Analysis of the Components of Guibitang and Fermented Guibi-tang and their Ability to Inhibit Angiotensin-converting Enzyme

  • Liang, Chun (TKM Converging Research Division, Korea Institute of Oriental Medicine) ;
  • Yun, Na-Young (TKM Converging Research Division, Korea Institute of Oriental Medicine) ;
  • Jung, Sang-Won (TKM Converging Research Division, Korea Institute of Oriental Medicine) ;
  • Kim, Dong-Seon (TKM Converging Research Division, Korea Institute of Oriental Medicine) ;
  • Lee, Young-Jae (College of Veterinary Medicine, Jeju National University) ;
  • Ma, Jin-Yeul (TKM Converging Research Division, Korea Institute of Oriental Medicine)
  • Received : 2011.09.18
  • Accepted : 2011.11.28
  • Published : 2011.12.30


Guibi-tang is a traditional medicine used for the treatment of colds. We investigated the levels of several compounds in Guibi-tang before and after fermentation with Lactobacillus and tested their ability to inhibit angiotensin-converting enzyme. Six known compounds (decursin, decursinol angelate, nodakenin, liquiritin, formononetin, and 6-gingerol) and 2 unidentified compounds were detected in Guibi-tang (GB) and fermented Guibi-tang (FGB) by an established HPLC-DAD method. The levels of the 6 known compounds were decreased after fermentation. FGB showed more potent inhibition of angiotensin-converting enzyme activity than GB. In conclusion, fermentation with Lactobacillus affects the content of several compounds in GB and improves its angiotensin-converting enzyme inhibitory activity.


Supported by : Korea Institute of Oriental Medicine


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