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Effects of Fermented Turmeric Extracts on the Obesity in Rats Fed a High-Fat Diet

강황 발효액이 고지방 섭취 흰쥐의 비만에 미치는 효과

  • Yang, Cheul-Young (College of Health Industry, Eulji University) ;
  • Cho, Mi-Jin (Department of Food Science and Biotechnology of Animal Resources, College of Animal Bioscience & Technology, Konkuk University) ;
  • Lee, Chi-Ho (Department of Food Science and Biotechnology of Animal Resources, College of Animal Bioscience & Technology, Konkuk University)
  • 양철영 (을지대학교 보건산업대학) ;
  • 조미진 (건국대학교 동물생명과학대학) ;
  • 이치호 (건국대학교 동물생명과학대학)
  • Received : 2010.08.27
  • Accepted : 2010.10.15
  • Published : 2011.02.28

Abstract

This study was designed to investigate the effects of fermented turmeric extract on body weight, abdominal fat mass and biochemical markers related to obesity in rats fed high fat diet. Turmeric and brown sugar was equally mixed and fermented for one year. Wistar rats (weighing about 125 g (15 rats)) were divided into three groups: high fat diet (20.9%) and brown sugar 7.2% (HFD), turmeric powder in replace of corn starch 12.8%, brown sugar 7.2% (TP), fermented turmeric powder 20% (FTP) for four weeks. The final body weight was about 425g. The retroperitoneal fat weights in TP group showed the tendency to decrease regardless of feed intake in the rats. Serum levels of total cholesterol and LDL-cholesterol in the FTP group showed the lowering tendency than those of the HFD group (p<0.05). Serum levels of leptin, adiponectin and aspartate aminotransferase (AST) in the FTP group was significantly (p<0.05) lower than that of the HFD group, and serum level of tumor necrosis factor-$\alpha$ (TNF-$\alpha$) in all the groups were similar. These results suggest that fermented turmeric extract might be effective to prevent obesity in rats fed high fat diet.

Keywords

Fermented turmeric;Rats;Obesity;Leptin;AST

Acknowledgement

Supported by : 을지대학교

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