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Demographic and lifestyle factors and selenium levels in men and women in the U.S.

  • Park, Kyong ;
  • Rimm, Eric ;
  • Siscovick, David ;
  • Spiegelman, Donna ;
  • Morris, J. Steven ;
  • Mozaffarian, Dariush
  • Received : 2011.05.18
  • Accepted : 2011.06.22
  • Published : 2011.08.31

Abstract

Selenium is an antioxidant trace element linked to cardiovascular disease and cancer. Although diet is a major source, relatively little else is known about independent determinants of selenium levels in free-living humans. In this study, we aimed to investigate the independent demographic. lifestyle, and dietary determinants of selenium levels in 1,997 men and 1,905 women in two large prospective U.S. cohorts. Toenail selenium levels were quantified using neutron activation analysis. Diet, geographic residence, demographic, and environmental factors were assessed by validated self-administered questionnaires. Multivariate generalized linear models were conducted to assess the independent relations of these factors with toenail selenium levels, correcting for measurement error in the diet. In multi variable-adjusted analyses, independent predictors of higher selenium were male gender (6.3% higher levels); living in West and Northern-Midwest U.S. regions (8.9% and 7.4% higher than Southern-Midwest regions, respectively); consumption of beef and bread products (between 0.7 - 2.5% higher per daily serving); and selenium supplement use (6.9% higher than non-users); whereas cigarette smoking (5-10% lower than never smokers), older age (0.6% lower per 5 years), and consumption of eggs, white rice, dairy products, coffee, and alcohol (between 0.1 to 2.0% lower per daily serving) were associated with lower selenium. Multiple dietary and non-dietary factors independently predicted selenium levels, suggesting that both consumption and non-dietary processes (e.g.. related to oxidant status) may affect levels. Significant geographic variation in selenium levels exists in the US.

