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Ingredients Analysis and Biological Activity of Fermented Angelica gigas Nakai by Mold

곰팡이 발효 참당귀의 유효성분 분석 및 생리활성 작용

  • Cha, Jae-Young (Technical Research Institute, Daesun Distilling Co., Ltd.) ;
  • Kim, Hyun-Woo (Technical Research Institute, Daesun Distilling Co., Ltd.) ;
  • Heo, Jin-Sun (Sancheong Institute of Medicinal Herb on Foundation) ;
  • Ahn, Hee-Young (Department of Biosciences, Graduate School, Dong-A University) ;
  • Eom, Kyung-Eun (Department of Biosciences, Graduate School, Dong-A University) ;
  • Heo, Su-Jin (Department of Biosciences, Graduate School, Dong-A University) ;
  • Cho, Young-Su (Department of Biotechnology, Dong-A University)
  • 차재영 (대선주조(주) 기술연구소) ;
  • 김현우 (대선주조(주) 기술연구소) ;
  • 허진선 ((재)산청한방약초연구소) ;
  • 안희영 (동아대학교 대학원 의생명과학과) ;
  • 엄경은 (동아대학교 대학원 의생명과학과) ;
  • 허수진 (동아대학교 대학원 의생명과학과) ;
  • 조영수 (동아대학교 생명공학과)
  • Received : 2010.07.09
  • Accepted : 2010.09.13
  • Published : 2010.09.30

Abstract

Three mold strains, Aspergillus oryzae (AOFAG), Aspergillus kawachii (AKFAG), and Monascus purpureus (MPFAG) were used for fermentation of Angelica gigas Nakai powder. The contents of polyphenolic compounds, flavonoids, minerals, decursin and decursinol angelate and the activities of DPPH (${\alpha},{\alpha}'$-diphenyl-$\beta$-picrylhydrazyl) free radical scavenging, reducing power, and tyrosinase were measured. The highest contents of phenolic compound and flavonoid were NFAG at 2.78% and MPFAG at 1.18%, respectively. Major minerals were K, Mg, Fe, Na and Ca. Decursin and decursinol angelate were the major ingredients of Angelica gigas according to HPLC analysis. Decursin area was higher in all fermented Angelica gigas than in NFAG. The activities of free radical scavenging and tyrosinase were stronger in all fermented Angelica gigas than NFAG. However, the Fe/Cu reducing powers were stronger in NFAG than all fermented Angelica gigas. Overall, these results may provide the basic data needed to understand the biological activities and chemical characteristics of Angelica gigas fermented by mold for the development of functional foods.

Keywords

Fermented-Angelica gigas Nakai;decursin;decursinol angelate;antioxidation;tyrosinase

