불소를 함유한 PVA 고분자 접착 테잎의 불소 유리 효과

  • Received : 2011.05.10
  • Accepted : 2011.11.10
  • Published : 2011.11.30


The purpose of this study is to investigate the residual fluoride concentration of polymer adhesive tape in oral cavity which is made by spraying NaF on PVA base and to compare with Fluoride varnish(Cavityshiled$^{TM}$). Experimental groups were divided into two according to application methods; Group 1(NaF-PVA tape) and Group 2(Cavityshiled$^{TM}$). Topical fluoride was applied to 20 healthy adults aged from 25 to 30. Fluoride concentration in unstimulated whole saliva was measured by fluoride-sensitive electrode for 72 hours. 1. Until 72 hours after application in every group, significantly higher fluoride concentration was shown in saliva than baseline value(p<0.05). 2. At 2, 3 and 4 hours after application, Group 2 revealed significantly higher fluoride concentration than Group 1(p<0.05). 3. At 24, 48 and 72 hours after application, there was no significance(p>0.05). Although the residual fluoride concentration of saliva and the amount of fluoride of NaF-PVA tape are lower than those of Cavityshield$^{TM}$, NaF-PVA tape is considered to be more effective since it showed almost the same result as Cavityshield$^{TM}$. Therefore, NaF-PVA tape is expected to be a great fluoride application material.


Fluoride tape;Fluoride varnish;Fluoride-ion concentration;Poly vinyl alcohol(PVA);Unstimulated saliva


