Randomized Clinical Controlled Trials of a Herb Remedies in Korea - Systematic Review

한약을 이용한 한국에서의 무작위 임상시험 개괄적 검토

  • Oh, Rai-Young (Institute of traditional Medicine and Bioscience, Daejeon University) ;
  • Seol, In-Chan (Strock Center, Daejeon Oriental Hospital, Daejeon University) ;
  • Son, Chang-Gue (Liver and Immunology Research Center, Daejeon Oriental Hospital, Daejeon University)
  • 오래영 (대전대학교 동서생명과학연구원) ;
  • 설인찬 (대전대학교 한의과대학 중풍센터) ;
  • 손창규 (대전대학교 한의과대학 간장.면역센터)
  • Received : 2010.02.01
  • Accepted : 2010.05.26
  • Published : 2010.07.31

Abstract

Objective: The study aimed to review all randomized controlled clinical trials (RCTs) performed in Korea with herbal medicine, to produce further useful information for herbal-drug development. Methods: All papers reporting RCT with herbal drugs were collected via public database of Korea Science and Technology Integration Services, and various Oriental medicine journals. Then, the clinical question, herbal medicine, result, RCT design, and its conductor were analyzed. Results: A total of 20 RCTs were finally selected, and most of them were performed after 2003. The main subjects of RCT were related to heart and blood circulation, dermatitis, respiration disorder, Sasang constitution, or psychiatric disorders. Eight RCTs were done with a single herb while 12 RCTs were with multiple herbal formulae. In particular, three RCTs for atopic dermatitis with three formulae showed positive results. The quality of RCT was considered as better than average. Conclusions: This study revealed the current status of RCT using herbal drugs. This result would provide helpful information for research and drug development using traditional herbal medicine.

Acknowledgement

Supported by : 보건복지부

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