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Effects of Aged Black Garlic Extract on Ethanol Induced Hangover in Rats

흑마늘 추출물이 알코올을 투여한 흰쥐에 미치는 영향

  • Yang, Seung-Taek (Department of Food Science and Biotechnology, Kyungsung University)
  • 양승택 (경성대학교 식품생명공학과)
  • Received : 2009.11.24
  • Accepted : 2010.01.14
  • Published : 2010.02.28

Abstract

This study was proposed to investigate the effects of water extract of aged black garlic on ethanol induced hangovers in rats. Male Sprague-Dawley rats weighing $180{\pm}10\;g$ were divided into the following three groups; control, 130 mg/kg, and 260 mg/kg of aged black garlic extract. Aged black garlic was administered orally 30 min before and 30 min after ingestion of 40% ethanol (5 g/kg, B.W.). The rats were killed 24 hr after ethanol treatment, and blood was taken from the caudal artery at 1, 3, and 5 hr to test for ethanol or acetaldehyde in the serum. Groups that were administered aged black garlic extract pre- and post-alcohol consumption showed a significant decrease in ethanol levels in the blood at 1, 3, and 5 hr. The acetaldehyde concentrations decreased in both 130 mg/kg and 260 mg/kg groups that were administered aged black garlic extract pre- and post-alcohol consumption. The activities of alcohol dehydrogenase seemed to be unaffected, although the aged black garlic showed slightly higher activities of acetaldehyde dehydrogenase in pre- or post-alcohol consumption. The aspartate aminotransferase (AST) activity in the serum, elevated by ethanol, was decreased by administering a high dosage of aged black garlic extract, but resulted in no significant change in serum alanine aminotransferase (ALT) activity. These results concluded that aged black garlic extract can reduce hangover syndrome through the elevation of ALDH.

