Effects of a safflower tea supplement on antioxidative status and bone markers in postmenopausal women

  • Choi, Sung-Hee (Department of Food Science and Nutrition, Catholic University of Daegu) ;
  • Jang, Jeong-Hee (Department of Food Science and Nutrition, Catholic University of Daegu) ;
  • Yoon, Ji-Young (Department of Food Science and Nutrition, Catholic University of Daegu) ;
  • Hahn, Chi-Dong (Department of Obstetrics and Gynecology, Daegu Catholic Univ. Medical Center) ;
  • Choi, Young-Sun (Department of Food and Nutrition, Daegu University) ;
  • Choi, Sang-Won (Department of Food Science and Nutrition, Catholic University of Daegu)
  • Received : 2010.09.01
  • Accepted : 2010.11.03
  • Published : 2011.02.28


We conducted this study to examine the effects of safflower seed granular tea containing physiologically active polyphenols on antioxidative activities and bone metabolism. Forty postmenopausal women ages 49 to 64-years were recruited from Daegu and Gyeongbuk and were randomly assigned to either a safflower tea supplement (Saf-tea) group (n=27) or a placebo group (n=13). The Saf-tea group received 20 g of safflower seed granule tea per day containing a 13% ethanol extract of defatted safflower seeds, whereas the placebo group received a similar type of tea that lacked the ethanol extract. No significant changes in nutrient intake for either the placebo or Saf-tea groups were observed before or after the study period, except vitamin A intake increased after 6 months in the Saf-tea group. Dietary phytoestrogen intakes were similar in the Saf-tea group (60.3 mg) and placebo group (52.5 mg). Significant increases in plasma genistein and enterolactone were observed in the Saf-tea group. After 6 months of supplementation, serum levels of antioxidant vitamins such as a-tocopherol and ascorbic acid increased significantly, and TBARS levels decreased in the Saf-tea group compared to the placebo group. Serum osteocalcin levels were reduced (P<0.05) in the Saf-tea group after 6 months, whereas serum osteocalcin did not change in the placebo group. Urinary deoxypyridinoline/creatinine excretion was not different between the two groups at baseline, and did not change in either group after 6 months. Bone mineral density decreased significantly in the placebo group (P<0.01) but not in the supplemented group. It was concluded that polyphenols (72 mg/day), including serotonin derivatives, in the Saf-tea had both antioxidant and potential bone protecting effects in postmenopausal women without liver toxicity.


Supported by : Catholic University of Daegu


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