Prevention of Inflammatory Bowel Disease using Fermented Milk Including Probiotics

프로바이오틱스 섭취를 통한 염증성 장 질환의 완화

  • Lee, Jin (Division of Food Bioscience and Technology, College of Life Sciences and Biotechnology, Korea University) ;
  • Yun, Hyun-Sun (Division of Food Bioscience and Technology, College of Life Sciences and Biotechnology, Korea University) ;
  • Kim, Sae-Hun (Division of Food Bioscience and Technology, College of Life Sciences and Biotechnology, Korea University) ;
  • Jeon, Woo-Min (Division of Animal Science, Sahmyook University)
  • 이진 (고려대학교 식품공학부) ;
  • 윤현선 (고려대학교 식품공학부) ;
  • 김세헌 (고려대학교 식품공학부) ;
  • 전우민 (삼육대학교 동물과학부)
  • Received : 2010.11.12
  • Accepted : 2010.11.22
  • Published : 2010.11.30

Abstract

For centuries, probiotics have been known to promote health and prevent diseases. In recent times, modulation of diseases related to the immune function by probiotics has been recognized as very important to the health of the host's gut. Inflammatory bowel diseases (IBDs) are the most frequently studied diseases in which probiotic administration has been tested as a potential therapy. Various in vitro and in vivo studies have been performed. The studies discussed in this review suggest several mechanisms: probiotics could modulate the gut microflora by competing with disease-causing pathogenic bacteria and could directly regulate the mucosal immune system, which activates the innate and adaptive immune systems. In addition, human clinical trials have shown alleviation of disease symptoms of ulcerative colitis (UC), Crohn's disease, etc. This study aimed to understand the molecular mechanisms underlying immune modulation by probiotics and review studies on the functional aspect of IBD alleviation by probiotics. With more scientific studies confirming the effect of probiotics, this therapy holds promise for use in alternative medicine and/or pharmaceutical preparations, given the long history of safe consumption of probiotics.