Vegetable and fruit intake and its relevance with serum osteocalcin and urinary deoxypyridinoline in Korean adults

  • Kang, Myung-Hwa (Department of Food Science and Nutrition, Hoseo University) ;
  • Kim, Myung-Hee (Deptartment of Food and Nutrition, Kongju National University) ;
  • Bae, Yun-Jung (Department of Food and Nutrition, Sookmyung Women's University) ;
  • Choi, Mi-Kyeong (Deptartment of Food and Nutrition, Kongju National University)
  • Received : 2010.04.13
  • Accepted : 2010.05.26
  • Published : 2010.10.31


The purpose of this study was to evaluate the daily vegetable and fruit intake status of Korean adults and to examine the relationship of vegetable and fruit intake with bone metabolism. The vegetable and fruit intake of 542 healthy male and female adults was analyzed. Then, by selecting 51 targets from the subjects, the relation of vegetable and fruit intake with serum calcium, osteocalcin and deoxypyridinoline (DPD) excretion in urine was examined. The total vegetable intake per day was 397.7 g and 333.5 g by men and women respectively for the age group of 20-29, 366.9 g and 309.2 g respectively for the age group of 30-49, 378.4 g and 325.9 g respectively for the age group of 50-64. Of vegetable varieties, leafy and stem vegetables displayed the highest intake. The order of major intake items of vegetables and fruits was found to be Chinese cabbage kimchi, onion, radish, cucumber, and welsh onion for the age group of 20-29, watermelon, Chinese cabbage kimchi, peach, potato, and onion for the age group of 30-49 and watermelon, Chinese cabbage kimchi, tomato, potato, and peach for the age group of 50-64. Of 51 targets, ${\beta}$-carotene intake displayed a significantly negative correlation with serum osteocalcin. While caloric intake as well as protein, carbohydrate, calcium, phosphorous, zinc and total food intake displayed a significantly negative correlation with DPD excretion in urine, tuber vegetable intake displayed a significantly positive correlation with DPD excretion in urine. In the future, a study will be necessary to accurately explain the relevance of vegetable and fruit intake with bone mineral density and bone metabolism. Also, efforts will be required to increase vegetable and fruit intake.


