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Effects of a soluble dietary fibre NUTRIOSE$^{(R)}$ on colonic fermentation and excretion rates in rats

  • Guerin-Deremaux, Laetitia ;
  • Ringard, Florence ;
  • Desailly, Fabrice ;
  • Wils, Daniel
  • Received : 2010.05.12
  • Accepted : 2010.10.21
  • Published : 2010.12.31

Abstract

The resistant dextrin NUTRIOSE$^{(R)}$, developed from starch, is expected to act as a prebiotic. The aim of this study was to determine the effects of NUTRIOSE$^{(R)}$ on cecal parameters, short-chain fatty acid (SCFA) concentrations, and fecal excretion in rats. In an initial experiment, twenty-four male Fischer F344 rats were randomly assigned to one of the following four treatments for 14 days: G0 (control diet), G2.5 (control diet+2.5% of dextrin), G5 (control diet + 5% of dextrin), and G10 (control diet + 10% of dextrin). After 14 days, total cecal weight, cecal content, and cecal wall weight were significantly increased in G5 and G10 compared to G0. At the same time, cecal pH was significantly lower in G10 compared to G0. Total SCFA concentration was significantly higher in G10 than in G5, G2.5, and G0, and significantly higher in G5 than in G0. Acetate, butyrate, and propionate concentrations were significantly increased in G5 and G10 compared to the controls. In a second trial based on a similar design, eighteen male Fischer F344 rats were treated with a control diet supplemented with 5% of dextrin or 5% of fructo-oligosaccharide. The results obtained with NUTRIOSE$^{(R)}$ were similar to those obtained with the fructo-oligosaccharide. In a third experiment, two groups of 5 Fischer F344 rats were orally treated with 100 and 1,000 mg/kg NUTRIOSE$^{(R)}$, respectively, and from 18% to 25% of the dextrin was excreted in the feces. The results of these three studies show that the consumption of NUTRIOSE$^{(R)}$, by its effects on total cecal weight, cecal content, cecal wall weight, pH, and SCFA production, could induce healthy benefits since these effects are reported to be prebiotic effects.

