- Volume 49 Issue 2
DOI QR Code
Principles of Simulated Moving Bed Reactor(SMBR)
Simulated Moving Bed Reactor(SMBR)의 원리
- Song, Jae-Ryong (Department of Biological Engineering and Center for Advanced Bioseparation Technology, Inha University) ;
- Kim, Jin-Il (Department of Biological Engineering and Center for Advanced Bioseparation Technology, Inha University) ;
- Koo, Yoon-Mo (Department of Biological Engineering and Center for Advanced Bioseparation Technology, Inha University)
- Published : 2011.04.30
Simulated Moving Bed(SMB) process consists of multiple chromatographic columns, which are usually partitioned into four zones. Such a process characteristic allows a continuous binary separations those are impracticable in conventional batch chromatographic processes. Compared with batch chromatography, SMB has advantages of continuity, high purity and productivity. Various researches have been reported for the integration of reaction and recovery during process operation on the purpose of economics and effectiveness. Simulated Moving Bed Reactor(SMBR) is introduced to combine SMB as a continuous separation process and reactor. Several cases of SMBR have been reported for diverse reactions with catalytic, enzymatic and chemical reaction on ion exchange resin as main streams. With an early type of fixed bed using catalyst, SMBR has been developed as SMB using fluidized enzyme, SMB with immobilized enzyme and SMB with discrete reaction region. For simple modeling and optimization of SMBR, a method considering convection only is possible. A complex method considering axial dispersion and mass transfer resistance is needed to explain the real behavior of solutes in SMBR. By combining reaction and separation, SMBR has benefits of lower installation cost by minimizing equipment use, higher purity and yield by avoiding the equilibrium restriction in case of reversible reaction.
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