Association of Single Nucleotide Polymorphism (SNP) in the PGK 2 Gene with Growth Traits in Pigs

돼지 PGK 2 유전자의 단일염기다형성 및 성장 형질과의 연관성 구명

  • 장홍철 (농촌진흥청 국립축산과학원) ;
  • 김상욱 (충북대학교 축산학과) ;
  • 임다정 (농촌진흥청 국립축산과학원) ;
  • 김재영 (농촌진흥청 국립축산과학원) ;
  • 조규호 (농촌진흥청 국립축산과학원) ;
  • 김명직 (농촌진흥청 국립축산과학원) ;
  • 이지웅 (전남대학교 동물자원학부) ;
  • 최봉환 (농촌진흥청 국립축산과학원) ;
  • 김태헌 (농촌진흥청 국립축산과학원)
  • Received : 2010.08.24
  • Accepted : 2010.12.02
  • Published : 2011.02.28


The purpose of this study was to analyse of association between growth traits and single nucleotide polymorphisms (SNPs) polymorphism of phosphoglycerate kinase 2 (PGK 2) gene in pigs. The birth weight of piglet influences on weaning weight and survival rate that are import economic traits in pig industry. Also, these growth traits are representative factor to decrease a period getting to marketing weight as well as growth rate in pig. The PGK 2 is an isozyme that catalyzes the first ATP-generating step in the glycolytic pathwayand important enzyme related with energy metabolism. Twenty of SNPs were discoveredby genome structure analysis that compares the sequence on promoter and transcription region of PGK 2 gene in porcine chromosome 7. An association between PGK 2 SNPs and growth traits was analyzed in $F_2$ reciprocal-crossbred population between korean native pig (KNP) and Landrace. Association analysis indicated that polymorphism of the PGK 2 gene promoter region has significant effects on weight at birth (p<0.01) and weight at 3 weeks of age (p<0.0001). These results suggest that PGK 2 gene polymorphism was associated with energy metabolism and physiological function of growth in pig.


Grant : DNA마커 도움선발(MAS, Marker-Assisted Selection)을 이용한 한국 재래돼지 개량과 상업적 비육 흑돼지 계통조성

Supported by : 농촌진흥청


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