Keywords

Colonic fermentation;short chain fatty acid;caecum;dietary fibre;dextrin

References

  1. Gibson GR, Probelt HM, Loo lV, Rastall RA, Roberfroid ME. Dietary modulation of the human colonic microbiota: updating the concept of prebiotics. Nutr Res Rev 2004; 17:259-275. https://doi.org/10.1079/NRR200479
  2. Bornet FR. Undigestible sugars in food products. Am J Clin Nutr 1994;59:763S-769S.
  3. Duggan C, Gannon J, Walker WA. Protective nutrients arId functional foods for the gastrointestinal tract. Am J Clin Nutr 2002;75:789-808.
  4. Kritchevsky D. Dietary fiber. Annu Rev Nutr 1988;8:301-328. https://doi.org/10.1146/annurev.nu.08.070188.001505
  5. Geier MS, Butler RN, Howarth GS. Probiotics, prebiotics and synbiotics: a role in chemoprevention for colorectal CarIcer? Cancer Bioi Ther 2006;5:1265-1269.
  6. Prosky L; AOAC International. Committee on Food Nutrition. Dietary fiber. J AOAC lnt 2001;84:222-224
  7. Anderson JW, Bridges SR. Short-chain fatty acid fermentation products of plant fiber affect glucose metabolism of isolated rat hepatocytes. Proc Soc Exp BioI Med 1984;177:372-376.
  8. Berggren AM, Bjiirck 1M, Nyman EM, Eggum BO. Short-chain fatty acid content and pH in caecum of rats given various sources of carbohydrates. J Sci Food Agric 1993;63:397-406. https://doi.org/10.1002/jsfa.2740630405
  9. May T, Mackie Rl, Fahey GC Jr, Cremin JC, Garleb KA. Effect of fiber source on short-chain fatty acid production and on the growth arId toxin production by Clostridium difficile. Scand J Gastroenterol 1994;29:916-922. https://doi.org/10.3109/00365529409094863
  10. Boillot J, Alamowitch C, Berger AM, Luo J, Bmzzo F, Bomet FR, Slama G. Effects of dietary propionate Oil hepatic glucose production, whole-body glucose utilization, carbohydrate and lipid metabolism in normal rats. Br J Nutr 1995;73:241-251. https://doi.org/10.1079/BJN19950026
  11. Cummings JH, Macfarlane GT, Englyst fIN. Prebiotic digestion and fennentation. Am J Clin Nutr 2001;73:415S-420S.
  12. Demigne C, Remesy C, Rayssiguier Y. Effect of fermentable carbohydrates on volatile fatty acids, ammonia arId mineral absorption in the rat caecum. Reprod Nutr Dev 1980;20:1351-1359. https://doi.org/10.1051/rnd:19800726
  13. Campbell 1M, Fahey GC Jr, Wolf BW. Selected indigestible oligosaccharides affect large bowel mass, cecal arId fecal short-chain fatty acids, pH arId microflora in rats. J Nutr 1997; 127:130-136.
  14. Djouzi Z, Andrieux C. Compared effects of three oligosaccharides on metabolism of intestinal microl1ora in rats inoculated with a human faecal flora. Br J Nutr 1997;78:313-324. https://doi.org/10.1079/BJN19970149
  15. Levrat MA, Remesy C, Demigne C. High propionic acid fermentations arId mineral accumulation in the cecum of rats adapted to different levels of inulin. J Nutr 1991; 121:1730-1737.
  16. Roberfroid MB. Concepts in functional foods: the case of inulin arId oligofmctose. J Nutr 1999;129: 1398S-1401S.
  17. Roberfroid M. Dietary fiber, inulin, and oligofmctose: a review comparing their physiological effects. Crit Rev Food Sci Nutr 1993;33:103-148. https://doi.org/10.1080/10408399309527616
  18. Roberfroid MB. lIealth benefits of non-digestible oligosaccharides. Adv Exp Med BioI 1997;427:211-219. https://doi.org/10.1007/978-1-4615-5967-2_22
  19. van den Heuvel EG, Wils D, PasmarI WJ, Bakker M, Saniez MR, Kardinaal AF. Short-term digestive tolerance of different doses of NUTRIOSE FB, a food dextrin, in adult men. Eur J Clin Nutr 2004;58:1046-1055. https://doi.org/10.1038/sj.ejcn.1601930
  20. Gibson GR, Beatty ER, Wang X, Cummings JH. Selective stimulation of bifidobacteria in the human colon by oligofructose arId inulin. Gastroenterology 1995;108:975-982. https://doi.org/10.1016/0016-5085(95)90192-2
  21. van den Heuvcl EG, Wils D, Pasman WJ, Sanicz Mil, Kardinaal AF. Dietary supplementation of different doses of NUTRIOSE FB, a fernlcntable dextrin, alters the activity of faecal enzymes in healthy men. Em J Nutr 2005;44:445-451. https://doi.org/10.1007/s00394-005-0552-0
  22. Todesco T, Rao AV, Bosello 0, Jenkins DJ. Propionate lowers blood glucose and alters lipid metabolism in healthy subjects. Am J CIin Nutr 1991;54:860-865.
  23. Propst EL, Flickinger EA, Bauer LL, Merchen NR, Fahey GC Jr. A dose-response experiment evaluating the effects of oligofmctose and inulin on nutrient digestibility, stool quality, and fecal protein catabolites in healthy adult dogs. J Anim Sci 2003;81:3057-3066.
  24. Smiricky-Tjardes MR, Glieshop CM, Flickinger EA, Bauer LL, Fahey GC Jr. Dietary galactooligosaccharides affect ileal and total-tract nutrient digestibility, ileal and fecal bacterial concentrations, and ileal felTI1entative characteristics of growing pigs. J Anim Sci 2003;81:2535-2545.
  25. Wong 1M, de Souza R, Kendall CW, Emam A, Jenkins DJ. Colonic health: felTI1entation and short chain fatty acids. J Clin Gastroenterol 2006;40:235-243. https://doi.org/10.1097/00004836-200603000-00015
  26. Gibson GR, Roberfroid MB. Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J Nutr 1995;125:1401-1412.
  27. VelTI10rel M, Coudray C, Wils D, Sinaud S, Tressol JC, Montaurier C, Vemet J, Brandolini M, Bouteloup-Demange C, Rayssiguier Y. Energy value of a low-digestible carbohydrate, NUTRIOSE FB, and its impact on magnesium, calcium and zinc apparent absorption and retention in healthy young men. Eur J Nutr 2004;43:344-352. https://doi.org/10.1007/s00394-004-0477-z
  28. Scholz-Ahrens KE, Ade P, Marten B, Weber P, Timm W, Acil Y, Gllier CC, Schrezenmeir J. Prebiotics, probiotics, and synbiotics affect mineral absorption, bone mineral content, and bone structure. J Nutr 2007;137:838S-846S.
  29. Hoyles L, Vulevic J. Diet, immunity and functional foods. Adv Exp Med Biol 2008;635:79-92.
  30. Lefranc-Millot C. NUTRlOSE® 06: a useful soluble dietary fibre for added nutritional value. Nutrition Bulletin 2008;33:234-239. https://doi.org/10.1111/j.1467-3010.2008.00711.x
  31. Pasman W, Wils D, Saniez MR, Kardinaal A. Long-telm gastrointestinal tolerance of NUTRlOSE FB in healthy men. Eur J Clin Nutr 2006;60:1024-1034. https://doi.org/10.1038/sj.ejcn.1602418

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