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Zinc status and growth of Korean infants fed human milk, casein-based, or soy-based formula: three-year longitudinal study

  • Han, Young-Hee (Department of Food and Nutrition, Chungbuk National University) ;
  • Yon, Mi-Yong (Department of Food and Nutrition, Chungbuk National University) ;
  • Han, Heon-Seok (Department of Medicine, College of Medicine, Chungbuk National University) ;
  • Johnston, Kelley E. (Department of Nutrition Sciences, University of Alabama at Birmingham) ;
  • Tamura, Tsunenobu (Department of Nutrition Sciences, University of Alabama at Birmingham) ;
  • Hyun, Tai-Sun (Department of Food and Nutrition, Chungbuk National University)
  • Received : 2010.08.02
  • Accepted : 2011.01.20
  • Published : 2011.02.28

Abstract

To evaluate the effect of feeding methods on growth and zinc nutritional status of infants early in life, we monitored from birth to 36 months in 51 infants who were exclusively fed human milk (HM, n=20), casein-based formula (CBF, n=12), or soy-based formula (SBF, n=19) during the first five months of life. Zinc status was assessed by analyzing serum zinc concentrations and zinc intakes. Zinc contents in HM and formulas were measured. Zinc intake was estimated by weighing infants before and after feeding in the HM group and by collecting formula-intake records in the CBF and SBF groups. After solid foods were introduced, all foods consumed were also included to estimate zinc intake. The growth of infants in all groups was similar to that established for normal Korean infants. Human milk zinc concentrations declined as lactation progressed. Zinc concentrations in all formulas tested in this study were higher than HM and were also higher than those claimed by the manufacturers. During the first twelve months, mean serum zinc concentrations of infants were similar in all groups, although infants in the HM group consistently had the lowest zinc intake among the groups, and the overall zinc intake in infants fed SBF was highest. This finding could be explained by the difference zinc bioavailability of HM and formulas. In conclusion, infants fed HM, CBF or SBF has normal growth up to three years of age, although HM contained the lowest zinc concentration followed by CBF, then SBF.

