Principles of Simulated Moving Bed Reactor(SMBR)

Simulated Moving Bed Reactor(SMBR)의 원리

  • Song, Jae-Ryong (Department of Biological Engineering and Center for Advanced Bioseparation Technology, Inha University) ;
  • Kim, Jin-Il (Department of Biological Engineering and Center for Advanced Bioseparation Technology, Inha University) ;
  • Koo, Yoon-Mo (Department of Biological Engineering and Center for Advanced Bioseparation Technology, Inha University)
  • 송재룡 (인하대학교 생물공학과 초정밀생물분리기술연구센터) ;
  • 김진일 (인하대학교 생물공학과 초정밀생물분리기술연구센터) ;
  • 구윤모 (인하대학교 생물공학과 초정밀생물분리기술연구센터)
  • Published : 2011.04.30


Simulated Moving Bed(SMB) process consists of multiple chromatographic columns, which are usually partitioned into four zones. Such a process characteristic allows a continuous binary separations those are impracticable in conventional batch chromatographic processes. Compared with batch chromatography, SMB has advantages of continuity, high purity and productivity. Various researches have been reported for the integration of reaction and recovery during process operation on the purpose of economics and effectiveness. Simulated Moving Bed Reactor(SMBR) is introduced to combine SMB as a continuous separation process and reactor. Several cases of SMBR have been reported for diverse reactions with catalytic, enzymatic and chemical reaction on ion exchange resin as main streams. With an early type of fixed bed using catalyst, SMBR has been developed as SMB using fluidized enzyme, SMB with immobilized enzyme and SMB with discrete reaction region. For simple modeling and optimization of SMBR, a method considering convection only is possible. A complex method considering axial dispersion and mass transfer resistance is needed to explain the real behavior of solutes in SMBR. By combining reaction and separation, SMBR has benefits of lower installation cost by minimizing equipment use, higher purity and yield by avoiding the equilibrium restriction in case of reversible reaction.


