- Volume 24 Issue 12
DOI QR Code
Effect of Corticosterone on Hypothalamic Corticotropin-releasing Hormone Expression in Broiler Chicks (Gallus gallus domesticus) Fed a High Energy Diet
- Song, Zhigang (College of Animal Science and Technology, Shandong Agricultural University) ;
- Yuan, Lei (College of Animal Science and Technology, Shandong Agricultural University) ;
- Jiao, Hongchao (College of Animal Science and Technology, Shandong Agricultural University) ;
- Lin, Hai (College of Animal Science and Technology, Shandong Agricultural University)
- Received : 2011.06.03
- Accepted : 2011.08.09
- Published : 2011.12.01
This paper reports the peripheral and central effect of corticosterone on feed intake and hypothalamic corticotropinreleasing hormone (CRH) gene expression in chicks fed a high energy diet. Three experiments were conducted: corticosterone was supplemented to the feed (30 mg/kg diet), injected subcutaneously (s.c., 4 mg/kg body weight) or intracerebroventricularly (i.c.v., 4 ng). The results showed that dietary corticosterone significantly increased feed intake. The s.c. corticosterone administration increased feed intake within 1 to 3 h and at 1 to 5 h after the injection. The i.c.v. corticosterone administration increased feed intake within 1 h after the injection, but not at 1 to 3 h. Dietary supplementation and s.c. injection of corticosterone decreased the CRH gene expression in the hypothalamus. Therefore, peripheral corticosterone exerted a decreased effect on hypothalamic CRH mRNA levels, and corticosterone had a stimulating effect on feed intake in broiler chicks fed a high energy diet.
Broiler Chicks;Corticosterone;Corticotropin-releasing Hormone;Feed Intake
- Antoni, F. A. 1986. Hypothalamic control of adrenocorticotropin secretion: advances since the discovery of 41-residue corticotropin-releasing factor. Endocr. Rev. 7:351-378. https://doi.org/10.1210/edrv-7-4-351
- Bell, M. E., S. Bhatnagar, J. Liang, L. Soriano, T. R. Nagy and M. F. Dallman. 2000. Voluntary sucrose ingestion, like corticosterone replacement, prevents the metabolic deficits of adrenalectomy. J. Neuroendocrinol. 12:461-470.
- Cai, Y., Z. Song, X. Zhang, X. Wang, H. Jiao and H. Lin. 2009. Increased de novo lipogenesis in liver contributes to the augmented fat deposition in dexamethasone exposed broiler chickens (Gallus gallus domesticus). Comp. Biochem. Physiol. C Toxicol. Pharmacol. 150:164-169. https://doi.org/10.1016/j.cbpc.2009.04.005
- Covasa, M. and J. M. Forbes. 1995. Selection of foods by broiler chickens following corticosterone administration. Br. Poult. Sci. 36:489-501. https://doi.org/10.1080/00071669508417794
- Dallman, M. F., S. F. Akana, A. M. Strack, K. S. Scribner, N. Pecoraro, S. E. La Fleur, H. Houshyar and F. Gomez. 2004. Chronic stress-induced effects of corticosterone on brain: direct and indirect. Ann. NY. Acad. Sci. 1018:141-150. https://doi.org/10.1196/annals.1296.017
- Dallman, M. F., J. P. Warne, M. T. Foster and N. C. Pecoraro. 2007. Glucocorticoids and insulin both modulate caloric intake through actions on the brain. J. Physiol. 583:431-436. https://doi.org/10.1113/jphysiol.2007.136051
- Denbow, D. M., N. Snapir and M. Furuse. 1999. Inhibition of food intake by CRF in chickens. Physiol. Behav. 66:645-649. https://doi.org/10.1016/S0031-9384(98)00340-0
- Davis, J. L., D. T. Masuoka, J. F. Gerbrandt and A. Cherkin 1979. Autoradiographic distribution of L-proline in chicks after intracerebral injection. Physiol. Behav. 22:693-699. https://doi.org/10.1016/0031-9384(79)90233-6
- Dong, H., H. Lin, H.C. Jiao, Z. G. Song, J. P. Zhao and K. J. Jiang. 2007. Altered development and protein metabolism in skeletal muscles of broiler chickens (Gallus gallus domesticus) by corticosterone. Comp. Biochem. Physiol. A Mol. Integr. Physiol. 147:189-195. https://doi.org/10.1016/j.cbpa.2006.12.034
- Epel, E., S. Jimenez, K. Brownell, L. Stroud, C. Stoney and R. Niaura. 2004. Are stress eaters at risk for the metabolic syndrome? Ann. NY. Acad. Sci. 1032:208-210. https://doi.org/10.1196/annals.1314.022
- Gross, K. L. and J. A. Cidlowski. 2008. Tissue-specific glucocorticoid action: a family affair. Trends Endocrinol. Metab. 9:331-339.
