DOI QR코드

DOI QR Code

Effect of Swimming Exercise of c-fos, c-jun Expression in Rat Hippocampus

흰쥐 해마에서 수영운동이 c-fos, c-jun 발현에 미치는 영향

  • 이성호 (예원예술대학교 스포츠복지학부)
  • Received : 2010.09.15
  • Accepted : 2010.12.24
  • Published : 2011.01.28

Abstract

This study is to examine the effect of swimming exercise on the expression of c-fos, c-jun protein in rat hippocampus. 4-weeks aged rats and 16-weeks aged rats were used in experimental materials. All of two groups were classified into control and swimming exercise group. Swimming exercise was practiced for an hour a day. The results were got as follows after practical application in 1 day, 3days, 7 days. The expression of c-fos, c-jun protein was increased in all of the two experimental groups significantly in 1 day, 3days, 7 days. It was increased gradually in order of after 1 day, 3days, 7 days. There seems to be the effect of swimming exercise increasing the expression of c-fos, c-jun protein in hippocampus. Therefore swimming exercise can improve cognitive function such as learning and memory and prevent through activating immediate - early gene by swimming exercise. And it seems to have the positive effect on growth and recovery of nerve.

References

  1. 송문, 흰쥐 요추에서 초기발현 유전 단백과 BDNF 발현에 대한 좌골신경의 전기자극 효과. 원광대학교 일반대학원 석사학위 논문. 1998.
  2. B. J. Anderson, D. N. Rapp, D. H. Baek,, D. P. McCloskey, P. S. Coburn-Litvak, and J. K. Robinson, "exercise influences spatial learning in the radial arm maze," Physiology and Behavior, Vol.70, No.5, pp.425-429, 2000. https://doi.org/10.1016/S0031-9384(00)00282-1
  3. J. Bao, P. J. Reier, and J. B. Munson, Enhancement of c-fos expression in neurons of the rat spinal cord after partial denervation: evidence for functional plasticity, Exp Neurol, 122: pp.189-195, 1993. https://doi.org/10.1006/exnr.1993.1119
  4. C. E. Bellchambers, B. Chieng, K. A. Keay, and M. J. Christie, Swim-stress but not opioid withdrawal increases experssion of c-fos immunoreactivity in rat periaqueductal gray neurons which project to the rostral ventromedial medulla, Neuroscience, Vol.83, No.2, pp.517-524, 1998. https://doi.org/10.1016/S0306-4522(97)00399-0
  5. E. Bullitt, C. L. Lee, A. R. Light, and H. Willcockson, The effect of stimulus duration on noxious-stimulus induced c-fos expression in the rodent spinal cord, Brain Res, 580, pp.172-179, 1992. https://doi.org/10.1016/0006-8993(92)90941-2
  6. E. Carro, J. L. Trejo, and S. Busiguina, Torres-Aleman, I., Circulating insulin-like growth factor I mediates the protective effect of physical exercise against brain insults of different etiology and anatomy, Journal of Neuroscience, Vol.21, No.15, pp.5678-84, 2001. https://doi.org/10.1523/JNEUROSCI.21-15-05678.2001
  7. W. E. Cullinan, J. P. Herman, D. F. Battaglia, H. Aki, and S. J. Watson, Parrern and time cpurse of immediate early gene expression in rat brain following acute stress, Neuroendocrinology, Vol.9, No.8, pp.577-88, 1995.
  8. P. Dahlqvist, L. Zhao, I. M. Johansson, B. Mattsson, B. B. Johansson, J. R. Seckl, and T. Olsson, Environmental enrichment alters nerve growth factor-induced gene A and glucocoritcoid receptor messenger RNA expression after middle cerebral artery occlusion in rats, Neuroscience, Vol.93, No.2, pp.527-35, 1999. https://doi.org/10.1016/S0306-4522(99)00183-9
  9. R. E. Dustman, R. O. Ruhling, E. M. Russell, D. E. Shearer, H. W. Bonekat, J. W. Shigeoka, J. S. Wood, D. C. Bradford, Aerobic exercise training and improved neuropsychological function of older individuals. Neurobiology of aging, Vol.5, No.1, pp.35-42, 1984. https://doi.org/10.1016/0197-4580(84)90083-6
  10. E. B. Larson, L. Wang, J. D. Bowen, W. C. McCormick, L. Teri, P. Crane, and W. Kukull, Exercise is associated with reduced risk for incident dementia among persons 65 years of age and older, Ann. Intern. Med, 144: pp.730-781, 2006.
