Estimation on the Depth of Anesthesia using Linear and Nonlinear Analysis of HRV

HRV 신호의 선형 및 비선형 분석을 이용한 마취심도 평가

  • 예수영 (부산대학교 BK21 고급의료인력양성사업단) ;
  • 백승완 (부산대학교 마취통증의학교실) ;
  • 김혜진 (부산대학교 마취통증의학교실) ;
  • 김태균 (부산대학교 마취통증의학교실) ;
  • 전계록 (부산대학교 의공학교실)
  • Published : 2010.01.01


In general, anesthetic depth is evaluated by experience of anesthesiologist based on the changes of blood pressure and pulse rate. So it is difficult to guarantee the accuracy in evaluation of anesthetic depth. The efforts to develop the objective index for evaluation of anesthetic depth were continued but there was few progression in this area. Heart rate variability provides much information of autonomic activity of cardiovascular system and almost all anesthetics depress the autonomic activity. Novel monitoring system which can simply and exactly analyze the autonomic activity of cardiovascular system will provide important information for evaluation of anesthetic depth. We investigated the anesthetic depth as following 7 stages. These are pre-anesthesia, induction, skin incision, before extubation, after extubation, Post-anesthesia. In this study, temporal, frequency and chaos analysis method were used to analyze the HRV time series from electrocardiogram signal. There were NN10-NN50, mean, SDNN and RMS parameter in the temporal method. In the frequency method, there are LF and HF and LF/HF ratio, 1/f noise, alphal and alpha2 of DFA analysis parameter. In the chaos analysis, there are CD, entropy and LPE. Chaos analysis method was valuable to estimate the anesthetic depth compared with temporal and frequency method. Because human body was involved the choastic character.


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