  1. Shuler, M. L. and Kargi, F., Bioprocess engineering: Basic concepts, 2nd ed., Prentice Hall PTR., Upper Saddle River, NJ(2002).
  2. Harrison, R. G., Todd, P., Rudge, S. R. and Petrides, D. P., Bio- Separations Science and Engineering, 1st ed., Oxford University Press, New York, NY(2003).
  3. Broughton, D. B., "Molex Case History of A Process," Chem. Eng. Prog., 64(1), 60-72(1968).
  4. Broughton, D. B., Neuzil, R. W., Pharis, J. M. and Brearley, C. S., "The Parex Process for Recovering Paraxylene," Chem. Eng. Prog., 66(1), 70-82(1970).
  5. Ma, Z. and Wang, N.-H. L., "Standing Wave Analysis of SMB Chromatography: Linear Systems," AIChE J., 43(10), 2488-2508 (1997).
  6. Juza, M., Mazzotti, M. and Morbidelli, M. "Simulated Movingbed Chromatography and Its Application to Chirotechnology," Trends Biotechnol., 18(3), 108-118(2000).
  7. Lee, C. H. and Koo, Y. M., "Simulated Moving Bed," Korean. J. Biotechnol. Bioeng., 20(3), 192-196(2005).
  8. Afonso, C. A. M. and Crespo, J. G., "Green Separation Processes: Fundamentals and Applications," 1st ed., Wiley-VCH., Weinheim, Germany(2005).
  9. Minceva, M., Gomes, P. S., Meshko, V. and Rodrigues, A. E., "Simulated Moving Bed Reactor for Isomerization and Separation of p-xylene," Chem. Eng. J., 140(1-3), 305-323(2008).
  10. Pereira, C. S. M., Zabka, M., Silva, V. M. T. M. and Rodrigues, A. E., "A Novel Process for the Ethyl Lactate Synthesis in a Simulated Moving Bed Reactor (SMBR)," Chem. Eng. Sci., 64(14), 3301-3310(2009).
  11. Meurer, M., Althehoner, U., Strube, J. and Schmidt-Traub, H., "Dynamic Simulation of Simulated Moving Bed Chromatographic Reactors," J. Chromatogr. A., 769(1), 71-79(1997).
  12. Kulprathipanja, S., Reactive Separation Processes, 1st ed., Tayler & Francis, New York, NY(2002).
  13. Dinwiddie, J. A. and Morgan, W. A., "Fixes Bed Type Reactor," U.S. Patent No. 2,976,132(1961).
  14. Scott, C. D., Spence, R. D. and Sisson, W. G., "Pressurized, Annular Chromatograph for Continuous Separations," J. Chromutogr. A., 126(C), 381-400(1976).
  15. Shieh, M. T. and Barker, P. E., "Combined Bioreaction and Separation in a Simulated Counter-Current Chromatographic Bioreactor- Separator for the Hydrolysis of Lactose," J. Chem. Tech. Biotechnol., 66(3), 265-278(1996).<265::AID-JCTB503>3.0.CO;2-#
  16. Dunnebier, G., Fricke, J. and Klatt, K.-U. "Optimal Design and Operation of Simulated Moving Bed Chromatographic Reactors," Ind. Eng. Chem. Res., 39(7), 2290-2304(2000).
  17. Hashimoto, K., Adachi, S., Noujima, H. and Ueda, Y., "New Process Combining Adsorption and Enzyme Reaction for Producing Higher-fructose Syrup," Biotechnol. Bioeng., 25(10), 2371-2393 (1983).
  18. Zhang, Y., Hidajat, K. and Ray, A. K., "Optimal Design and Operation of SMB Bioreactor: Production of High Fructose Syrup By Isomerization of Glucose," Biochem. Eng. J., 21(2), 111-121 (2004).
  19. Borges da Silva, E. A., Ulson de Souza, A. A., de Souza, S. G. U. and Rodrigues, A. E., "Analysis of the High-fructose Syrup Production Using Reactive SMB Technology," Chem. Eng. J., 118(3), 167-181(2006).
  20. Finkler, T. F., Kupper, A. and Engell, S., "Optimization of a Reactive SMB Process Applied to the Purification of Fructose Syrup," AIChE Annual Meeting., Nov, Nashville(2009).
  21. Toumi, A., Engell, S., Diehl, M., Bock, H. G. and Schloder, J., "Efficient Optimization of Simulated Moving Bed Processes," Chem. Eng. Proc., 46(11), 1067-1084(2007).
  22. Toumi, A. and Engell, S., "Optimization-based Control of a Reactive Simulated Moving Bed Process for Glucose Isomerization," Chem. Eng. Sci., 59(18), 3777-3792(2004).
  23. Kim, K., Kim, J. I., Kim, H., Yang, J., Lee, K. S. and Koo, Y. M., "Experimental Verification of Bilevel Optimizing Control for SMB Technology," Ind. Eng. Chem. Res., 49(18), 8593-8600(2010).
  24. Natarajan, S. and Lee, J. H., "Repetitive Model Predictive Control Applied to a Simulated Moving Bed Chromatography System," Comp. Chem. Eng., 24(2-7), 1127-1123(2000).
  25. Wang, C., Klatt, K.-U., Dunnebier, G., Engell, S. and Hanisch, F., "Neural Network-based Identification of SMB Chromatographic Processes," Control. Eng. Pra., 11(8), 949-959(2003).
  26. Park, B. J., Lee, C. H., Mun, S. and Koo, Y. M., "Novel Application of Simulated Moving Bed Chromatography to Protein Refolding," Proc. Biochem., 41(5), 1072-1082(2006).
  27. Azevedo, D. C. S. and Rodrigues, A. E., "Design Methodology And Operation of a Simulated Moving Bed Reactor for the Inversion of Sucrose and Glucose-fructose Separation," Chem. Eng. J., 82(1-3), 95-107(2001).
  28. Kruglov, A. V., "Methanol Synthesis in a Simulated Countercurrent Moving-bed Adsorptive Catalytic Reactor," Chem. Eng. Sci., 49(24 Part A), 4699-4716(1994).
  29. Kawase, M., Inoue, Y., Araki, T. and Hashimoto, K., "The Simulated Moving-bed Reactor for Production of Bisphenol A," Catal. Today, 48(1-4), 199-209(1999).
  30. Ganetsos, G. and Barker, P. E. (Eds.), "Preparative and Production Scale Chromatography," Marcel Dekker, New York, 375-394 (1993).