Effects of Eucommia ulmodies Oliver Tea Extract on aluminum Accumulation Rate and Tissue Function in Aluminum-administered Rats

두충차 추출액이 알루미늄 투여 흰쥐의 알루미늄 축적률과 각종 장기 기능에 미치는 영향

  • Han, Sung-Hee (Department of Food & Nutrition, Wonkwang Health Science Unuversity)
  • 한성희 (원광보건대학 식품영양학과)
  • Received : 2010.07.26
  • Accepted : 2010.11.04
  • Published : 2010.12.31

Abstract

This study was designed to investigate the effects of Korean Eucommia ulmodies Oliver tea extract on aluminum administered rats. Forty-eight male Sprague-Dawley rats (100${\pm}$10 g) were divided into the following six groups; control group, 3% E. ulmodies tea extract group, 1,000 and 2,000 ppm aluminum ($Al_2(SO_4)_3$ in distilled water) groups, and 1,000 and 2,000 ppm aluminum plus 3% E. ulmodies tea extract groups. The aluminum content in the rat tissues of the aluminum administered group was lower than that in the rat tissue of the aluminum group administered 3% E. ulmodies tea extract. Asparate aminotransferase and alanine aminotransferase levels increased in the aluminum-administered group but were lower in the 3% E. ulmodies tea extract group. Lactate dehydrogenase was lower in the 3% extract E. ulmodies teaaluminum group than that in the aluminum group. Cholinesterase was higher in the 3% E. ulmodies tea-aluminum group than that in the aluminum group. Plasma renin activity levels increased in the aluminum administration group, compared with the aluminum plus 3% E. ulmodies tea group. Plasma aldosterone levels increased in the aluminum administration group compared with the aluminum plus 3% E. ulmodies tea group. These results suggest that an extract of E. ulmodies tea in water has lowering effects on the accumulation of aluminum. It is believed that the E. ulmodies tea had some protective effects in the aluminum-administered rats, but the mechanisms remain obscure.

Acknowledgement

Supported by : 원광보건대학

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