DOI QR코드

DOI QR Code

Effects of Supplemental Recombinant Bovine Somatotropin (rbST) and Cooling with Misters and Fans on Renal Function in Relation to Regulation of Body Fluids in Different Stages of Lactation in Crossbred Holstein Cattle

  • Boonsanit, D. ;
  • Chanpongsang, S. ;
  • Chaiyabutr, N.
  • Received : 2009.05.04
  • Accepted : 2009.10.06
  • Published : 2010.03.01

Abstract

The aim of this study was to investigate the effect of supplemental recombinant bovine somatotropin (rbST) and cooling with misters and fans on renal function in relation to regulation of body fluids in different stages of lactation in crossbred Holstein cattle. Ten, 87.5% crossbred Holstein cattle were divided into two groups of 5 animals each, housing in a normal shaded barn (NS) and in a shaded barn with a mister-fans cooling system (MF). The experiment in each group was divided into 3 phases, early- (Day 75 postpartum), mid- (Day 135 postpartum), and late stage of lactation (Day 195 postpartum). The pre-treatment study was conducted on the starting day of each stage of lactation and the treatment study was performed after the end of the pre-treatment, during which the animal was injected with 500 mg of rbST (POSILAC) every 14 days for three times. During the study, ambient temperature at the hottest period daily in the MF barn was significantly lower, while relative humidity was higher than that of the NS barn. The temperature humidity index (THI) in both barns ranged from 79-85 throughout the periods of study. Cows in the MF barn showed a lower rectal temperature and respiration rate as compared with cows in the NS barn. The effect of rbST administration increased both rectal temperature and respiration rates of cows housed in either the NS or MF barn. Milk yield significantly increased in cows treated with rbST in all stages of lactation. Increases in mammary blood flow, accompanied by increases of total body water (TBW), extracellular fluid (ECF), blood volume (BV) and plasma volume (PV), were observed in both groups of cows receiving rbST in all stages of lactation. No alterations of renal blood flow and glomerular filtration rate were observed in cows receiving rbST, but decreases in urinary excretion and fractional excretion of sodium, potassium and chloride ions appeared to correlate with reduction in the rate of urine flow and osmolar clearance during rbST administration. These results suggest that the effect of rbST supplementation to cows housed either in NS or MF barns on body fluid volume expansion is attributable to changes in the rate of electrolyte excretion by the kidney. The increased availability of renal tubular reabsorption of sodium, potassium and chloride ions during rbST treatment was a major factor in retaining body water through its colligative properties in exerting formation of an osmotic force mechanism.