References

  1. WHO [Internet]. Geneva: The optimal duration of exclusive breastfeeding. Report of an expert consultation; c2002 [cited 2010 June 28]. Available from: http://www.who.int/nutrition/ publications/optimal_duration_of_exc_bfeeding_report_eng.pdf.
  2. Picciano MF. Nutrient composition of human milk. Pediatr Clin North Am 2001;48:53-67. https://doi.org/10.1016/S0031-3955(05)70285-6
  3. WHO, UNICEF [Internet]. Geneva: Global strategy for infant and young child feeding; c2003 [cited 2010 June 28]. Available from: http://www.unicef.org/india/Global_Strategy_for_Infant_and_You ng_Child_Feeding__WHO_and_UNICEF.pdf.
  4. O'Connor DL, Brennan J, Merko S. Formulas for preterm and term infants. In: Thureen PJ, Hay WW, editors. Neonatal Nutrition and Metabolism, 2nd ed. New York: Cambridge University Press; 2006. p.409-36.
  5. Han YH, Yon M, Han HS, Kim KY, Tamura T, Hyun TH. Folate contents in human milk and casein-based and soya-based formulas, and folate status in Korean infants. Br J Nutr 2009;101:1769-74. https://doi.org/10.1017/S0007114508158974
  6. CODEX Alimentarius [Internet]. Standard for infant formula and formulas for special medical purpose intended for infants. Codex Stan 72-1981. Available from: http://www.codexalimentarius.net/ download/standards/288/CXS_072e.pdf.
  7. Tamura T, Johnston KE, Freeberg LE, Perkins LL, Goldenberg RL. Refrigeration of blood samples prior to separation is essential for the accurate determination of plasma or serum zinc concentrations. Biol Trace Elem Res 1994;41:165-73. https://doi.org/10.1007/BF02917226
  8. The Korean Nutrition Society. Recommended dietary allowances for Koreans, 7th revision. Seoul: Joongang Publishing Co; 2000. p.266-435.
  9. Hyun TH, Barrett-Connor E, Milne DB. Zinc intakes and plasma concentrations in men with osteoporosis: the Rancho Bernardo Study. Am J Clin Nutr 2004;80:715-21.
  10. Korea Centers for Disease Control and Prevention, Korean Pediatric Society [Internet]. Seoul: 2007 Korean children and adolescents growth standard [cited 2008 June 28]. Available from: http://www. cdc.go.kr.
  11. Hotz C, Peerson JM, Brown KH. Suggested lower cutoffs of serum zinc concentrations for assessing zinc status: reanalysis of the second national health and nutrition examination survey data (1976-1980). Am J Clin Nutr 2003;78:756-64.
  12. Schneider JM, Fujii ML, Lamp CL, Lönnerdal B, Zidenberg- Cherr S. The prevalence of low serum zinc and copper levels and dietary habits associated with serum zinc and copper in 12- to 36-month-old children from low-income families at risk for iron deficiency. J Am Diet Assoc 2007;107:1924-9. https://doi.org/10.1016/j.jada.2007.08.011
  13. Lasekan JB, Ostrom KM, Jacobs JR, Blatter MM, Ndife LI, Gooch WM 3rd, Cho S. Growth of newborn, term infants fed soy formula for 1 year. Clin Pediatr (Phila) 1999;38:563-71. https://doi.org/10.1177/000992289903801001
  14. Mendez MA, Anthony MS, Arab L. Soy-based formulae and infant growth and development: a review. J Nutr 2002;132: 2127-30.
  15. Seppo L, Korpela R, Lonnerdal B, Metsaniitty L, Juntunen- Backman K, Klemola T, Paganus A, Vanto T. A follow-up study of nutrient intake, nutritional status, and growth in infants with cow milk allergy fed either a soy formula or an extensively hydrolyzed whey formula. Am J Clin Nutr 2005;82:140-5.
  16. Vuori E, Kuitunen P. The concentrations of copper and zinc in human milk. A longitudinal study. Acta Paediatr Scand 1979; 68:33-7. https://doi.org/10.1111/j.1651-2227.1979.tb04426.x
  17. Krebs NF, Hambidge KM, Jacobs MA, Rasbach JO. The effects of a dietary zinc supplement during lactation on longitudinal changes in maternal zinc status and milk zinc concentrations. Am J Clin Nutr 1985;41:560-70.
  18. Karra MV, Kirksey A. Variation in zinc, calcium, and magnesium concentrations of human milk within a 24-hour period from 1 to 6 months of lactation. J Pediatr Gastroenterol Nutr 1988;7: 100-6. https://doi.org/10.1097/00005176-198801000-00019
  19. Lamounier JA, Danelluzzi JC, Vannucchi H. Zinc concentrations in human milk during lactation: a 6-month longitudinal study in southern Brazil. J Trop Pediatr 1989;35:31-4. https://doi.org/10.1093/tropej/35.1.31
  20. Nagra SA. Longitudinal study in biochemical composition of human milk during first year of lactation. J Trop Pediatr 1989; 35:126-8. https://doi.org/10.1093/tropej/35.3.126
  21. Nyazema NZ, Mahomva O, Andifasi W. The levels of zinc in breast milk of urban African women in Zimbabwe. Afr J Med Med Sci 1989;18:159-62.
  22. Simmer K, Ahmed S, Carlsson L, Thompson RP. Breast milk zinc and copper concentrations in Bangladesh. Br J Nutr 1990; 63:91-6. https://doi.org/10.1079/BJN19900094
  23. Moser-Veillon PB, Reynolds RD. A longitudinal study of pyridoxine and zinc supplementation of lactating women. Am J Clin Nutr 1990;52:135-41.
  24. Ohtake M, Tamura T. Changes in zinc and copper concentrations in breast milk and blood of Japanese women during lactation. J Nutr Sci Vitaminol (Tokyo) 1993;39:189-200. https://doi.org/10.3177/jnsv.39.189
  25. Hurley LS, Duncan JR, Sloan MV, Eckhert CD. Zinc-binding ligands in milk and intestine: a role in neonatal nutrition? Proc Natl Acad Sci U S A 1977;74:3547-9. https://doi.org/10.1073/pnas.74.8.3547
  26. Ohtake M, Chiba R, Mochizuki K, Tada K. Zinc and copper concentrations in human milk and in serum from exclusivelybreast- fed infants during the first 3 months of life. Tohoku J Exp Med 1981;135:335-43. https://doi.org/10.1620/tjem.135.335
  27. Craig WJ, Balbach L, Harris S, Vyhmeister N. Plasma zinc and copper levels of infants fed different milk formulas. J Am Coll Nutr 1984;3:183-6.
  28. Hambidge KM, Walravens PA, Casey CE, Brown RM, Bender C. Plasma zinc concentrations of breast-fed infants. J Pediatr 1979;94:607-8. https://doi.org/10.1016/S0022-3476(79)80025-6
  29. Sandstrom B, Cederblad A, Lonnerdal B. Zinc absorption from human milk, cow's milk, and infant formulas. Am J Dis Child 1983;137:726-9.
  30. Casey CE, Walravens PA, Hambidge KM. Availability of zinc: loading tests with human milk, cow's milk, and infant formulas. Pediatrics 1981;68:394-6.

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