  1. Knuston JW, Armstrong W : The effect of topically applied sodium fluoride on dental caries experience. Publ Health Rep, 58:1701-1715, 1943.
  2. Arends J, Nelson DGA, Dijkman AG et al. : Effect of various fluorides on enamel structure and chemistry. Cariology today, 245-258, 1984.
  3. Ten Cate JM : In vitro sudies on effects of fluoride on de- and remineralization. J Dent Res, 69:614-619, 1990.
  4. Mellberg JR, Ripa LW : Fluoride in preventive Dentistry : Theory clinical applications. Chicago ; Quintessence Publishing CO, 181-214, 1983.
  5. Brudevold F, Naujork R : Caries-preventive fluoride treatment of the individual. Caries Res, 12:52-64, 1973.
  6. Kirkegaard E : In vitro Fluoride uptake in human dental enamel from various fluoride solution. Caries Res, 11:16-23, 1977.
  7. Mellberg JR, Nicholson CR, Trubman A : The acquisition of fluoride by tooth enamel in vivo from selfapplied APF gel and prophylaxis paste. Caries Res, 7:173-178, 1973.
  8. Cobb B, Roizer G, Bawden JW : A clinical study of the caries APF solution and thixotropic gel. Pediatr Dent, 2:263-266, 1980.
  9. Hicks MJ, Flaitz CM, Garcia-Godoy F : Root-surface caries formation: effect of in vitro APF treatment. J Am Dent Assoc, 129:449-453, 1998.
  10. Adair SM : Current fluoride theraphy in dentistry for children. Current Opinion Dent, 1:583-591, 1991.
  11. 최원혁, 김은정, 김현정 등 : APF gel이 심미수복재료의 표면에 미치는 영향. 대한소아치과학회지, 33:281-289, 2006.
  12. Beltran-Aguilar ED, Goldstein JW, Lockwood SA : Fluoride varnishes. A review of their clinical use, cariostatic mechanism, efficacy and safety. J Am Dent Assoc, 131:589-596, 2000.
  13. Grabe P, Ellefsen B, Birkhed D, et al. : Oral retention of fluoride from a mucosa adhesive paste (Orabase) supplemented with NaF-a pilot study. Oral Health Prev Dent Dent, 3:195-200, 2005.
  14. Wu H, Zhang ZX, Zhao HP, et al. : Preparation of sodium fluoride-loaded gelatin microspheres, characterization and cariostatic studies. J Microencapsul, 21:889-903, 2004.
  15. De Moor RJ, Verbeeck RM : Effect of encapsulation on the fluoride release from conventional glass ionomers. Dent Mater, 18:370-375, 2002.
  16. Creanor SL, Al-Harthy NS, Gilmour WH, et al. : Fluoride release from orthodontic cements-effect of specimen surface area and depth. J Dent, 31:25-32, 2003.
  17. Todd MA, Staley RN, Kanellis MJ, et al. : Effect of a fluoride varnish on demineralization adjacent to orthodontic brackets. Am J Orthod Dentofacial Orthop, 116:159-167, 1999.
  18. Toumba KJ, Curson ME : A clinical trial of a slow-releasing fluoride device on children. Cries Res, 39:195-200, 2005.
  19. Marini I, Checchi L, Vecchiet F, et al. : Intraoral fluoride releasing device: a new clinical therapy for dentine sensitivity. J Periodontol. 71:90-5, 2000.
  20. Arends J, Tem Cate JM : Tooth mineralization. J Cryst Growth, 53:135-147, 1981.
  21. Margolis HC, Moreno EC, Murphy BJ : Effect of low levels of foluoride in solution on enamel demineralization in vitro. J Dent Res, 65:23-29, 1986.
  22. Oliveby A, Ekstrand J, Lagerlof F : Effect of salivary flow rate on salivary fluoride clearance after use of fluoride-containing chewing gum. Caries Res, 21:393-201, 1987.
  23. Newbrun E : Topical fluoride therapy : Discussion of some aspects of toxicology, safety and efficacy. J Dent Res, 67:114, 1988.
  24. Beal JF, Rock WP : Fluoride gels. a laboratory and clinical investigation. Br Dent J, 140:307-310, 1976.
  25. Spoerke DG, Bennett DL, Gullekson DJK : Tosicity related to acute low dose sodium fluoride ingestion. J Family Pract, 10:139-140, 1980.
  26. Duxbury AJ, Leach FN, Duxabury JT : Acute fluoride toxicity. Br Dent J, 153:64-66, 1982.
  27. Ekstrand J, Koch G, Lindgren LE : Pharmacokinetics of fluoride gels in children and adult. Caries Res, 15:213-220, 1981.
  28. Lecompte EJ, Doyle TE : Oral fluoride retention following various topical application technique in children. J Dent Res, 61:1397-1400, 1982.
  29. Whiteford GM, Allmann DW, Shahed AR : Topical fluorides : Effects on physiologic and biochemical process. J Dent Res, 66:1072-1078, 1987.
  30. Wei SHY, Hattab FN : Enamel fluoride uptake from a new APF foam. Pediatr Dent, 10:111-114, 1988.
  31. Kula KS, Webb L, Kula TJ : Effect of 1- and 4-minute treatments of topical fluorides on a composite resin. Pediatr Dent, 18:24-28, 1996.