Keywords

Renal Function;rbST;Mister-fans Cooling;Body Fluids;Crossbred Holstein Cattle

References

  1. Bauman, D. E. 1992. Bovine somatotropin: review of an emerging animal technology. J. Dairy Sci. 75:3432-3451 https://doi.org/10.3168/jds.S0022-0302(92)78119-3
  2. Chaiyabutr, N., S. Thammacharoen, S. Komolvanich and S. Chanpongsang. 2005. Effects of long-term administration of recombinant bovine somatotropin on milk production and plasma insulin-like growth factor and insulin in crossbred Holstein cows. J. Agric. Sci. (Camb.) 143:311-318 https://doi.org/10.1017/S0021859605005538
  3. Chan, S. C., J. T. Huber, K. H. Chen, J. M. Simas and Z. Wu. 1997. Effects of ruminally inert fat and evaporative cooling on dairy cows in hot environmental temperatures. J. Dairy Sci. 80: 1172-1178 https://doi.org/10.3168/jds.S0022-0302(97)76044-2
  4. Dimke, H., A. Flyvbjerg, S. Bourgeois, K. Thomsen, J. Frokiaer, P. Houillier, S. Nielsen and S. Frische. 2007. Acute growth hormone administration induces antidiuretic and antinatriuretic effects and increases phosphorylation of NKCC2. Am. J. Physiol. Renal Physiol. 292:F723-F735
  5. Fike, J. H., C. R. Staples, L. E. Sollenberger, J. E. Moore and H. H. Head. 2002. Southeastern pasture-based dairy systems: housing, posilac, and supplemental silage effects on cow performance. J. Dairy Sci. 85:866-878 https://doi.org/10.3168/jds.S0022-0302(02)74145-3
  6. Hirschberg, R., G. Brunori, J. D. Kopper and H. P. Guler. 1993. Effects of insulin-like growth factor I on renal function in normal men. Kidney Int. 43(2):387-397 https://doi.org/10.1038/ki.1993.57
  7. Hoffman, D. M., L. Crampton, C. Sernia, T. V. Nquyen and K. K. Ho. 1996. Short-term growth hormone (GH) treatment of GHdeficient adults increases body sodium and extracellular water, but not blood pressure. J. Clin. Endocrinol. Metab. 81(3):1123-1128 https://doi.org/10.1210/jc.81.3.1123
  8. Inishi, Y., T. Katoh, T. Okuda, T. Yamaquchi and K. Kurokawa. 1997. Modulation of renal hemodynamics by IGF-I is absent in spontaneously hypertensive rats. Kidney Int. 52(1):165-170 https://doi.org/10.1038/ki.1997.316
  9. MacFarlane, W. V., R. J. H. Morris, B. Howard and O. G. Budtz-Olsen. 1959. Extracellular fluid distribution in tropical Merino sheep. Aust. J. Agric. Res. 10:269-286 https://doi.org/10.1071/AR9590268
  10. Marksiri, W., S. Chanpongsang and N. Chaiyabutr. 2005. Relationship of early lactation and bovine somatotropin to water metabolism and mammary circulation of crossbred Holstein cattle. Asian-Aust. J. Anim. Sci. 18:1600-1608
  11. West, J. W. 1994. Interactions of energy and bovine somatotropin with heat stress. J. Dairy. Sci. 71:2091-2102
  12. Cuneo, R. C., F. Salomon, P. Wilmshurst, C. Byrne, C. M. Wiles, R. Hesp and P. H. Sonksen. 1991. Cardiovascular effects of growth hormone treatment in growth-hormone-deficient adults: stimulation of the rennin-aldosterone system. Clin. Sci. (Lond). 81(5):587-592
  13. Davis, S. R., R. J. Collier, J. P. McNamara, H. H. Head and W. Sussman. 1988. Effects of thyroxine and growth hormone treatment of dairy cows on milk yield, cardiac output and mammary blood flow. J. Anim. Sci. 66(1):70-79
  14. Hanukoglu, A., O. Belutserkovsky and M. Phillip. 2001. Growth hormone activates renin-aldosterone system in children with idiopathic short stature and in a pseudohypoaldosteronism patient with a mutation in epithelial sodium channel alpha subunit. J. Steroid Biochem. Mol. Biol. 77:49-57 https://doi.org/10.1016/S0960-0760(01)00028-0
  15. Staples, C. R., H. H. Head and D. E. Daden. 1988. Short-term administration of bovine somatotropin to lactating dairy cows in a subtropical environment. J. Dairy Sci. 71:3274-3282 https://doi.org/10.3168/jds.S0022-0302(88)79932-4
  16. Medway, W. and M. R. Kare. 1959. Thiocyanate space in growing domestic fowl. Am. J. Physiol. 196:873-875
  17. Chaiyabutr, N., S. Thammacharoen, S. Komolvanich and S. Chanpongsang. 2007. Effects of long-term exogenous bovine somatotropin on water metabolism and milk yield in crossbred Holstein cattle. J. Agric. Sci. 145:173-184 https://doi.org/10.1017/S002185960700679X
  18. Prosser, C. G., I. R. Fleet, A. N. Corps, E. R. Froesch and R. B. Heap. 1990. Increase in milk secretion and mammary blood flow by intra-arterial infusion of insulin like growth factor-I into the mammary gland of the goat. J. Endocrinol. 135:311-316 https://doi.org/10.1677/joe.0.1350311
  19. Jaffa, A. A., D. LeRoith, C. T. Roberts, Jr., P. F. Rust and R. K. Mayfield. 1994. Insulin-like growth factor I produces renal hyperfiltration by a kinin-mediated mechanism. Am. J. Physiol. 266:102-107
  20. Wyse, B., M. Waters and C. Sernia. 1993. Stimulation of the rennin-angiotensin system by growth hormone in Lewis dwarf rats. Am. J. Physiol. 265:E332-E339
  21. Chaiyabutr, N., A. Faulkner and M. Peaker. 1980. Effects of starvation on the cardiovascular system, water balance and milk secretion in lactating goats. Res. Vet. Sci. 28:291-295
  22. Hart, I. C., S. E. Lawrence and T. B. Mepham. 1980. Effect of exogenous growth hormone on mammary blood flow and milk yield in lactating goats. J. Physiol. 308:46
  23. AOAC. 1990. Official methods of analysis. 4th edn. Association of Official Analytical Chemists, Washington, DC
