Correlation of Active Ingredients and End-use Products Pesticide on Irritation and Sensitization

농약원제 및 제품 간의 자극성 및 감작성 상관성 평가 연구

  • 이제봉 (농촌진흥청 국립농업과학원) ;
  • 신진섭 (농촌진흥청 국립농업과학원) ;
  • 박연기 (농촌진흥청 국립농업과학원) ;
  • 정미혜 (농촌진흥청 국립농업과학원) ;
  • 홍순성 (농촌진흥청 국립농업과학원) ;
  • 임건재 (농촌진흥청 국립농업과학원) ;
  • 강규영 (경상대학교 환경생명화학과)
  • Received : 2010.04.02
  • Accepted : 2010.04.15
  • Published : 2010.06.30

Abstract

This study was investigated to review the potentials of irritation and skin sensitization of active ingredients and end-use products of pesticides for pesticide registration, prediction of irritation and sensitization, and data requirements for other purposes. Pesticide irritation and sensitization referred to the Pesticide Manual(14th edition), while toxicity was evaluated based on the data submitted by the pesticide registrant. Totally 148 active ingredients and 149 end-use products were analyzed to compare the positive response, formulation type, and correlation between active ingredients and products. Among active ingredients, ratio of positive response to skin irritation, eye irritation, and skin sensitization were 18.8, 47.0 and 20.6% respectively. While, positive response to skin irritation, eye irritation, and skin sensitization of the products were 14.9, 38.9 and 23.6%, respectively. Emulsifiable concentrate showed the highest positive response among formulation types showing skin irritation 31.3%, eye irritation 81.3%, and skin sensitization 31.3%. On the other hand granule type showed the lowest response with skin 4.8, eye 14.3 and sensitization 14.8%. There was no correlation by active ingredient content on irritation and sensitization of products. However, both active ingredients and products showed same positive response were skin 73.1%, skin sensitization 66.2%, and eye irritation 44.7%. By the these results, correlation between technical grade of active ingredients and end-use products would be use for pesticide management at the screening stage, especially skin irritation and skin sensitization.

Keywords

Pesticide;Irritation;Sensitization

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