- Kretz, O., H. M. Reichardt, G. Schutz and R. Bock. 1999. Corticotropin releasing hormone expression is the major target for glucocorticoid feedback-control at the hypothalamic level. Brain Res. 818:488-491. https://doi.org/10.1016/S0006-8993(98)01277-3
- Laugero, K. D., F. Gomez, S. Manalo and M. F. Dallman. 2002. Corticosterone infused intracerebroventricularly inhibits energy storage and stimulates the hypothalamo-pituitary axis in adrenalectomized rats drinking sucrose. Endocrinology 143:4552-4562. https://doi.org/10.1210/en.2002-220613
- Lin, H., E. Decuypere and J. Buyse. 2004. Oxidative stress induced by corticosterone administration in broiler chickens (Gallus gallus domesticus): 2. Short-term effect. Comp. Physiol. B Biochem. Mol. Biol. 139:745-751. https://doi.org/10.1016/j.cbpc.2004.09.014
- Lin, H., S. J. Sui, H. C. Jiao, J. Buyse and E. Decuypere. 2006. Impaired development of broiler chickens by stress mimicked by corticosterone exposure. Comp. Biochem. Physiol. A Mol. Integr. Physiol. 143:400-405. https://doi.org/10.1016/j.cbpa.2005.12.030
- Livak, K. J. and T. D. Schmittgen. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C (T)) method. Methods 25:402-408. https://doi.org/10.1006/meth.2001.1262
- Malheiros, R. D., V. M. Moraes, A. Collin, E. Decuypere and J. Buyse. 2003. Free diet selection by broilers as influenced by dietary macronutrient ratio and corticosterone supplementation. 1. Diet selection, organ weights, and plasma metabolites. Poult. Sci. 82:123-131. https://doi.org/10.1093/ps/82.1.123
- Mantha, L., E. Palacios and Y. Deshaies. 1999. Modulation of triglyceride metabolism by glucocorticoids in diet-induced obesity. Am. J. Physiol. 277:R455-R464.
- Obici, S. and L. Rossetti. 2003. Minireview: nutrient sensing and the regulation of insulin action and energy balance. Endocrinology 144:5172-5178. https://doi.org/10.1210/en.2003-0999
- Pecoraro, N., F. Reye, F. Gomez, A. Bhargava and M. F. Dallman. 2004. Chronic stress promotes palatable feeding, which reduces signs of stress: feed forward and feedback effects of chronic stress. Endocrinology 145:3754-3762. https://doi.org/10.1210/en.2004-0305
- Plotsky, P. M. and P. E. Sawchenko. 1987. Hypophysial-portal plasma levels, median eminence content, and immunohistochemical staining of corticotropin-releasing factor, arginine vasopressin, and oxytocin after pharmacological adrenalectomy. Endocrinology 120:1361-1369. https://doi.org/10.1210/endo-120-4-1361
- Remage-Healey, L. and L. M. Romero. 2001. Corticosterone and insulin interact to regulate glucose and triglyceride levels during stress in a bird. Am. J. Physiol. Regul. Integr. Comp. Physiol. 281:R994-R1003.