Acknowledgement

Supported by : 경성대학교

References

  1. Bergmeyer, H. U. 1974. Methods of enzymatic analysis. pp. 28-35, Academic Press. New York.
  2. Bucher, T. and H. Redetxki. 1951. Eine spezifische photometrische bestimmung von athylakohol auf fermentativen wege. Klin. Wochenschr. 29, 615-618. https://doi.org/10.1007/BF01485653
  3. Cho, M. H., J. J. Lee, and M. Y. Lee. 2007. Effect of pimpinela ethanol extract on chronically ethanol-induced liver damage in rats. J. Life Sci. 17, 1406-1413. https://doi.org/10.5352/JLS.2007.17.10.1406
  4. Cho, S. H., J. C. Kim, and S. W. Kim. 2001. Effect of plant extracts on the activity of alcohol dehydrogenase and the antioxidation in alcohol-treated rat hepatocyte. J. Korean Soc. Food Sci. Nutr. 30, 679-683.
  5. Cristol, L., S. I. Jialal, and M. Grundy. 1992. Effect of low dose probucol therapyon LDL oxidation and the plasma lipoprotein profile in male volunteers. Atherosclerosis 97, 11-20. https://doi.org/10.1016/0021-9150(92)90046-J
  6. Forsander, O. A. and C. R. Niels. 1960. Metabolites produced in the liver during alcohol oxidation. J. Biol. Chem. 235, 34-36.
  7. Glueck, C. J., E. Hogg, C. Allen, and P. S. Gartside. 1980. Effects of alcohol ingestion on lipid and lipoprotein in normal man. Am. J. Clin. Nutr. 33, 2287-2293.
  8. Goldstein, J. L., Y. K. Ho, S. K. Basu, and M. S. Brown. 1979. Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition. Proc. Nat. Acad. Sci. USA 76, 333-337. https://doi.org/10.1073/pnas.76.1.333
  9. Heineckem, J. W. 1987. Free radical modification of low-density lipoprotein: Mechanisms and biological consequences. Free Rad. Biol. Med. 3, 65-73. https://doi.org/10.1016/0891-5849(87)90040-2
  10. Hwang, J. Y., J. W. Ham, and S. H. Nam. 2004. Effect of maesil (prunus mume) juice on the alcohol metabolizing enzyme activities. Korean J. Food Sci. Technol. 36, 329-332.
  11. Jernigan, T. L. and A. L. Osterguard. 1995. When alcoholism affects memory functions.: MRI of the brain. Alcohol Health Res. World 19, 104-107.
  12. Kato, S., T. Kawase, J. Alderman, N. Inatomi, and C. S. Liber. 1990. Role of xanthine oxidase in ethanol-induced lipid peroxidation in rat. Gastroenterol. 98, 203-209.
  13. Kim, J. S. 2004. Effect of a alcohol detoxification beverage contained radix puerariae and bambusae caules in liquamen phyllostachyos on the alcohol administered mouse. J. Korean Soc. Food Sci. Nutr. 33, 318-323. https://doi.org/10.3746/jkfn.2004.33.2.318
  14. Kodea, Y., A. Suzuki, S. Kasuga, I. Sumioka, A. Kanezawa, M. Fujikawa, S. Nagae, and K. Masamoto. 2002. Physical, chemical, and biological properties of S-allylcysteine, an amino acid derived from garlic. J. Agric. Food Chem. 50, 622-632. https://doi.org/10.1021/jf0106648
  15. Koivula, T. and M. Koivusalo. 1975. Different form of rat liver aldehyde dehydrogenase and their subcellular distribution. Biochem. Biophs. ACTA 397, 9-15. https://doi.org/10.1016/0005-2744(75)90174-6
  16. Lieber, C. S. 1994. Alcohol and liver. Gastroenterology 106, 1085-1090.
  17. Lieber, C. S. 1997. Ethanol metabolism, cirrhosis and alcoholism. Clin. Chim. ACTA 257, 59-84. https://doi.org/10.1016/S0009-8981(96)06434-0
  18. Lowry, O. H, N. J. Rosebrough, A. L. Farr, and R. J. Randall. 1951. Protein measurement with folin phenol reagent. J. Biol. Chem. 193, 265-271.
  19. Mezey, E. 1980. Alcoholic liver disease; Roles of alcohol and malnutrition. Am. J. Clin. Nutr. 33, 2709-2718.
  20. Moore, G. S. and R. D. Atkins. 1997. The fungicidal and fungicidal effects of aqueous garlic extract on medically important yeast fungi. Mycologia 69, 341-348. https://doi.org/10.2307/3758659
  21. Morel, D. W., P. E. DiCorleto, and G. M. Chisholm. 1984. Endothelial and smooth muscle cells after low density lipoproteins in vitro by free radical oxidation. Arteriosclerosis 4, 357-364. https://doi.org/10.1161/01.ATV.4.4.357
  22. Noh, K. H., J. H. Jang, J. J. Kim, J. H. Shin, D. K. Kim, and Y. S. Song. 2009. Effect of dandelion juice supplementation on alcohol-induced oxidative stress and hangover in healthy male college students. J. Korean Soc. Food Sci. Nutr. 38, 683-693. https://doi.org/10.3746/jkfn.2009.38.6.683
  23. Park, E. M., E. J. Ye, S. J. Kim, H. I. Choi, and M. J. Bae. 2006. Eliminatory effect of health drink containing hovenia dulcis thumb extract on ethanol-induced hangover in rats. Korean J. Food Culture 21, 71-75.
  24. Reitman, S. and S. Frankel. 1957. A colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminase. Am. J. Clin. Pathol. 28, 8-15.
  25. Yang, S. T. 2007. Antioxidative activity of extracts of aged black garlic on oxidation of human low density lipoprotein. J. Life Sci. 17, 1330-1335. https://doi.org/10.5352/JLS.2007.17.10.1330
  26. Yang, S. T. 2008. Antioxidative effect of sulfur containing compounds in garlic on oxidation of human low density lipoprotein induced by macrophages and copperion. J. Life Sci. 18. 9-15. https://doi.org/10.5352/JLS.2008.18.1.009

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