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Skin Hydration and Collagen Synthesis of AF-343 in HS68 Cell Line and NC/Nga Mice by Filaggrin Expression and Suppression of Matrix Metallopreteinase

Cho, Jae-We;Jeong, Yeon-Su;Han, Ji-Won;Chun, Young-Jin;Kim, Hyun-Kyu;Kim, Min-Young;Kim, Beom-Joon;Park, Ki-Moon;Kim, Jong-Keun;Kim, Jae-Hyun;Cho, Soo-Muk

  • Received : 2011.10.01
  • Accepted : 2011.10.18
  • Published : 2011.12.01

Abstract

Extract of Taraxacum platycarpum (AF-343) has been reported to have several biological properties such as skin hydration and anti-inflammatory effects. Although clinical evidences of skin hydration and antiinflammatory effect were proven in clinical trial, precise mechanism of skin hydration was not fully understood yet. In this study, we have focused skin hydration mechanism related filaggrin, collagen, and matrix metalloproteinase (MMP) in vitro and animal study. Herein, skin hydration mechanism of AF-343 is due to recovery of filaggrin in mice model and increased production of collagen with suppression of matrix MMP in vitro fibroblast cell line.

Keywords

Taraxacum platycarpum;Type I collagen;MMP-1;Smad2/3

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Cited by

  1. Antioxidative Characteristics of Dried Type Sodium Reduced Chicken Bibimbap Using Dandelion Complex Extract Powder of AF-343 as a Home Meal Replacement vol.31, pp.3, 2015, https://doi.org/10.9724/kfcs.2015.31.3.378
  2. vol.82, pp.2, 2018, https://doi.org/10.1080/09168451.2017.1417021

Acknowledgement

Grant : Research Program for Agricultural Science & Technology Development

Supported by : National Academy of Agricultural Science, Rural Development Administration