- Richards, M. P. 2003. Genetic regulation of feed intake and energy balance in poultry. Poult. Sci. 82:907-916. https://doi.org/10.1093/ps/82.6.907
- Richard, D. 1993. Involvement of corticotropin-releasing factor in the control of food intake and energy expenditure. Ann. NY. Acad. Sci. 697:155-172. https://doi.org/10.1111/j.1749-6632.1993.tb49930.x
- Sainsbury, A., D. Wilks and G. J. Cooney. 2001. Central but not peripheral glucocorticoid infusion in adrenalectomized male rats increases basal and substrate-induced insulinemia through a parasympathetic pathway. Obes. Res. 9:274-281. https://doi.org/10.1038/oby.2001.33
- Sato, T., M. Sato, J. Shinsako and M. F. Dallman. 1975. Corticosterone induced changes in hypothalamic corticotropin-releasing factor (CRF) content after stress. Endocrinology 97:265-274. https://doi.org/10.1210/endo-97-2-265
- Simon, J., P. Freychet and G. Rosselin. 1974. Chicken insulin: radioimmunological characterization and enhanced activity in rat fat cells and liver plasma membranes. Endocrinology 95:1439-1449. https://doi.org/10.1210/endo-95-5-1439
- Stubbs, M. and D. A. York. 1991. Central glucocorticoid regulation of parasympathetic drive to pancreatic B-cells in the obese fa/fa rat. Int. J. Obes. 15:547-553.
- Tanimura, S. M. and A. G. Watts. 1998. Corticosterone can facilitate as well as inhibit corticotropin-releasing hormone gene expression in the rat hypothalamic paraventricular nucleus. Endocrinology 139:3830-3836. https://doi.org/10.1210/en.139.9.3830
- Tannenbaum, B. M., D. N. Brindley, G. S. Tannenbaum, M. F. Dallman, M. D. McArthur and M. J. Meaney. 1997. High-fat feeding alters both basal and stress-induced hypothalamic-pituitary-adrenal activity in the rat. Am. J. Physiol. 273:E1168- E1177.
- Vandenborne, K., B. De Groef, S. M. Geelissen, E. R. Kühn, V. M. Darras and S. Van der Geyten. 2005. Corticosterone-induced negative feedback mechanisms within the hypothalamo-pituitary-adrenal axis of the chicken. J. Endocrinol. 185:383-391. https://doi.org/10.1677/joe.1.05969
- Yuan, L., H. Lin, K. J. Jiang, H. C. Jiao and Z. G. Song. 2008. Corticosterone administration and high-energy feed results in enhanced fat accumulation and insulin resistance in broiler chickens. Br. Poult. Sci. 49:487-495. https://doi.org/10.1080/00071660802251731
- Zakrzewska, K. E., I. Cusin, A. Stricker-Krongrad, O. Boss, D. Ricquier, B. Jeanrenaud and F. Rohner-Jeanrenaud. 1999. Induction of obesity and hyperleptinemia by central glucocorticoid infusion in the rat. Diabetes 48:365-70. https://doi.org/10.2337/diabetes.48.2.365
- Forsythia suspensa extract attenuates corticosterone-induced growth inhibition, oxidative injury, and immune depression in broilers vol.93, pp.7, 2014, https://doi.org/10.3382/ps.2013-03772
- Effect of dexamethasone on hypothalamic expression of appetite-related genes in chickens under different diet and feeding conditions vol.7, pp.1, 2016, https://doi.org/10.1186/s40104-016-0084-x
- Comprehensive growth performance, immune function, plasma biochemistry, gene expressions and cell death morphology responses to a daily corticosterone injection course in broiler chickens vol.12, pp.2, 2017, https://doi.org/10.1371/journal.pone.0172684