Acknowledgement

Supported by : 동아대학교

References

  1. Abe, N., T. Murata, and A. Hirota. 1998. Novel DPPH radical scavengers, bisorbicillinol and demethyltrichodimerol, from a fungus. Biosci. Biotechnol. Biochem. 62, 661-666. https://doi.org/10.1271/bbb.62.661
  2. Ahn, M. J., M. K. Lee, Y. C. Kim, and S. H. Sung. 2008. The simultaneous determination of coumarins in Angelica gigas root by high performance liquid chromatography-diode array detector coupled with electrospray ionization/ mass spectrometry. J. Pharm. Biomed. Anal. 46, 258-266. https://doi.org/10.1016/j.jpba.2007.09.020
  3. Ahn, Y. J., B. R. Won, M. K. Kang, J. H. Kim, and S. N. Park. 2009. Antioxidant activity and component analysis of fermented Lavamdula angustifolia extracts. J. Soc. Cosmet. Scientists Korea 35, 125-134.
  4. Cabanes, J., S. Chazarra, and F. Garcia-Carmona. 1994. Kojic acid, a cosmetic skin whitening agent, is a slow binding inhibitor of catecholase activity of tyrosinase. J. Pharm. Pharmacol. 46, 982-985. https://doi.org/10.1111/j.2042-7158.1994.tb03253.x
  5. Cha, J. Y., H. J. Kim, C. H. Chung, and Y. S. Cho. 1999. Antioxidative activities and contents of polyphenolic compound of Cudrania tricuspidata. J. Korean Soc. Food Sci. Nutr. 28, 1310-1315.
  6. Cha, J. Y., H. Y. Ahn, K. E. Eom, B. K. Park, B. S. Jun, J. C. Park, C. H. Lee, and Y. S. Cho. 2009. Effects of Monascus-fermented Korean red ginseng powder on the contents of serum lipid and tissue lipid peroxidation in alcohol feeding rats. J. Life Sci. 19, 983-993. https://doi.org/10.5352/JLS.2009.19.7.983
  7. Cha, J. Y., Y. S. Kim, P. D. Kang, H. Y. Ahn, K. E. Eom, and Y. S. Cho. 2010. Biological activity and chemical characteristics of fermented silkworm powder by mold. J. Life Sci. 20, 237-244. https://doi.org/10.5352/JLS.2010.20.2.237
  8. Cha, J. Y., H. J. Yang, J. J. Jeong, W. S. Seo, J. S. Park, M. Ok, and Y. S. Cho. 2010. Tyrosinase inhibition activity and antioxidant capacity by fermented products of some medicinal plants. J. Life Sci. 20, 940-947. https://doi.org/10.5352/JLS.2010.20.6.940
  9. Choi, Y. M., J. B. Gu, M. H. Kim, and J. S. Lee. 2008. Antioxidant and antiproliferative activities of methanolic extracts from thirty Korean medicinal plants. Food Sci. Biotechnol. 17, 1235-1239.
  10. Duncan, D. B. 1959. Multiple range and multiple F test. Biometrics 1, 1-42. https://doi.org/10.1002/bimj.19590010102
  11. Han, G. J., D. S. Shin, and M. S. Jang. 2008. A study of the nutritional composition of Aralica continentalis Kitagawa and Aralica continentalis Kitagawa leaf. Korean J. Food Sci. Technol. 40, 680-685.
  12. Hong, M. W. 1972. Statistical studies on the formularies of oriental medicine (I) prescription frequency and their origin distribution of herb drugs. Korean J. Pharmacog. 3, 57-64.
  13. Hwang, J. B. and M. O. Yang. 1997. Comparison of chemical components of Angelica gigas Nakai and Angelica acutiloba Kitagawa. Korean J. Food Sci. Technol. 29, 1113-1118.
  14. Jee, S. O. 2009. Antioxidant activities and whitening effect of the mulberry (Morus alba L.) root bark extracts. Korean J. Plant Res. 22, 145-151.
  15. Jia, Z., M. Tang, and J. Wu. 1999. The determination of flavonoid contents in mulberry and thier scavenging effects on superoxide radicals. Food Chem. 64, 555-559. https://doi.org/10.1016/S0308-8146(98)00102-2
  16. Jung, S. W., N. K. Lee, S. J. Kim, and D. S. Han. 1995. Screening of tyrosinase inhibitor from plants. Korean J. Food Sci. Technol. 27, 891-896.
  17. Kim, C. H., M. C. Kwon, H. G. Han, C. S. Na, H. G. Kwak, G. P. Choi, U. Y. Park, and H. Y. Lee. 2008. Skin-whitening and UV-protective effects of Angelica gigas Nakai extracts on ultra high pressure extraction process. Korean J. Medicinal Crop Sci. 16, 255-260.
  18. Kim, E. Y., I. H. Baik, J. H. Kim, S. R. Kim, and M. R. Rhyu. 2004. Screening of the antioxidant activity of some medicinal plants. Korean J. Food Sci. Technol. 36, 333-338.
  19. Kim, H. S. and S. W. Joung. 2006. Effective components and nitrile scavenging ability of root and leaves a Angelica gigas Nakai. Korean J. Food Cookery Sci. 22, 957-965.
  20. Kim, K. M., J. Y. Jung, S. W. Hwang, M. J. Kim, and J. S. Kang. 2009. Isolation and purification of decursin and decursinol angelate in Angelica gigas Nakai. J. Korean Soc. Food Sci. Nutr. 38, 653-656. https://doi.org/10.3746/jkfn.2009.38.5.653
  21. Lee, J. H. and S. R. Lee. 1994. Analysis of phenolic substances content on Korea plant foods. Korean J. Food Sci. Technol. 26, 310-316.