  24. Cole, J. A. and P. J. Hansen. 1993. Effects of administration of recombinant bovine somatotropin on the responses of lactating and non-lactating cows to heat stress. J. Am. Vet. Med. Assoc. 203:113-117
  25. Herlitz, H., O. Jonsson and B. A. Bengtsson. 1994. Effect of recombinant human growth hormone on cellular sodium metabolism. Clin. Sci. (Lond). 86(3):233-237
  26. Moller, J., J. O. Jorgensen, E. Frandsen, T. Laursen and J. S. Christiansen. 1995. Body fluids, circadian blood pressure and plasma renin during growth hormone administration: a placebo-controlled study with two growth hormone doses in healthy adults. Scand. J. Clin. Lab. Invest. 55(8):663-669 https://doi.org/10.3109/00365519509075396
  27. Van Soest, P. J., J. B. Robertson and B. A. Lewis. 1991. Methods for dietary fiber, neutral detergent fiber, and non-starch polysaccharides in relation to animal nutrition. J. Dairy Sci. 74:3583-3597 https://doi.org/10.3168/jds.S0022-0302(91)78551-2
  28. Armstrong, J. D. 1994. Heat stress interaction with shade and cooling. J. Dairy Sci. 77:2044-2050 https://doi.org/10.3168/jds.S0022-0302(94)77149-6
  29. Johannsson, G., Y. B. Sverrisdottir, L. Ellegard, P. A. Lundberg and H. Herlitz. 2002. GH increases extracellular volume by stimulating sodium reabsorption in the distal nephron and preventing pressure natriuresis. J. Clin. Endocrinol. Metab. 87: 1743-1749 https://doi.org/10.1210/jc.87.4.1743
  30. Chaiyabutr, N., S. Preuksakorn, S. Komolvanich and S. Chanpongsang. 2000. Comparative study on the regulation of body fluids and mammary circulation at different stages of lactation in crossbred Holstein cattle feeding on different types of roughage. J. Anim. Physiol. Anim. Nutr. 83:74-84 https://doi.org/10.1046/j.1439-0396.2000.00251.x
  31. Giordano, M. and R. A. Defronzo. 1995. Acute effect of human recombinant insulin-like growth factor I on renal function in humans. Nephron 71(1):10-15 https://doi.org/10.1159/000188667
  32. Prosser, C. G., S. R. Davis, V. C. Farr, L. G. Moore and P. D. Gluckman. 1994. Effects of close-arterial (external pudic) infusion of insulin-like growth factor-II on milk yield and mammary blood flow in lactating goats. J. Endocrinol. 142: 93-99 https://doi.org/10.1677/joe.0.1420093
  33. Smith, H. W. 1962. Principle of renal physiology, Oxford University Press: New York. 196-217
  34. Moller, J., N. Moller, E. Frandsen, T. Wolthers, J. O. Jorgensen and J. S. Christiansen. 1997. Blockade of the renninangiotensin-aldosterone system prevents growth hormone induced fluid retention in humans. Am. J. Physiol. 272:E803-E808
  35. Guler, H. P., C. Schmid, J. Zapf and E. R. Froesch. 1989. Effects of recombinant insulin-like growth factor I on insulin secretion and renal function in normal human subjects. Proc. Natl. Acad. Sci. USA. 86:2868-2872 https://doi.org/10.1073/pnas.86.8.2868
  36. Kirchgessner, M., W. Windisch, W. Schwab and H. L. Muller. 1991. Energy metabolism of lactating dairy cows treated with prolonged-release bovine somatotropin or energy deficiency. J. Dairy Sci. 74:35-43
  37. Tyrrell, H. F., A. C. G. Brown, P. J. Reynolds, G. L. Haaland, D. E. Bauman, C. J. Peel and W. D. Teinhoar. 1988. Effect of bovine somatotropin on metabolism of lactating cows energy and nitrogen utilization as determind by respiration calorimem. J. Nutr. 118:1024
  38. Ho, K. Y. and A. J. Weissberger. 1990. The antinatriuretic action of biosynthetic human growth hormone in man involves activation of the renin-angiotensin system. Metabolism 39(2): 133-137 https://doi.org/10.1016/0026-0495(90)90065-K
  39. Chaiyabutr, N., C. Buranakarl and P. Loypetjra. 1992. Renal regulation of urea excretion during urea infusion in acute heat exposed buffaloes. Asian- Aust. J. Anim. Sci. 5(1):81-90
  40. Fuquay, J. W. 1981. Heat stress as it affects animal production. J. Anim. Sci. 52:164-174
  41. Johnson, H. D., R. Li, W. Wu, K. J. Spencer-Johnson, B. A. Beckcr, R. J. Collier and C. A. Baile. 1991. Effects of somatotropin on milk yield and physiological responses during summer farm and hot laboratory conditions. J. Dairy Sci. 74:1250-1262 https://doi.org/10.3168/jds.S0022-0302(91)78281-7
  42. Chaiyabutr, N., S. Chanpongsang and S. Suadsong. 2008. Effects of evaporative cooling on the regulation of body water and milk production in crossbred Holstein cattle in a tropical environment. Int. J. Biometeorol. 52:575-585 https://doi.org/10.1007/s00484-008-0151-x
  43. Hahn, G. L., T. L. Mader, J. B. Gaughan, Q. Hu and J. A. Nienaber. 1999. Heat waves and their impacts on feedlot cattle. In: Proceeding, 15th International Society Biometerology congress September, Sydney, Australia, 353-357
  44. Chaiyabutr, N., S. Komolvanich, S. Sawangkun, S. Preuksakorn and S. Chanpongsang. 1997. The regulation of body fluids and mammary circulation during late pregnancy and early lactation of crossbred Holstein cattle feeding on different types of roughage. J. Anim. Physiol. Anim. Nutr. 77:167-179
  45. Elvinger, F., R. P. Natzke and P. J. Hansen. 1992. Interactions of heat stnss and bovine somatotropin affecting physiology and immunology of lactating cows. J. Dairy Sci. 75:449-462 https://doi.org/10.3168/jds.S0022-0302(92)77781-9

Cited by

  1. Regulation of fluid flow through the mammary gland of dairy cows and its effect on milk production: a systematic review pp.00225142, 2017, https://doi.org/10.1002/jsfa.8605

Acknowledgement

Supported by : Thailand Research Fund