Immunological Change of the Lymph Node and Lymph Follicles, Stimulated LPS in the Popliteal Lymph Node of the Early Postnatal Mice

Lipopolysaccharide 항원에 노출된 발생초기의 림프절내 B 및 T 림프구의 면역학적 변화

  • Received : 2010.12.20
  • Accepted : 2011.02.10
  • Published : 2011.02.28


This study was designed to clarify the morphometrical change of lymph node, deep cortex and lymph follicles in draining lymph nodes of young mice in response to local injection of lipopolysaccharide(LPS). 1. In the group stimulated with LPS, aged 0 day and 3 days, the number of lymph follicles were not significantly different from those of control group. 2. In the group two to four weeks after injection with LPS, aged five days and one week, the number of lymph follicles were significantly increased from those of control group. 3. In the group one to four weeks after injection with LPS, aged 0 day, three days, five days and one week, the area of lymph node and deep cortex increased about 1.5-3 times more than that of the control group. 4. In the group two to four weeks after injection with LPS, aged three days, five days and one week, the lymph follicles(the area: larger than 0.1 mm2) were increased from those of control group. 5. In the group two to four weeks after injection with LPS, aged five days and one week, the lymph follicles(the area: smaller than 0.01 mm2) were increased from those of control group. In view of these experimental findings, the formation of lymph follicles were induced by LPS stimulation from 5 days to one week after birth. The newley formed lymph follicles area in response to LPS may be less than $0.01mm^2$.


Lymph Node;Lymph Follicles;LPS


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