  22. Lee, J. J., A. R. Kim, Y. N. Seo, and M. Y. Lee. 2009. Comparison of physicochemical composition of three species of genus Angelica. Korean J. Food Preserv. 16, 94-100.
  23. Masamoto, Y., H. Ando, Y. Murata, Y. Shimoishi, M. Tada, and K. Takahata. 2003. Mushroom tyrosinase inhibitory activity of esculetin isolated from seeds of Euphorbia lathyris L. Biosci. Biotechnol. Biochem. 67, 631-634. https://doi.org/10.1271/bbb.67.631
  24. Maxson, E. and L. Rooney. 1972. Evaluation of methods for tannin analysis in sorghum grain. Cereal Chem. 49, 719-729.
  25. Oh, S. H., Y. S. Cha, and D. S. Choi. 1999. Effects of Angelica gigas Nakai diet on lipid metabolism, alcohol metabolism and liver function of rats administered with chronic ethanol. J. Korean Soc. Agric. Chem. Biotechnol. 42, 29-33.
  26. Oh, S. L., S. S. Kim, B. Y. Min, and D. H. Chung. 1990. Composition of free sugars, free amino acids, non-volatile organic acids and tannins in the extracts of L. chinensis M., A. acutiloba K., S. chinesis B. and A. sessiliflorum S. Korean J. Food Sci. Technol. 22, 76-81.
  27. Park, J. C., J. Y. Cha, C. H. Lee, E. S. Doh, I. K. Kang, and Y. S. Cho. 2009. Biological activities and chemical characteristics of Monascus-fermented Korea red ginseng. J. Life Sci. 19, 1553-1561. https://doi.org/10.5352/JLS.2009.19.11.1553
  28. Park, K. W., S. R. Choi, M. E. Shon, I. Y. Jeong, K. S. Kang, S. T. Lee, K. H. Shim, and K. I. Seo. 2007. Cytotoxic effects of decursin from Angelica gigas Nakai in human cancer cells. J. Korean Soc. Food Sci. Nutr. 36, 1385-1390. https://doi.org/10.3746/jkfn.2007.36.11.1385
  29. Park, S. J., S. W. Song, D. H. Seong, D. S. Park, S. S. Kim, J. Gou, J. H. Ahn, W. B. Yoon, and H. Y. Lee. 2009. Biological activities in the extract if fermented Codonopsis lanceolata. J. Korean Soc. Food Sci. Nutr. 38, 983-988. https://doi.org/10.3746/jkfn.2009.38.8.983
  30. Park, S. S., Y. B. Ryu, Y. H. Lee, Y. U. Cho, S. J. Cho, Y. J. Choi, K. H. Park, and S. W. Gal. 2007. Inhibition of melanin synthesis by mycelial culture broth of Paecilomyces japonica in the mulberry leaf extract. J. Life Sci. 17, 816-821. https://doi.org/10.5352/JLS.2007.17.6.816
  31. Pyo, Y. H. 2007. Comparison of antioxidant potentials in methanolic extracts from soybean and rice fermented with Monascus sp. Food Sci. Biotechnol. 16, 451-456.
  32. Ryu, K. S., N, D, Hong, and Y. Y. Kim. 1990. Studies on the coumarin constituents of the root of Angelica gigas Nakai. Isolation of decursinol angelate and assay of decursinol angelate and decursin. Korean J. Pharmacogn. 21, 64-68.
  33. Seong, N. S., S. W. Lee, K. S. Kim, and S. T. Lee. 1993. Environmental variation of decursin content in Angelica gigas. Korean J. Crop Sci. 38, 60-65.
  34. Shon, M. E. 2007. Antioxidant and anticancer activities of Poria cocos and Machilus thunbergii fermented with mycelial mushrooms. Food Indus. Nutr. 12, 51-57.
  35. Son, J. W., H. J. Kim, and D. K. Oh. 2008. Ginsenoside Rd production from the major ginsenoside Rb(1) by beta-glucosidase from Thermus caldophilus. Biotechnol. Lett. 30, 713-716. https://doi.org/10.1007/s10529-007-9590-4
  36. Swain, T., W. E. Hillis, and M. Oritega. 1959. Phenolic constituents of Ptunus domestica. I. Quantitative analysis of phenolic constituents. J. Sci. Food Agric. 10, 83-88.
  37. Vile, G. F. and R. M. Tyrrell. 1995. UVA radiation-induced oxidative damage to lipid and protein in vitro and in human skin fibroblast is dependent on iron and singlet oxygen. Free Radical Biol. Med. 18, 721-730. https://doi.org/10.1016/0891-5849(94)00192-M
  38. Woo, K. S., I. G. Hwang, D. S. Song, Y. R. Lee, J. S. Lee, and H. S. Jeong. 2008. Changes in antioxidant activity of Rehmannia radix Libosch with heat treatment. Food Sci. Biotechnol. 17, 1387-1390.
  39. Yang, H. J., E. H. Kim, J. O. Park, J. E. Kim, and S. N. Park. 2009. Antioxidative activity and component analysis of fermented Melissa officinalis extracts. J. Soc. Cosmet. Scientists Korea 35, 47-55.
  40. Yang, H. J., E. H. Kim, J. O. Park, J. E. Kim, and S. N. Park. 2009. Antioxidant activity and component analysis of fermented Melissa officinalis extracts. J. Soc. Cosmet. Scientists Korea 35, 125-134.
  41. Zhu, Q. V., R. M. Hackman, X. X. Jodilensunsa, R. R. Holt, and C. L. Keen. 2002. Antioxidative activities of Oolong tea. J. Agric. Food Chem. 50, 6229-6934.

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