  32. Toumba KJ, Curson ME : A clinical trial of a slow-releasing fluoride device on children. Cries Res, 39:195-200, 2005.
  33. Bottenberg P, Cleymaet R, de Muynck C, et al. : Comparison of salivary fluoride concentration after administration of a bioadhesive slow-release tablet and a conventional fluoride tablet. J Pharm Pharmacol, 44:684-686, 1992.
  34. Gaffar A, Hunter CM, Mirajkar YR : Applications of polymers in dentifrice and mouthrinses. J Clin Dent, 13:138-148, 2002.
  35. 박승효, 이상호, 이난영 : 불소 테잎 적용 후 시간변화에 따른 타액 내 불소농도. 대한소아치과학회지, 36:377-386, 2009.
  36. 이종흔, 김중수 : 구강생리학, 신광출판사, 서울, 175-201, 1989.
  37. Opydo-Szymaczek J, Opydo J : Salivary Fluoride concentrations and fluoride ingestion following application of preparations containing high concentration of fluoride. Biol Trace Elem Res, 137:159-167, 2010.
  38. Duckworth RM, Morgan SN, Murray AM : Fluoride in saliva and plaque following use of fluoride-containing mouthwashes. J Dent Res, 66:1730-1734, 1987.
  39. Oliveby A, Twetman, Ekstrand J : Diurinal fluoride concentration in whole saliva in children living in a high- and a low-fluoride area. Caries Res, 24:44-47, 1990.
  40. 권호근, 김백일, 이영희, 김권수 등 : 불소치약 사용후 시간변화에 따른 구강내 타액의 불소농도변화에 관한 연구. 대한구강보건학회지, 20:555-567, 1996.
  41. Jenkin GN, Edgar WM : Distribution and forms of fluoride in saliva and plaque. Caries Res, 11:226-242, 1977.
  42. Zero DT, Fu J, Espeland MA : Comparison of fluoride concentrations in unstimulated whole saliva following use of a fluoride dentifrice and a fluoride rinse. J Dent Res, 67:1257-1262, 1988.
  43. Lindahl CB : Fluoride and monofluorophosphate analysis. Caries Res, 17:9-20, 1983.
  44. Retief DH, Summerlin DJ, Harris BE : An evaluation of three procedures for fluoride analysis. Caries Res, 19:248-254, 1985.
  45. Front MS, Ross JW Jr : Use of total ionic strength adjustment buffer for electrode determination of fluoride in water supplies. Anal Chem, 40:1169-1171, 1968.
  46. Edelstein BL, Cottrel D : Comparison of colorimeter and electrode analysis of water fluoride. Pediatr Dent, 14:47-49, 1992.
  47. Weinberger SJ, John DW, Wright GZ : A comparison of two systems for measuring water fluoride ion level. Clin Prev Dent, 11:19-22, 1989.
  48. Saravana KR, Vijayalakshmi R : Nanotechnology in dentistry. Indian J Dent Res, 17:62-65, 2006.
  49. Yao K, Gron P : Fluoride concentration in duct saliva and in whole saliva. Caires Res, 4:321-331, 1970.
  50. Shannon IL : Biochemistry of fluoride in saliva. Caries Res, 11:206-225, 1977.
  51. Ten Bosch JJ, Booi M : A quantitative comparison of methods measuring fluoride in solutions or in enamel. J Dent Res, 71:945-948, 1992.
  52. Dowes C, Weatherell JA : Kinetics of fluoride in the oral fluids. J Dent Res, 69:638-644, 1990.
  53. Heintze ULF, Petersson LG : Accumulation and clearance of fluoride in human mixed saliva after different topical fluoride treatments. Swed Dent J, 3:141-148, 1979.
  54. Zero DT, Roubertas RF, Fu J, et al.: Fluoride concentrations in plaque, whole saliva, and ductal saliva after application of home-use topical fluorides. J Dent Res, 71:1768-1775, 1992.
  55. Leach SA : Reactions of fluoride with posered enamel and dentine. Report of a chemical study over a range of concentrations of sodium fluoride. Br Dent J, 106:133-142, 1959.
  56. Lagerlof F, Saxegaaed E, Barkvoll P, et al. : Effect of inorganic ortophosphate and pyrophosphate on dissolution of calcium fluoride in water. J Dent Res, 67:447-449, 1988.
  57. Sreebny LM : Xerostomia: diagnosis, management and clinical complications. 2nd ednition. British Dental Association, London, 43-6, 1996.
  58. C.A Finch, Ploy(vinylalcohol), 2nd edition, NewYork, Wiley, 1992.
  59. Shafee EE, Naguib HF : Water sorption in cross-linked poly(vinyl alcohol) networks. Polymer, 44:1647-1653, 2003.
  60. Korsmeyer RW, Peppas NA : Effect of the morphology of hydrophilic polymeric matrices on the diffusion and release of water soluble drugs, J Membr Sci, 9:211-227, 1981.

Cited by

  1. A Comparison of the Amount of Fluoride Ion Released and Remineralization Effect on the Initial Caries Lesion of the Various Fluoride Varnishes vol.43, pp.4, 2016,


Supported by : 한국연구재단