Vegetables;fruits;Korean adults;osteocalcin;deoxypyridinoline


  1. Korea Center for Disease Control and Prevention, Ministry for Health, Welfare and Family Affairs. Report on 2005 national health and nutrition examination survey-Nutrition survey. Seoul: Ministry for Health, Welfare and Family Affairs; 2006.
  2. Steinmetz KA, Potter JD. Vegetables, fruit, and cancer. II. Mechanisms. Cancer Causes Control 1991;2:427-93.
  3. Hennekens CH, Mayrent SL, Willet W. Vitamin A, carotenoids and retinoids. Cancer 1986;58:1837-41.<1837::AID-CNCR2820581409>3.0.CO;2-X
  4. Ziegler RG. A review of epidemiologic evidence that carotenoids reduce the risk of cancer. J Nutr 1989;119:116-22.
  5. Choi MK, Bae YJ. A study on blood lipids and blood pressure of adult men and women according to vegetable intake. Korean Journal of Community Nutrition 2007;12:761-72.
  6. Hung HC, Joshipura KJ, Jiang R, Hu FB, Hunter D, Smith- Warmer SA, Colditz GA, Rosner B, Spiegelman D, Willett WC. Fruit and vegetable intake and risk of major chronic disease. J Natl Cancer Inst 2004;96:1577-84.
  7. Nothlings U, Schulze MB, Weikert C, Boeing H, van der Schouw YT, Bamia C, Benetou V, Lagiou P, Krogh V, Beulens JW, Peeters PH, Halkjaer J, Tjonneland A, Tumino R, Panico S, Masala G, Clavel-Chapelon F, de Lauzon B, Boutron-Ruault MC, Vercambre MN, Kaaks R, Linseisen J, Overvad K, Arriola L, Ardanaz E, Gonzalez CA, Tormo MJ, Bingham S, Khaw KT, Key TJ, Vineis P, Riboli E, Ferrari P, Boffetta P, Bueno-de- Mesquita HB, van der A DL, Berglund G, Wirfalt E, Hallmans G, Johansson I, Lund E, Trichopoulo A. Intake of vegetables, legumes, and fruit, and risk for all-cause, cardiovascular, and cancer mortality in a European diabetic population. J Nutr 2008;138:775-81.
  8. Wiseman M. The second World Cancer Research Fund/American Institute for Cancer Research expert report. Food, nutrition, physical activity, and the prevention of cancer: a global perspective. Proc Nutr Soc 2008;67:253-6.
  9. Alekel DL, Germain AS, Peterson CT, Hanson KB, Stewart JW, Toda T. Isoflavone-rich soy protein isolate attenuates bone loss in the lumbar spine of perimenopausal women. Am J Clin Nutr 2000;72:844-52.
  10. New SA, Robins SP, Campbell MK, Martin JC, Garton MJ, Bolton-Smith C, Grubb DA, Lee SJ, Reid DM. Dietary influences on bone mass and bone metabolism: further evidence of a positive link between fruit and vegetable consumption and bone health? Am J Clin Nutr 2000;71:142-51.
  11. Tucker KL, Hannan MT, Chen H, Cupples LA, Wilson PW, Kiel DP. Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women. Am J Clin Nutr 1999;69:727-36.
  12. Franceschi RT. The role of ascorbic acid in mesenchymal differentiation. Nutr Rev 1992;50:65-70.
  13. Morton DJ, Barrett-Connor EL, Schneider DL. Vitamin C supplement use and bone mineral density in postmenopausal women. J Bone Miner Res 2001;16:135-40.
  14. Kwon JH, Shim JE, Park MK, Paik HY. Evaluation of fruits and vegetables intake for prevention of chronic disease in Korean adults aged 30 years and over: using the third Korea national health and nutrition examination survey (KNHANES III); 2005. The Korean Journal of Nutrition 2009;42:146-57.
  15. Dawber TR, Meadors GF, Moore FEJ. Epidemiological approaches to heart disease: the Framingham Study. Am J Public Health Nations Health 1951;41:279-81.
  16. Tucker KL, Chen H, Hannan MT, Cupples LA, Wilson PW, Felson D, Kiel DP. Bone mineral density and dietary patterns in older adults: the Framingham Osteoporosis Study. Am J Clin Nutr 2002;76:245-52.
  17. McGartland CP, Robson PJ, Murray LJ, Cran GW, Savage MJ, Watkins DC, Rooney MM, Boreham CA. Fruit and vegetable consumption and bone mineral density: the Northern Ireland Young Heart Project. Am J Clin Nutr 2004;80:1019-23.
  18. Okubo H, Sasaki S, Horiguchi H, Oguma E, Miyamoto K, Hosoi Y, Kim MK, Kayama F. Dietary patterns associated with bone mineral density in premenopausal Japanese farmwomen. Am J Clin Nutr 2006;83:1185-92.
  19. Nordin BEC. Calcium in human biology. Heidelberg: Springer- Verlag; 1988.
  20. Brown JP, Delmas PD, Malaval L, Edouard C, Chapuy MC, Meunier PJ. Serum bone-Gla protein: a specific marker for bone formation in postmenopausal osteoporosis. Lancet 1984;1:1091-3.
  21. Liu G, Peacock M. Age-related changes in serum undercarboxylated osteocalcin and its relationships with bone density, bone quality, and hip fracture. Calcif Tissue Int 1998;62:286-9.
  22. Rubinacci A, Melzi R, Zampino M, Soldarini A, Villa I. Total and free deoxypyridinoline after acute osteoclast activity inhibition. Clin Chem 1999;45:1510-6.
  23. Kleerekoper M. Biochemical markers of bone remodeling. Am J Med Sci 1996;312:270-7.

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