Keywords

Selenium;toenail;determinants

References

  1. Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG. Selenium: biochemical role as a component of glutathione peroxidase. Science 1973;179:588-90. https://doi.org/10.1126/science.179.4073.588
  2. Chu FF, Doroshow JH, Esworthy RS. Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI. J Biol Chem 1993;268:2571-6.
  3. Hunter DJ, Morris JS, Chute CG, Kushner E, Colditz GA, Stampfer MJ, Speizer FE, Willett WC. Predictors of selenium concentration in human toenails. Am J Epidemiol 1990;132:114-22. https://doi.org/10.1093/oxfordjournals.aje.a115623
  4. Arnaud J, Bertrais S, Roussel AM, Arnault N, Ruffieux D, Favier A, Berthelin S, Estaquio C, Galan P, Czernichow S, Hercberg S. Serum selenium determinants in French adults: the SU.VI.M.AX study. Br J Nutr 2006;95:313-20. https://doi.org/10.1079/BJN20051528
  5. van den Brandt PA, Goldbohm RA, van't Veer P, Bode P, Hermus RJ, Sturmans F. Predictors of toenail selenium levels in men and women. Cancer Epidemiol Biomarkers Prev 1993;2:107-12.
  6. Swanson CA, Longnecker MP, Veillon C, Howe M, Levander OA, Taylor PR, McAdam PA, Brown CC, Stampfer MJ, Willett WC. Selenium intake, age, gender, and smoking in relation to indices of selenium status of adults residing in a seleniferous area. Am J Clin Nutr 1990;52:858-62. https://doi.org/10.1093/ajcn/52.5.858
  7. Satia JA, King IB, Morris JS, Stratton K, White E. Toenail and plasma levels as biomarkers of selenium exposure. Ann Epidemiol 2006;16:53-8. https://doi.org/10.1016/j.annepidem.2005.02.011
  8. Longnecker MP, Stampfer MJ, Morris JS, Spate V, Baskett C, Mason M, Willett WC. A 1-y trial of the effect of high-selenium bread on selenium concentrations in blood and toenails. Am J Clin Nutr 1993;57:408-13. https://doi.org/10.1093/ajcn/57.3.408
  9. Longnecker MP, Stram DO, Taylor PR, Levander OA, Howe M, Veillon C, McAdam PA, Patterson KY, Holden JM, Morris JS, Swanson CA, Willett WC. Use of selenium concentration in whole blood, serum, toenails, or urine as a surrogate measure of selenium intake. Epidemiology 1996;7:384-90. https://doi.org/10.1097/00001648-199607000-00008
  10. Foster LH, Sumar S. Selenium in health and disease: a review. Crit Rev Food Sci Nutr 1997;37:211-28. https://doi.org/10.1080/10408399709527773
  11. Mayne ST. Antioxidant nutrients and chronic disease: use of biomarkers of exposure and oxidative stress status in epidemiologic research. J Nutr 2003;133:933S-940S. https://doi.org/10.1093/jn/133.3.933S
  12. Ghayour-Mobarhan M, Taylor A, New SA, Lamb DJ, Ferns GA. Determinants of serum copper, zinc and selenium in healthy subjects. Ann Clin Biochem 2005;42:364-75. https://doi.org/10.1258/0004563054889990
  13. Hu FB, Bronner L, Willett WC, Stampfer MJ, Rexrode KM, Albert CM, Hunter D, Manson JE. Fish and omega-3 fatty acid intake and risk of coronary heart disease in women. JAMA 2002;287:1815-21. https://doi.org/10.1001/jama.287.14.1815
  14. Mozaffarian D, Ascherio A, Hu FB, Stampfer MJ, Willett WC, Siscovick DS, Rimm EB. Interplay between different polyunsaturated fatty acids and risk of coronary heart disease in men. Circulation 2005;111:157-64. https://doi.org/10.1161/01.CIR.0000152099.87287.83
  15. Garland M, Morris JS, Rosner BA, Stampfer MJ, Spate VL, Baskett CJ, Willett WC, Hunter DJ. Toenail trace element levels as biomarkers: reproducibility over a 6-year period. Cancer Epidemiol Biomarkers Prev 1993;2:493-7.
  16. MacIntosh DL, Williams PL, Hunter DJ, Sampson LA, Morris SC, Willett WC, Rimm EB. Evaluation of a food frequency questionnaire-food composition approach for estimating dietary intake of inorganic arsenic and methylmercury. Cancer Epidemiol Biomarkers Prev 1997;6:1043-50.
  17. Joshi A, Douglass CW, Kim HD, Joshipura KJ, Park MC, Rimm EB, Carino MJ, Garcia RI, Morris JS, Willett WC. The relationship between amalgam restorations and mercury levels in male dentists and nondental health professionals. J Public Health Dent 2003;63:52-60. https://doi.org/10.1111/j.1752-7325.2003.tb03474.x
  18. Morris JS, Stampfer MJ, Willett W. Dietary selenium in humans toenails as an indicator. Biol Trace Elem Res 1983;5:529-37. https://doi.org/10.1007/BF02988944
  19. Rosner B, Hennekens CH, Kass EH, Miall WE. Age-specific correlation analysis of longitudinal blood pressure data. Am J Epidemiol 1977;106:306-13. https://doi.org/10.1093/oxfordjournals.aje.a112466
  20. Rimm EB, Stampfer MJ, Colditz GA, Chute CG, Litin LB, Willett WC. Validity of self-reported waist and hip circumferences in men and women. Epidemiology 1990;1:466-73. https://doi.org/10.1097/00001648-199011000-00009
  21. Hu FB, Stampfer MJ, Colditz GA, Ascherio A, Rexrode KM, Willett WC, Manson JE. Physical activity and risk of stroke in women. JAMA 2000;283:2961-7. https://doi.org/10.1001/jama.283.22.2961
  22. Feskanich D, Rimm EB, Giovannucci EL, Colditz GA, Stampfer MJ, Litin LB, Willett WC. Reproducibility and validity of food intake measurements from a semiquantitative food frequency questionnaire. J Am Diet Assoc 1993;93:790-6. https://doi.org/10.1016/0002-8223(93)91754-E
  23. Salvini S, Hunter DJ, Sampson L, Stampfer MJ, Colditz GA, Rosner B, Willett WC. Food-based validation of a dietary questionnaire: the effects of week-to-week variation in food consumption. Int J Epidemiol 1989;18:858-67. https://doi.org/10.1093/ije/18.4.858