  11. R. Eilam, A. Davidson, I. Gozes, and M. Segal, Locomotor activity causes a rapid up-regulration of vasoactivive intestinal peptide in the rat hippocampus, hippocampus, Vol.9, No.5, pp.534-541, 1999. https://doi.org/10.1002/(SICI)1098-1063(1999)9:5<534::AID-HIPO7>3.0.CO;2-R
  12. C. F. Emery and M. Gatz, physiological and cognitive effects of an exercise program for community-residing older adults, Gerontologist, Vol.30, No.2, pp.184-188, 1990. https://doi.org/10.1093/geront/30.2.184
  13. H. B. Kim, M. H. Jang, M. C. Shin, B. V. Lim, Y. P. Kim, K. J. Kim, E. H. Kim, and C. J. Kim, Treadmill exercise increase cell proliferation in dentate gyrus of rats with streptozotocin-induce diabetes, J. Diabetes Complicat, 17: pp.29-33, 2003. https://doi.org/10.1016/S1056-8727(02)00186-1
  14. T. Herdegen, K. Kovary, J. Leah, and R. Bravo, Specific temporal and spatial distribution of JUN, FOS, and KROX-24 proteins in spinal neurons following noxious transsynaptic stimulation, J Comp Neurol, 313: pp.178-191, 1991a. https://doi.org/10.1002/cne.903130113
  15. T. Herdegen, J. D. Leah, A. Manisali, R. Bravo, and M. Zimmermann, c-JUN-lilke immunoreactivity in the CNS of the adult rat : basla and transynaptically induced expression of an immediate-early gene, Neuroscience, 41: pp.643-654, 1991b. https://doi.org/10.1016/0306-4522(91)90356-S
  16. H. H. Lee, M. S. Shin, Y. S. Kim, H. Y. Yang, H. K. Chang, T. H. Lee, C. J. Kim, S. Cho, and S. P. Hong, Early Treadmill exercise decrease intrastriatal hemorrhage-induced neuronal cell death and increases cell proliferation in the dentate gyrus of streptozotocin-induced hyperglycemic rats, J. Diabetes Complicat, 19: pp.339-346, 2005. https://doi.org/10.1016/j.jdiacomp.2005.03.006
  17. R. D. Hill, M. Storandt, Malley, The impact of long-term exercise training on psychological function in older adults, Journal of Gerontology, Vol.48, Np.1, pp.12-17, 1993. https://doi.org/10.1093/geronj/48.1.P12
  18. R. Jenkins and S. P. Hunt, Long-term increase in the levels of c-Jun mRAN and Jun protein-like immunoreactivity in motor and sensory neurons following axon damage, Neurosci. Lett, 129 : pp.107-110, 1991. https://doi.org/10.1016/0304-3940(91)90731-8
  19. J. He, K. Yamada, and T. nabeshima, A role of Fos expression in the CA3 region of the hippocampus in spatial memory formation in rats, Neuropsychopharamecology, 26: pp.259-268, 2002. https://doi.org/10.1016/S0893-133X(01)00332-3
  20. J. I. Morgan and T. Curran, Proto-oncogene transcription factors and epilepsy, Trends Pharmacol. Sci, 12: pp.343-349, 1991. https://doi.org/10.1016/0165-6147(91)90594-I
  21. B. B. Johansson and A. L. Ohlsson, Environment, social interaction, and physical activity as determinants of functional outcome after cerebral infarction in the rat, Exprimental Neurology, Vol.139, No.2, pp.322-327, 1996. https://doi.org/10.1006/exnr.1996.0106
  22. K. J. Kovacs, c-Fos as a transcription factor: a stressful (re)view from a functional map, Neurochemistry International, Vol.33, No.4, pp.289-297, 1998.
  23. D. Laurin, R. Verreault, J. Lindsay, K. MacPherson, and K. Rockwood, physical activity and risk of cognitive impairment and dementia in elderly persons, Archives of Neurology, Vol.58, No.3, pp.498-504, 2001. https://doi.org/10.1001/archneur.58.3.498
  24. J. D. Leah, T. Herdegen, and R. Bravo, Selective expression of jun proteins following axotomy & axonal transport block in peripheral nerves in the rat : evidence for a role in the regeneration process, Brain Res, 566: pp.198-207, 1991. https://doi.org/10.1016/0006-8993(91)91699-2
  25. J. Li, Mitchell, J. H., c-Fos expression in the midbrain periaqueductal gray during static muscle contraction, American Journal of Physiology. heart and Circulatory Physiology, Vol.279, Np.6, pp.2968-2993, 2000.
  26. J. F. Lopez, H. Akil, and S. J. Watson, Neural circuits mediating stress, Biological Psychiatry, Vol.46, No.11, pp.1461-171, 1999. https://doi.org/10.1016/S0006-3223(99)00266-8
