Immunohistochemical Expression of Caspase 3 and Its Relationship with p53 Expression in Endometrial Cancers

  • Lee, Kyung-Enn (Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan)
  • 이경은 (부산가톨릭대학교 임상병리학과)
  • Received : 2010.10.21
  • Accepted : 2010.12.10
  • Published : 2010.12.31

Abstract

Apoptosis is an important significance in the pathogenesis of cancer. Caspase 3 and p53 have been identified as important members of the apoptosis related proteins. This study was performed to define roles of caspase 3 expression and its relationship with p53 expression in endometrial cancers by immunohistochemistry. Immunoreactivity for caspase 3 was found in 13 (65.0%) out of 20 endometrial hyperplasia cases and 8 (36.4%) out of 22 endometrial cancers. Seven (87.5%) of the 8 cases with a positive caspase 3 immunoreactivity showed a positive p53 expression in 22 endometrial cancers. There were no significant associations between caspase 3 and p53 expressions. These findings suggest that caspase 3 expression might be associated with carcinogenesis of endometrial cancers. Further studies are needed to define the relationship between caspase 3 and p53 and apoptosis for examining the mechanisms of tissue-specific apoptosis related protein.

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