  24. Willett WC. Nutritional Epidemiology. 2nd ed. New York: Oxford University Press; 1998.
  25. Beaton GH, Milner J, Corey P, McGuire V, Cousins M, Stewart E, de Ramos M, Hewitt D, Grambsch PV, Kassim N, Little JA. Sources of variance in 24-hour dietary recall data: implications for nutrition study design and interpretation. Am J Clin Nutr 1979;32:2546-59. https://doi.org/10.1093/ajcn/32.12.2546
  26. Chimonas S, Rozario NM, Rothman DJ. Show us the money: lessons in transparency from state pharmaceutical marketing disclosure laws. Health Serv Res 2010;45:98-114. https://doi.org/10.1111/j.1475-6773.2009.01048.x
  27. Shi B, Spallholz JE. Bioavailability of selenium from raw and cooked ground beef assessed in selenium-deficient Fischer rats. J Am Coll Nutr 1994;13:95-101. https://doi.org/10.1080/07315724.1994.10718378
  28. Djujic IS, Jozanov-Stankov ON, Milovac M, Jankovic V, Djermanovic V. Bioavailability and possible benefits of wheat intake naturally enriched with selenium and its products. Biol Trace Elem Res 2000;77:273-85. https://doi.org/10.1385/BTER:77:3:273
  29. Ceriello A. Acute hyperglycaemia and oxidative stress generation. Diabet Med 1997;14:S45-9. https://doi.org/10.1002/(SICI)1096-9136(199708)14:3+3.3.CO;2-I
  30. Hu Y, Block G, Norkus EP, Morrow JD, Dietrich M, Hudes M. Relations of glycemic index and glycemic load with plasma oxidative stress markers. Am J Clin Nutr 2006;84:70-6; quiz 266-7. https://doi.org/10.1093/ajcn/84.1.70
  31. Holben DH, Smith AM. The diverse role of selenium within selenoproteins: a review. J Am Diet Assoc 1999;99:836-43. https://doi.org/10.1016/S0002-8223(99)00198-4
  32. Brown KM, Arthur JR. Selenium, selenoproteins and human health: a review. Public Health Nutr 2001;4:593-9.
  33. Frei B, Forte TM, Ames BN, Cross CE. Gas phase oxidants of cigarette smoke induce lipid peroxidation and changes in lipoprotein properties in human blood plasma. Protective effects of ascorbic acid. Biochem J 1991;277:133-8.
  34. Morrow JD, Frei B, Longmire AW, Gaziano JM, Lynch SM, Shyr Y, Strauss WE, Oates JA, Roberts LJ 2nd. Increase in circulating products of lipid peroxidation (F2-isoprostanes) in smokers. Smoking as a cause of oxidative damage. N Engl J Med 1995;332:1198-203. https://doi.org/10.1056/NEJM199505043321804
  35. Keaney JF Jr, Larson MG, Vasan RS, Wilson PW, Lipinska I, Corey D, Massaro JM, Sutherland P, Vita JA, Benjamin EJ; Framingham Study. Obesity and systemic oxidative stress: clinical correlates of oxidative stress in the Framingham Study. Arterioscler Thromb Vasc Biol 2003;23:434-9. https://doi.org/10.1161/01.ATV.0000058402.34138.11
  36. Reilly M, Delanty N, Lawson JA, FitzGerald GA. Modulation of oxidant stress in vivo in chronic cigarette smokers. Circulation 1996;94:19-25. https://doi.org/10.1161/01.CIR.94.1.19
  37. Lloyd-Jones DM, Liu K, Colangelo LA, Yan LL, Klein L, Loria CM, Lewis CE, Savage P. Consistently stable or decreased body mass index in young adulthood and longitudinal changes in metabolic syndrome components: the Coronary Artery Risk Development in Young Adults Study. Circulation 2007;115:1004-11. https://doi.org/10.1161/CIRCULATIONAHA.106.648642
  38. Erden-Inal M, Sunal E, Kanbak G. Age-related changes in the glutathione redox system. Cell Biochem Funct 2002;20:61-6. https://doi.org/10.1002/cbf.937
  39. Finkel T, Holbrook NJ. Oxidants, oxidative stress and the biology of ageing. Nature 2000;408:239-47. https://doi.org/10.1038/35041687
  40. Meagher EA, Barry OP, Burke A, Lucey MR, Lawson JA, Rokach J, FitzGerald GA. Alcohol-induced generation of lipid peroxidation products in humans. J Clin Invest 1999;104:805-13. https://doi.org/10.1172/JCI5584
  41. Barden A, Zilkens RR, Croft K, Mori T, Burke V, Beilin LJ, Puddey IB. A reduction in alcohol consumption is associated with reduced plasma F2-isoprostanes and urinary 20-HETE excretion in men. Free Radic Biol Med 2007;42:1730-5. https://doi.org/10.1016/j.freeradbiomed.2007.03.004
  42. Niskar AS, Paschal DC, Kieszak SM, Flegal KM, Bowman B, Gunter EW, Pirkle JL, Rubin C, Sampson EJ, McGeehin M. Serum selenium levels in the US population: Third National Health and Nutrition Examination Survey, 1988-1994. Biol Trace Elem Res 2003;91:1-10. https://doi.org/10.1385/BTER:91:1:1
  43. Morris JS, Spate VL, Ngwenyama RA. Determinants of selenium in the toenail biomonitor. J Radioanal Nucl Chem 2006;269:283-90. https://doi.org/10.1007/s10967-006-0380-6
  44. Morris JS, Rohan T, Soskolne CL, Jain M, Horsman TL, Spate VL, Baskett CK, Mason MM, Nichols TA. Selenium status and cancer mortality in subjects residing in four Canadian provinces. J Radioanal Nucl Chem 2001;249:421-7. https://doi.org/10.1023/A:1013243308854
  45. Sartori-Valinotti JC, Iliescu R, Fortepiani LA, Yanes LL, Reckelhoff JF. Sex differences in oxidative stress and the impact on blood pressure control and cardiovascular disease. Clin Exp Pharmacol Physiol 2007;34:938-45. https://doi.org/10.1111/j.1440-1681.2007.04643.x
  46. Kubota J, Allaway WH, Carter DL, Gary EE, Lazar VA. Selenium in crops in the United States in relation to seleniumresponsive diseases of animals. J Agric Food Chem 1967;15:448-53. https://doi.org/10.1021/jf60151a006
  47. Spallholz JE, Martin JL, Ganther HE. Selenium in Biology and Medicine. Westport, CT: AVI Publishing Company; 1981.

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Acknowledgement

Supported by : NIH, Yeungnam University