White Rice Fermented by Clostridium butyricum IDCC 9207 as an Alternative to Antibiotic having Antibacterial and Immunostimulatory Activity

항생제 대체제로서 Clostridium butyricum IDCC 9207 백미 발효물의 항균작용과 장관 면역증진효과

  • Lee, Seung-Hun (ILDONG Research Laboratories, ILDONG Pharmaceutical Co., Ltd.) ;
  • Kim, Seong-Beom (ILDONG Research Laboratories, ILDONG Pharmaceutical Co., Ltd.) ;
  • Kang, Jae-Hoon (ILDONG Research Laboratories, ILDONG Pharmaceutical Co., Ltd.) ;
  • Kang, Dae-Jung (ILDONG Research Laboratories, ILDONG Pharmaceutical Co., Ltd.)
  • 이승훈 (일동제약(주) 중앙연구소) ;
  • 김성범 (일동제약(주) 중앙연구소) ;
  • 강재훈 (일동제약(주) 중앙연구소) ;
  • 강대중 (일동제약(주) 중앙연구소)
  • Received : 2011.06.27
  • Accepted : 2011.08.16
  • Published : 2011.08.31


The antagonistic activities against animal entero-pathogenic bacteria were investigated with 444 natural substances fermented by various probiotics. A white rice product fermented (FWR) by Clostridium butyricum IDCC 9207 with a high growth inhibition of Salmonella typhimurium KCTC 2054 and Escherichia coli O157:H7 was selected. Also, a FWR was shown to suppress 8 among 21 pathogenic bacteria. In a mouse model with salmonella (${\times}10^9$ CFU/mouse) infection, 5 samples (200 ${\mu}{\ell}$/mouse/day) were fed to mice (n = 25) for 18 days. A fermented white rice containing C. butyricum IDCC 9207 (FWRCb9207) among 5 samples significantly inhibited the growth of salmonella, while in the control group (PBS, tetracycline) the number of salmonella increased. And the treatment with FWRCb9207 was found to increase the secretory immunoglobulin A (sIgA) level in the feces of salmonella-infected mice. The results obtained in this study suggest that a FWRCb9207 might be utilized as a feed additive in pigs and poultry diets.


Clostridium butyricum IDCC 9207;Fermented white rice;Antibacterial activity;Immunostimulatory activity;Secretory immunoglobulin A;Synbiotics


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