  27. M. H. Jang, S. B. Jung, M. H. Lee, H. Kim, S. Lee, J. Sim, Y. J. Lee, H. H. Kim, E. K. Kim, C. J. Shin, H. S. Kim, J. S. Kim, E. H., Influence of maternal alcohol administration on c-Fos expression in the hippocampus of infant rat, Neurosci. Lett, 378: pp.44-48, 2005. https://doi.org/10.1016/j.neulet.2004.12.009
  28. M. H. Lee, H. Kim, B. V. Lim, H. K. Chang, T. H. Lee, M. H. Jang, M. C. Shin, J. S. Lee, M. S. Shin, C. J. Kim, Naloxone potentiates treadmill running-induced increase in c- Fos expression in rat hippocampus, Life Science, 73: pp.3139-3147, 2003. https://doi.org/10.1016/j.lfs.2003.06.005
  29. C. Molander, H. Hongpaisan, and J. Person, Distribution of c-Fos expressing dorsal horn neurons after electrical stimulation of low threshold sensory fibers in the chronically injured sciatic nerve, Brain Res, 644: pp.74-82, 1994. https://doi.org/10.1016/0006-8993(94)90349-2
  30. R. Molten,i, Z. Ying, and F. Gomez-Pinilla, Differential effects of acute and chronic exercise on plasticity-related genes in the rat hippocampus reveled by microarray, European Journal of Neuroscience, Vol.16(, No.6, pp.1107-1116, 2002. https://doi.org/10.1046/j.1460-9568.2002.02158.x
  31. A. Oladehin, and R. S. Waters, Location and distribution of Fos protein expression in rat hippocampus following acute moderate aerobic exercise, Experimental Brain Research, Vol.137, Np.1, pp.26-35, 2001. https://doi.org/10.1007/s002210000634
  32. R. Grimm, H. Schicknick, I. Riede, E. D. Gundelfinger, T. Herdegen, W. Zuschratter, and W. Tischmeyer, Suppression of c-Fos induction in rat brain impairs retention of a brightness discrimination reaction. Learn, Mem, 3: pp.402-413, 1997. https://doi.org/10.1101/lm.3.5.402
  33. E. T. Rolls, Hippocampo - cortical backprojections, Hippocampus, Vol.10, No.4, pp.380-388, 2000. https://doi.org/10.1002/1098-1063(2000)10:4<380::AID-HIPO4>3.0.CO;2-0
  34. J. Sandin, I. Nylander, J. Georgieva, P. A. Schott, S. O. Ogren, and L. Terenius, Hippocampal dynorphin B injections impair spatial learning in rat: a kappa-opioid receptor-mediate effect, Neuroscience, Vol.85, No.2, pp.375-382, 1998. https://doi.org/10.1016/S0306-4522(97)00605-2
  35. S. D. Vann, M. W. Brown, J. T. Erichsen, and J. P. Aggleton, Fos imaging reveals differential patterens of hippocampal and parahippocampal subfield activation in rats in response to different spatial memory tests, J. Neurosci, 20: pp.2711-2718, 2000. https://doi.org/10.1523/JNEUROSCI.20-07-02711.2000
  36. T. H. Lee, M. H. Jang, M. C. Shin, B. V. Lim, Y. P. Kim, H. H. Choi, K. S. Lee, E. H. Kim, and V. J. Kim, Dependence of rat hippocampal c-fos expression on intensity and duration of exercise, Life Sci, 72: pp.1421-1436, 2003. https://doi.org/10.1016/S0024-3205(02)02406-2
  37. Van Praag, H., Kempermann, G., Gage, F. H., Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus, Nature Neuroscience, Vol.2, No.3, pp.266-70, 1999. https://doi.org/10.1038/6368
  38. W. Wu, Potential roles of gene expression change in adult rat spinal motoneurons following axonal injury : a comparison among c-jun, off-affinity nerve growth factor receptor (LNGFR), and nitric oxide synthase (NOS), Exp Neurol, 141: pp.190-200, 1996. https://doi.org/10.1006/exnr.1996.0153
  39. Y. P. Kim, H. Kim, M. S. Shin, H. K. Chang, M. H. Jang, M. C. Shin, S. J. Lee, H. H. Lee, J. H. Yoon, I. G. Jeong, and C. J. Kim, Age-dependence of the effect of treadmill exercise on cell prolifration in the dentate gyrus of rats, Neurosci. lett, 355: pp.152-154, 2004. https://doi.org/10.1016/j.neulet.2003.11.005
  40. Y. S. Jee, I. G. Ko, Y. H. Sung, J. W. Lee, Y. S. Kim, S. E. Kim, B. K. Kim, J. H. Seo, M. S. Shin, H. H. Cho, H. J. Cho, and C. J. Kim, Effect of treadmill exercise on memory and c-fos expression in the hippocampus of the rats with intracerebroventrocular injection of streptozotocin, Neuroscience letters, 443: pp.188-192, 2008. https://doi.org/10.1016/j.neulet.2008.07.078