Update of Research on Drug Resistance in Small Cell Lung Cancer Chemotherapy

  • Chen, Yi-Tian (Department of Medical Oncology, Jinling Hospital) ;
  • Feng, Bing (Department of Medical Oncology, Jinling Hospital) ;
  • Chen, Long-Bang (Department of Medical Oncology, Jinling Hospital)
  • Published : 2012.08.31


Small cell lung cancer (SCLC) is characterized by a short cell doubling time, rapid progression and early occurrence of blood-borne and lymph metastasis. The malignancy is the highest of all lung cancer types. Although SCLC has a relatively good initial response to chemotherapy as well as radiotherapy, relapse or disease progression may occur quickly after the initial treatment. Drug resistance, especially multi-drug resistance, is the most important cause of failure of SCLC chemotherapy. This article provides a brief update of research on mechanisms of drug resistance in SCLC and reversal strategies.


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