- Volume 20 Issue 2
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Effect of Sulforaphane on LPS-Induced Matrix Metalloproteinase-9 (MMP-9) Expression
Sulfolaphane이 lipopolysaccharide (LPS)에 의해 유도된 matrix metalloproteinase-9 (MMP-9) 발현에 미치는 영향
- Lee, Jung-Tae (Department of Immunology, School of Medicine, Keimyung University) ;
- Woo, Kyung-Jin (Department of Immunology, School of Medicine, Keimyung University) ;
- Kwon, Taeg-Kyu (Department of Immunology, School of Medicine, Keimyung University)
- Received : 2010.01.05
- Accepted : 2010.02.22
- Published : 2010.02.28
Sulforaphane is a naturally occurring member of the iosothiocyanate family, which reveals chemopreventive capacities including anti-cancer, anti-inflammation and inhibition of MMP-9 activities. In this study, we investigated the effect of sulforaphane on the expression of matrix metalloproteinase-9 (MMP-9) in lipopolysaccharide (LPS)-induced Raw 264.7 cells. Sulforaphane strikingly suppressed the LPS-induced MMP-9 activity and mRNA expression in a dose-dependent manner. In addition, sulforaphane inhibited not only the LPS-induced MMP-9 promoter activity but also LPS-mediated activator protein-1 (AP-1) and nuclear factor-kB (NF-
Supported by : 한국과학재단
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