Comparison of Functional Constituents and Biological Activity of the Seed Extracts from Two Mulberry Fruits

  • Kim, Eun-Ok (Department of Food Science and Nutrition, Catholic University of Daegu) ;
  • Yu, Myeong-Hwa (Department of Food Science and Nutrition, Catholic University of Daegu) ;
  • Lee, Yu-Jin (Department of Food Science and Nutrition, Catholic University of Daegu) ;
  • Leem, Hyun-Hee (Department of Food Science and Nutrition, Catholic University of Daegu) ;
  • Kim, Shin-Ae (Department of Industrial Channel Management, Gongju National University) ;
  • Kang, Dae-Hun (Sangro Co., Ltd.) ;
  • Choi, Sang-Won (Department of Food Science and Nutrition, Catholic University of Daegu)
  • 투고 : 2010.03.29
  • 심사 : 2010.06.11
  • 발행 : 2010.06.30


The seeds from two mulberry fruits [Morus alba (MA) and Cudrania tricuspidata (CT)] were examined for their oil content, and fatty acid, phytosterol and tocopherol compositions and contents. Moreover, polyphenolic compounds and biological activity of the two defatted seed residue extracts were also evaluated. Oil contents of MA and CT seeds were 29.36% and 16.69%, respectively, while MeOH extracts of the defatted MA and CT seed residues were 5.10% and 6.22%, respectively. The two seed oils were composed of 81.4 and 74.37% linoleic, 5.75 and 11.39% oleic, 8.40 and 10.18% palmitic acid, and 3.52 and 3.0% stearic acids, and two other minor fatty acids, such as linolenic and arachidic acids. MA seed had higher contents of phytosterols (507.59 mg/100 g of oil), tocopherols (99.64 mg/100 g of oil), and total flavonoid (106.50 mg/100 g of seed) than CT seed, whereas CT seed had higher levels of total polyphenol than MA seed. The MeOH extract of MA seed residue showed higher antioxidant, anti-diabetic, and anti-melanogenic activity than that of CT seed residue. trans-Resveratrol (9.62 mg/100 g), quercetin (54.83 mg/100 g), and 4-prenylmoracin (48.70 mg/100 g), were found to be the main polyphenolic components in the MeOH extract of MA seed residue. These results indicate that MA seeds are good sources of essential dietary phytochemicals with antioxidant, anti-diabetic and anti-melanogenic activity.


연구 과제 주관 기관 : Ministry of Agriculture, Forestry, and Fisheries


  1. Hasler CM. 1998. Functional foods: Their role in disease prevention and health promotion. Food Technol 52: 63-70.
  2. Kim HK. 2004. Current status and prospect of nutraceuticals.Food Indus Nutr 9: 1-14.
  3. Gonzalez-Paramas AM, Esteban-Ruano S, Santos-BuelgaC, Pascual-Teresa S, Rivas-Gonzalo JC. 2004. Flavanol content and antioxidant activity in winery byproducts. J Agric Food Chem 52: 234-238.
  4. Shrikhande AJ. 2000. Wine byproducts with health benefits.Food Res Int 33: 469-474.
  5. Parry J, Su L, Moore J, Cheng Z, Luther M, Rao JN, WangJY, Yu LL. 2006. Chemical composition, antioxidant capacities, and antiproliferative activities of selected fruit seed flours. J Agric Food Chem 54: 3773-3778.
  6. Maier T, Schieber A, Kammerer DR, Carle R. 2009.Residues of grape (Vitis vinifera L.) seed oil production as a valuable source of phenolic antioxidants. Food Chem 112: 551-559.
  7. Bakowska-Barczak AM, Schieber A, Kolodziejczyk P.2009. Characterization of Canadian black currant (Ribes nigrum L.) seed oils and residues. J Agric Food Chem 57: 11528-11536.
  8. Kim HJ, Cha JY, Choi ML, Cho YS. 2000. Antioxidative activities by water-soluble extracts of Morus alba and Cudrania tricuspidata. J Korean Soc Agric Chem Biotechnol43: 148-152.

피인용 문헌

  1. Antioxidant Activities and Quality Characteristics of Mulberry Concentrate, Freeze-dried Mulberry, and Pomace vol.41, pp.10, 2012,
  2. Isolation and Identification of Antioxidant Polyphenolic Compounds in Mulberry (Morus alba L.) Seeds vol.40, pp.4, 2011,
  3. Melanogenesis Inhibitory Activities of Mulberry Seed Ethanol Extracts vol.41, pp.3, 2015,