensitivity. DNA Repair (Amst), 2, 901-8. https://doi.org/10.1016/S1568-7864(03)00085-5
- Wu K, Su D, Lin K, et al (2011). XRCC1 Arg399Gln gene polymorphism and breast cancer risk: a meta-analysis based on case-control studies. Asian Pac J Cancer Prev, 12, 2237-43.
- Yang JL, Han YN, Zheng SG (2004). Influence of human XRCC1-399 single nucleotide polymorphism on primary hepatocytic carcinoma. Zhong Liu, 24, 322-4 (article in Chinese).
- Yu HP, Zhang XY, Wang XL, et al (2004). DNA repair gene XRCC1 polymorphisms,smoking, and esophageal cancer risk. Cancer Detect Prev, 28, 194-9. https://doi.org/10.1016/j.cdp.2004.01.004
- Yu MW, Yang SY, Pan IJ, et al (2003). Polymorphisms in XRCC1 and glutathione S-transferase genes and hepatitis B-related hepatocellular carcinoma. J Natl Cancer Inst, 95, 1485-8. https://doi.org/10.1093/jnci/djg051
- Zintzaras E, Loannidis JP (2005). Heterogeneity testing in metaanalysis of genome searches. Genet. Epidemiol, 28, 123-37. https://doi.org/10.1002/gepi.20048
- The XRCC1 Arg399Gln Gene Polymorphism and Risk of Colorectal Cancer: a Study in Kashmir vol.14, pp.11, 2013, https://doi.org/10.7314/APJCP.2013.14.11.6779
- Association between the XRCC1 Arg399Gln Polymorphism and Risk of Cancer: Evidence from 297 Case–Control Studies vol.8, pp.10, 2013, https://doi.org/10.1371/journal.pone.0078071
- Genetic polymorphisms of XRCC1 gene and susceptibility to hepatocellular carcinoma in Chinese population vol.31, pp.4, 2014, https://doi.org/10.1007/s12032-014-0887-6
- XRCC1 Arg399Gln genetic polymorphism and the risk of hepatocellular carcinoma: a meta-analysis vol.41, pp.2, 2014, https://doi.org/10.1007/s11033-013-2929-0
- Updated Assessment of the Association of the XRCC1 Arg399Gln Polymorphism with Lung Cancer Risk in the Chinese Population vol.16, pp.2, 2015, https://doi.org/10.7314/APJCP.2015.16.2.495