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Effect of Acanthopanax extract on the DNA and erythrocyte damage induced by herbicides

제초제로 인한 DNA와 적혈구 손상에 미치는 오가피 추출물의 효과

  • Seo, Yoo-Na (Department of Medical Biotechnology, Soonchunhyang University) ;
  • Kim, Jum-Ji (Department of Medical Biotechnology, Soonchunhyang University) ;
  • Sung, Kwang-Soo (Sushin Ogapy Co., Ltd) ;
  • Lee, Mi-Young (Department of Medical Biotechnology, Soonchunhyang University)
  • 서유나 (순천향대학교 의료생명공학과) ;
  • 김점지 (순천향대학교 의료생명공학과) ;
  • 성광수 ((주) 수신오가피) ;
  • 이미영 (순천향대학교 의료생명공학과)
  • Received : 2001.11.05
  • Accepted : 2010.12.17
  • Published : 2010.12.31

Abstract

In order to investigate whether the ethanol extract of Acanthopanax sp. might inhibit herbicide-induced DNA damage and erythrocyte damage, the suppression of the oxidative DNA damage of lymphocyte and erythrocyte damage in the presence of the extract were evaluated by comet assay and hemolysis assay, respectively. Phenoxy herbicides, named 2,4-D (2,4-dichlorophenoxyacetic acid) and 2,4,5-T (2,4,5-trichlorophenoxyacetic acid) and bipyridyl herbicide paraquat induced oxidative DNA damages of lymphocytes. However, the oxidative DNA damage by 2,4-D, 2,4,5-T or paraquat was inhibited in vitro upon treating Acanthopanax extract. Moreover, the erythrocyte damage was also suppressed in vitro by Acanthopanax extract treatment.

Keywords

Paraquat;2,4-D;2,4,5-T;Comet assay;Hemolysis;Acanthopanax

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